Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study.

Janssens RM, Lambalk CB, Vermeiden JP, Schats R, Bernards JM, Rekers-Mombarg LT, Schoemaker J

Human reproduction (Oxford, England)1 Nov 2000Cited by 60 (Europe PMC)

PMID11056128DOI10.1093/humrep/15.11.2333PepBankPUB-11056128

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, no triptorelin-treated patient had a premature LH surge, compared with 23% receiving placebo.
In plain wordsIn women undergoing IVF, premature LH surges occurred in no triptorelin-treated patients versus 23% receiving placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePremature LH surge
Study
n = 240
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
15, 50 or 100 microg dailyAs given in this study (human).
Measurements
Premature LH surge
23%
placebo
Source sentences
Summary
A premature LH surge occurred in 23% of placebo-treated patients, but in none of the triptorelin acetate-treated patients.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612801
02HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, the triptorelin group receiving 50 microg had significantly more oocytes, with the comparator unspecified.
In plain wordsIn women undergoing IVF, the 50 microg triptorelin group had more oocytes. The abstract does not specify the comparator.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOocyte number at intermediate dose
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 microg dailyAs given in this study (human).
Source sentences
Summary
There were significantly more oocytes and embryos in the 50 and 100 microg triptorelin groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612802
03HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, the triptorelin group receiving 100 microg had significantly more oocytes, with the comparator unspecified.
In plain wordsIn women undergoing IVF, the 100 microg triptorelin group had more oocytes. The abstract does not specify the comparator.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOocyte number at high dose
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 microg dailyAs given in this study (human).
Source sentences
Summary
There were significantly more oocytes and embryos in the 50 and 100 microg triptorelin groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612803
04HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, the triptorelin group receiving 50 microg had significantly more embryos, with the comparator unspecified.
In plain wordsIn women undergoing IVF, the 50 microg triptorelin group had more embryos. The abstract does not specify the comparator.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseEmbryo number at intermediate dose
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 microg dailyAs given in this study (human).
Source sentences
Summary
There were significantly more oocytes and embryos in the 50 and 100 microg triptorelin groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612804
05HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, the 50 and 100 microg daily triptorelin groups had significantly more embryos; the abstract does not name the comparison group.
In plain wordsIn women having IVF, the groups on 50 and 100 microg of triptorelin daily had more embryos. The abstract does not name the comparison group.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseEmbryo number in the 50 and 100 microg groups
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 and 100 microg dailyAs given in this study (human).
Source sentences
Summary
There were significantly more oocytes and embryos in the 50 and 100 microg triptorelin groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612805
06HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, implantation rates showed no relationship with triptorelin dose.
In plain wordsIn women undergoing IVF, implantation rates did not vary with triptorelin dose.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeImplantation dose relationship
Study
n: not reported in source
Comparator
Other triptorelin doses
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
15, 50 or 100 microg dailyAs given in this study (human).
Source sentences
Summary
There was no dose relationship in rates of either implantation, pregnancy, ongoing pregnancy, live birth or baby take-home.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612806
07HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, pregnancy rates showed no relationship with triptorelin dose.
In plain wordsIn women undergoing IVF, pregnancy rates did not vary with triptorelin dose.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePregnancy dose relationship
Study
n: not reported in source
Comparator
Other triptorelin doses
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
15, 50 or 100 microg dailyAs given in this study (human).
Source sentences
Summary
There was no dose relationship in rates of either implantation, pregnancy, ongoing pregnancy, live birth or baby take-home.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612807
08HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, ongoing pregnancy rates showed no relationship with triptorelin dose.
In plain wordsIn women undergoing IVF, ongoing pregnancy rates did not vary with triptorelin dose.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOngoing pregnancy dose relationship
Study
n: not reported in source
Comparator
Other triptorelin doses
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
15, 50 or 100 microg dailyAs given in this study (human).
Source sentences
Summary
There was no dose relationship in rates of either implantation, pregnancy, ongoing pregnancy, live birth or baby take-home.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612808
09HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, live birth rates showed no relationship with triptorelin dose.
In plain wordsIn women undergoing IVF, live birth rates did not vary with triptorelin dose.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLive birth dose relationship
Study
n: not reported in source
Comparator
Other triptorelin doses
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
15, 50 or 100 microg dailyAs given in this study (human).
Source sentences
Summary
There was no dose relationship in rates of either implantation, pregnancy, ongoing pregnancy, live birth or baby take-home.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612809
10HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, baby take-home rates showed no relationship with triptorelin dose.
In plain wordsIn women undergoing IVF, rates of taking a baby home did not vary with triptorelin dose.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeBaby take-home dose relationship
Study
n: not reported in source
Comparator
Other triptorelin doses
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
15, 50 or 100 microg dailyAs given in this study (human).
Source sentences
Summary
There was no dose relationship in rates of either implantation, pregnancy, ongoing pregnancy, live birth or baby take-home.
3 context sentences(design, population, supporting numbers)
Summary · context
Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol.
Summary · context
A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily.
Summary · context
Ovarian stimulation was performed with two or three ampoules of FSH daily.
Report a problemFND-1105612810

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.