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Study · Non-randomized trial · n = 6 · 2000

7 results

Endocrine activities of alexamorelin (Ala-His-d-2-methyl-Trp-Ala-Trp-d-Phe-Lys-NH2), a synthetic GH secretagogue, in humans.

Broglio F, Benso A, Gottero C, Muccioli G, Deghenghi R, Ghigo E, Arvat E

European journal of endocrinology1 Sept 2000Cited by 6 (Europe PMC)

PMID11022186 (opens in a new tab)DOI10.1530/eje.0.1430419 (opens in a new tab)PepBankPUB-11022186
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six young adults, intravenous hexarelin (1.0 and 2.0 microgram/kg) induced a dose-dependent increase in GH levels.

    In plain wordsIn six young adults, hexarelin raised growth hormone levels, and the rise was larger with the higher dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.0 and 2.0 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    ALEX and HEX (1.0 and 2.0 microgram/kg i.v.) induced the same dose-dependent increase of GH and PRL levels.
    1 context sentence
    Summary · context
    In six young adults we studied the effects of 1.0 and 2.0 microgram/kg i.v. ALEX or HEX on GH, PRL, ACTH, cortisol and aldosterone levels and those of 20mg p.o. ( approximately 300 microgram/kg) on GH levels.
  2. 02HumanNon-randomized trialEfficacy outcome

    In six young adults, intravenous hexarelin induced a dose-dependent increase in prolactin levels.

    In plain wordsIn six young adults, hexarelin raised prolactin levels, and the rise was larger with the higher dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseProlactin response to hexarelin
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1.0 and 2.0 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    ALEX and HEX (1.0 and 2.0 microgram/kg i.v.) induced the same dose-dependent increase of GH and PRL levels.
    1 context sentence
    Summary · context
    In six young adults we studied the effects of 1.0 and 2.0 microgram/kg i.v. ALEX or HEX on GH, PRL, ACTH, cortisol and aldosterone levels and those of 20mg p.o. ( approximately 300 microgram/kg) on GH levels.
  3. 03HumanNon-randomized trialEfficacy outcome

    In six young adults, intravenous hexarelin induced a dose-dependent increase in ACTH levels.

    In plain wordsIn six young adults, hexarelin raised ACTH levels, and the rise was larger with the higher dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseACTH response to hexarelin
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    1.0 and 2.0 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Both ALEX and HEX induced a dose-dependent increase of ACTH and cortisol levels.
    1 context sentence
    Summary · context
    In six young adults we studied the effects of 1.0 and 2.0 microgram/kg i.v. ALEX or HEX on GH, PRL, ACTH, cortisol and aldosterone levels and those of 20mg p.o. ( approximately 300 microgram/kg) on GH levels.
  4. 04HumanNon-randomized trialEfficacy outcome

    In six young adults, intravenous hexarelin induced a dose-dependent increase in cortisol levels.

    In plain wordsIn six young adults, hexarelin raised cortisol levels, and the rise was larger with the higher dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseCortisol response to hexarelin
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    1.0 and 2.0 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Both ALEX and HEX induced a dose-dependent increase of ACTH and cortisol levels.
    1 context sentence
    Summary · context
    In six young adults we studied the effects of 1.0 and 2.0 microgram/kg i.v. ALEX or HEX on GH, PRL, ACTH, cortisol and aldosterone levels and those of 20mg p.o. ( approximately 300 microgram/kg) on GH levels.
  5. 05HumanNon-randomized trialEfficacy outcome

    In six young adults, aldosterone levels did not increase significantly after intravenous hexarelin.

    In plain wordsIn six young adults, hexarelin did not significantly raise aldosterone levels.

    Peptide
    Hexarelin
    Outcome
    No significant changeAldosterone response to hexarelin
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    1.0 and 2.0 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Aldosterone levels significantly increased after both i.v. ALEX doses, but not after HEX.
    1 context sentence
    Summary · context
    In six young adults we studied the effects of 1.0 and 2.0 microgram/kg i.v. ALEX or HEX on GH, PRL, ACTH, cortisol and aldosterone levels and those of 20mg p.o. ( approximately 300 microgram/kg) on GH levels.
  6. 06HumanNon-randomized trialEfficacy outcome

    In six young adults, the ACTH and cortisol responses to intravenous hexarelin were significantly lower than those to the highest dose of alexamorelin.

    In plain wordsIn six young adults, hexarelin raised ACTH and cortisol less than the highest dose of alexamorelin did.

    Peptide
    Hexarelin
    Outcome
    DecreaseACTH and cortisol responses to hexarelin versus alexamorelin
    Study

    n = 6

    Comparator
    Alexamorelin
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    1.0 and 2.0 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    The ACTH and cortisol responses to the highest ALEX dose were significantly higher than those after HEX.
    1 context sentence
    Summary · context
    In six young adults we studied the effects of 1.0 and 2.0 microgram/kg i.v. ALEX or HEX on GH, PRL, ACTH, cortisol and aldosterone levels and those of 20mg p.o. ( approximately 300 microgram/kg) on GH levels.
  7. 07HumanNon-randomized trialEfficacy outcome

    In six young adults, the GH response to 20mg oral hexarelin was lower than that to the same dose of alexamorelin, but the difference was not significant.

    In plain wordsIn six young adults, oral hexarelin raised growth hormone a little less than alexamorelin did, and the difference was not significant.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to oral hexarelin versus alexamorelin
    Study

    n = 6

    Comparator
    Alexamorelin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    20mg · oralAs given in this study (human).

    Source sentences

    Summary
    The GH response to 20mg p.o. ALEX was higher, though not significantly, than that to the same HEX dose.
    1 context sentence
    Summary · context
    In six young adults we studied the effects of 1.0 and 2.0 microgram/kg i.v. ALEX or HEX on GH, PRL, ACTH, cortisol and aldosterone levels and those of 20mg p.o. ( approximately 300 microgram/kg) on GH levels.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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