Glutathione in the prevention of cisplatin induced toxicities. A prospectively randomized pilot trial in patients with head and neck cancer and non small cell lung cancer.

Schmidinger M, Budinsky AC, Wenzel C, Piribauer M, Brix R, Kautzky M, Oder W, Locker GJ, Zielinski CC, Steger GG

Wiener klinische Wochenschrift1 Jul 2000Cited by 32 (Europe PMC)

PMID11008323PepBankPUB-11008323

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanRandomized controlled trialSafety outcome
In patients with head and neck or non-small cell lung cancer receiving cisplatin, hemoglobin was higher with glutathione than with intensive hydration.
In plain wordsIn people with head and neck or lung cancer on cisplatin, hemoglobin was higher with glutathione than with intensive hydration.
Peptide
Glutathione
Outcome
IncreaseHemoglobin
Study
n = 20
Comparator
Intensive hydration control
Outcome group
Adverse events · Whole body
Studied dose
5 g immediately before cisplatinAs given in this study (human).
Measurements
Hemoglobin
10.7 mg%
glutathione group
Hemoglobin
9.5 mg%
control group
P value
0.039
Hemoglobin: glutathione group versus control group
Source sentences
Summary
The intensity of hematologic toxicity was significantly less pronounced in patients treated with Glutathione than in the control group (hemoglobin: 10.7 vs 9.5 mg% respectively, p = 0.039;
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832301
02HumanRandomized controlled trialSafety outcome
In patients with head and neck or non-small cell lung cancer receiving cisplatin, white blood cell count was higher with glutathione than with intensive hydration.
In plain wordsIn people with head and neck or lung cancer on cisplatin, white blood cell count was higher with glutathione than with intensive hydration.
Peptide
Glutathione
Outcome
IncreaseWhite blood cell count
Study
n = 20
Comparator
Intensive hydration control
Outcome group
Adverse events · Whole body
Studied dose
5 g immediately before cisplatinAs given in this study (human).
Measurements
White blood cell count
3.3 x 103/microliter
glutathione group
White blood cell count
2.2 x 103/microliter
control group
P value
0.004
White blood cell count: glutathione group versus control group
Source sentences
Summary
The intensity of hematologic toxicity was significantly less pronounced in patients treated with Glutathione than in the control group (hemoglobin: 10.7 vs 9.5 mg% respectively, p = 0.039; white blood cell count 3.3 vs 2.2 x 103/microliter respectively, p = 0.004;
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832302
03HumanRandomized controlled trialSafety outcome
In patients with head and neck or non-small cell lung cancer receiving cisplatin, platelet count was higher with glutathione than with intensive hydration.
In plain wordsIn people with head and neck or lung cancer on cisplatin, platelet count was higher with glutathione than with intensive hydration.
Peptide
Glutathione
Outcome
IncreasePlatelet count
Study
n = 20
Comparator
Intensive hydration control
Outcome group
Adverse events · Whole body
Studied dose
5 g immediately before cisplatinAs given in this study (human).
Measurements
Platelet count
167 x 103/microliter
glutathione group
Platelet count
95 x 103/microliter
control group
P value
0.02
Platelet count: glutathione group versus control group
Source sentences
Summary
platelets 167 vs 95 x 103/microliter respectively, p = 0.02)
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832303
04HumanRandomized controlled trialSafety outcome
In patients with head and neck or non-small cell lung cancer receiving cisplatin, non-hematologic toxicity did not differ between glutathione and intensive hydration.
In plain wordsIn people with head and neck or lung cancer on cisplatin, other side effects did not differ between glutathione and intensive hydration.
Peptide
Glutathione
Outcome
No significant changeNon-hematologic toxicity
Study
n = 20
Comparator
Intensive hydration control
Outcome group
Adverse events · Whole body
Studied dose
5 g immediately before cisplatinAs given in this study (human).
Source sentences
Summary
whereas in terms of non-hematologic toxicity no difference was observed.
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832304
05HumanRandomized controlled trialEfficacy outcome
In patients with solid tumors receiving cisplatin, overall survival did not differ significantly between glutathione and intensive hydration.
In plain wordsIn patients with solid tumors receiving chemotherapy, survival did not differ significantly between glutathione and intensive hydration.
Peptide
Glutathione
Outcome
No significant changeOverall survival
Study
n = 20
Comparator
Intensive hydration control
Outcome group
Mortality · Cancer
Studied dose
5 gAs given in this study (human).
Measurements
Overall survival
13.5 months
glutathione group
Overall survival
10.5 months
control group
Source sentences
Summary
However, there was no statistical difference in terms of response and overall survival (13.5 months vs. 10.5 months) between the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832308
06HumanRandomized controlled trialEfficacy outcome
In patients with advanced non-small cell lung or head and neck cancer receiving cisplatin, objective remission occurred in 6 of 11 evaluable patients with glutathione and 4 of 8 with intensive hydration, with no significant difference in response.
In plain wordsIn patients with advanced lung or head and neck cancer receiving chemotherapy, response did not differ significantly between glutathione and intensive hydration.
Peptide
Glutathione
Outcome
No significant changeObjective remission
Study
n = 19
Comparator
Intensive hydration control
Outcome group
Cancer treatment response · Cancer
Studied dose
5 gAs given in this study (human).
Measurements
Objective remission cases
6 patients
glutathione group, of 11 evaluable patients
Evaluable patients for objective remission
11 patients
glutathione group
Objective remission rate
55%
glutathione group
Objective remission cases
4 patients
control group, of 8 evaluable patients
Evaluable patients for objective remission
8 patients
control group
Source sentences
Summary
Objective remission occurred in 6 out of 11 evaluable patients from the group receiving Glutathione (55%; complete remission: 9%; partial remission: 46%), and in 4 out of 8 evaluable patients from the control group (partial remission: 50%).
4 context sentences(design, population, supporting numbers)
Summary · context
However, there was no statistical difference in terms of response and overall survival (13.5 months vs. 10.5 months) between the two groups.
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832305
07HumanRandomized controlled trialEfficacy outcome
In patients with solid tumors receiving cisplatin, partial remission occurred in 46% with glutathione and 50% with intensive hydration, and the abstract reports no statistical difference in response.
In plain wordsIn patients with solid tumors receiving chemotherapy, partial remission was 46% with glutathione and 50% with intensive hydration, with no statistical difference in response.
Peptide
Glutathione
Outcome
No significant changePartial remission
Study
n = 19
Comparator
Intensive hydration control
Outcome group
Cancer treatment response · Cancer
Studied dose
5 gAs given in this study (human).
Measurements
Partial remission rate
46%
glutathione group
Partial remission rate
50%
control group
Source sentences
Summary
Objective remission occurred in 6 out of 11 evaluable patients from the group receiving Glutathione (55%; complete remission: 9%; partial remission: 46%)
Summary
Objective remission occurred in 6 out of 11 evaluable patients from the group receiving Glutathione (55%; complete remission: 9%; partial remission: 46%), and in 4 out of 8 evaluable patients from the control group (partial remission: 50%).
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832307
08HumanRandomized controlled trialEfficacy outcome
In patients with solid tumors receiving glutathione with chemotherapy, complete remission occurred in 9%.
In plain wordsIn patients with solid tumors receiving glutathione with chemotherapy, 9% had complete remission.
Peptide
Glutathione
Outcome
Not applicableComplete remission
Study
n = 11
Outcome group
Cancer treatment response · Cancer
Studied dose
5 gAs given in this study (human).
Measurements
Complete remission rate
9%
glutathione group
Source sentences
Summary
Objective remission occurred in 6 out of 11 evaluable patients from the group receiving Glutathione (55%; complete remission: 9%; partial remission: 46%)
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty patients suffering from advanced non small cell lung cancer (n = 6) or head- and neck cancer (n = 14) were enrolled in the study.
Summary · context
Patients randomized to application of Glutathione (n = 11) received 5 g of Glutathione immediately before application of cisplatin followed by 2000 ml of normal saline.
Summary · context
Patients in the control group (n = 9) received 2000 ml electrolyte infusion before and 2000 ml of normal saline with forced diuresis after cisplatin.
Report a problemFND-1100832306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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