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Study · Animal study (in vivo) · rat · 2000

5 results

Comparative analysis of different puberty inhibiting mechanisms of two GnRH agonists and the GnRH antagonist cetrorelix using a female rat model.

Roth C, Leonhardt S, Seidel C, Luft H, Wuttke W, Jarry H

Pediatric research1 Oct 2000Cited by 29 (Europe PMC)

PMID11004237 (opens in a new tab)DOI10.1203/00006450-200010000-00009 (opens in a new tab)PepBankPUB-11004237
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, triptorelin delayed vaginal opening compared with controls.

    In plain wordsIn rats, triptorelin delayed vaginal opening compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseTiming of vaginal opening
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix, triptorelin, and buserelin retarded the onset of puberty as determined by delayed vaginal opening, lower ovarian weights, and lower serum estradiol levels.
    1 context sentence
    Summary · context
    We conducted two multigroup experiments (12 and 10 d, respectively) treating prepubertal/peripubertal female rats with either the GnRH agonist triptorelin or buserelin and compared them with rats treated with the GnRH antagonist cetrorelix and controls to assess the effects on pubertal progress and serum hormones.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, triptorelin reduced ovarian weight compared with controls.

    In plain wordsIn rats, triptorelin reduced ovarian weight compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseOvarian weight
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix, triptorelin, and buserelin retarded the onset of puberty as determined by delayed vaginal opening, lower ovarian weights, and lower serum estradiol levels.
    1 context sentence
    Summary · context
    We conducted two multigroup experiments (12 and 10 d, respectively) treating prepubertal/peripubertal female rats with either the GnRH agonist triptorelin or buserelin and compared them with rats treated with the GnRH antagonist cetrorelix and controls to assess the effects on pubertal progress and serum hormones.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, triptorelin reduced serum estradiol compared with controls.

    In plain wordsIn rats, triptorelin reduced estradiol levels compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSerum estradiol
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix, triptorelin, and buserelin retarded the onset of puberty as determined by delayed vaginal opening, lower ovarian weights, and lower serum estradiol levels.
    1 context sentence
    Summary · context
    We conducted two multigroup experiments (12 and 10 d, respectively) treating prepubertal/peripubertal female rats with either the GnRH agonist triptorelin or buserelin and compared them with rats treated with the GnRH antagonist cetrorelix and controls to assess the effects on pubertal progress and serum hormones.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, triptorelin stimulated LH levels, whereas cetrorelix inhibited them.

    In plain wordsIn rats, triptorelin increased LH levels, whereas cetrorelix reduced them.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseLH levels
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, although LH and FSH levels were stimulated by both agonists, they were inhibited by cetrorelix.
    1 context sentence
    Summary · context
    We conducted two multigroup experiments (12 and 10 d, respectively) treating prepubertal/peripubertal female rats with either the GnRH agonist triptorelin or buserelin and compared them with rats treated with the GnRH antagonist cetrorelix and controls to assess the effects on pubertal progress and serum hormones.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, triptorelin stimulated FSH levels, whereas cetrorelix inhibited them.

    In plain wordsIn rats, triptorelin increased FSH levels, whereas cetrorelix reduced them.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseFSH levels
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, although LH and FSH levels were stimulated by both agonists, they were inhibited by cetrorelix.
    1 context sentence
    Summary · context
    We conducted two multigroup experiments (12 and 10 d, respectively) treating prepubertal/peripubertal female rats with either the GnRH agonist triptorelin or buserelin and compared them with rats treated with the GnRH antagonist cetrorelix and controls to assess the effects on pubertal progress and serum hormones.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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