In cultured human mural GL cells, ganirelix did not significantly change basal cAMP accumulation versus controls.
In plain wordsIn cells, ganirelix did not significantly change basal cAMP accumulation in human mural GL cells versus controls.
- Peptide
- Ganirelix
- Outcome
- No significant changeBasal cAMP in mural GL cells
- Study
humann: not reported in source
Cultured human mural granulosa-lutein and cumulus cells- Comparator
- Controls without ganirelix
- Outcome group
- Receptor activity and mechanism · Reproductive and sexual health
- Studied dose
- 1 nM · 48 hoursAs given in this study (human).
Source sentences
On the other hand, treatments with 1 nM GnRH antagonist ganirelix and 1 nM GnRH agonist triptorelin did not exert any significant changes on the basal and hCG-stimulated cAMP accumulation of mural GL cells and cumulus cells as compared with controls.
4 context sentences(design, population, supporting numbers)
In vitro cell culture study.
Mural GL and cumulus cells were obtained from 15 patients on whom controlled ovarian hyperstimulation was being performed for intracytoplasmic sperm injection treatment.
Mural GL and cumulus cells were cultured for 48 hours with and without 1 nM ganirelix or triptorelin.
For the last 6 hours, the cells were either exposed to 1-5 IU hCG or left unstimulated.