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Study · Non-randomized trial · n = 23 · 2000

6 results

Alprazolam, a benzodiazepine, blunts but does not abolish the ACTH and cortisol response to hexarelin, a GHRP, in obese patients.

Grottoli S, Arvat E, Gauna C, Maccagno B, Ramunni J, Giordano R, Maccario M, Deghenghi R, Ghigo E

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity1 Jun 2000Cited by 3 (Europe PMC)

PMID10997633 (opens in a new tab)DOI10.1038/sj.ijo.0801302 (opens in a new tab)PepBankPUB-10997633
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In obese patients, the ACTH response to hexarelin was higher than in normal subjects, but the difference was not statistically significant.

    In plain wordsIn obese patients, the ACTH response to hexarelin was not significantly different from that in normal subjects.

    Peptide
    Hexarelin
    Outcome
    No significant changeACTH response to hexarelin, obese versus normal subjects
    Study

    n = 23

    Comparator
    Normal subjects
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2.0 microg/kgAs given in this study (human).

    Source sentences

    Summary
    The HEX-induced ACTH response in OB was higher than that in n.s., but this difference did not attain statistical significance.
    1 context sentence
    Summary · context
    In nine obese patients (obese OB), 9 F, age, (34.8 +/- 3.7 y, body mass index (BMI), 35.0 +/- 2.2 kg/m2; WHR, 0.9 +/- 0.02), 14 controls (normal subjects, NS), 14 F, 30.4 +/- 0.9 y, 20.0 +/- 0.4 kg/m2), we studied the ACTH, F and GH responses to hexarelin (HEX, 2.0 microg/kg), a peptidyl GHS, alone…
  2. 02HumanNon-randomized trialEfficacy outcome

    In obese patients, the GH response to hexarelin was lower than in normal subjects.

    In plain wordsIn obese patients, the growth hormone response to hexarelin was lower than in normal subjects.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin, obese versus normal subjects
    Study

    n = 23

    Comparator
    Normal subjects
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2.0 microg/kgAs given in this study (human).

    Source sentences

    Summary
    The GH response to HEX in OB was lower (P < 0.02) than that in n.s..
    1 context sentence
    Summary · context
    In nine obese patients (obese OB), 9 F, age, (34.8 +/- 3.7 y, body mass index (BMI), 35.0 +/- 2.2 kg/m2; WHR, 0.9 +/- 0.02), 14 controls (normal subjects, NS), 14 F, 30.4 +/- 0.9 y, 20.0 +/- 0.4 kg/m2), we studied the ACTH, F and GH responses to hexarelin (HEX, 2.0 microg/kg), a peptidyl GHS, alone…

Studies that did not test the peptide alone4

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 03HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In normal subjects, alprazolam abolished the hexarelin-induced ACTH response. Hexarelin served as the stimulus.

    In plain wordsIn normal adults, alprazolam removed the ACTH rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of alprazolam on the ACTH response to hexarelin, normal subjects
    Study

    n = 14

    Comparator
    Hexarelin alone
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    In n.s. the HEX-induced ACTH response was abolished by ALP (P < 0.03)
    1 context sentence
    Summary · context
    In nine obese patients (obese OB), 9 F, age, (34.8 +/- 3.7 y, body mass index (BMI), 35.0 +/- 2.2 kg/m2; WHR, 0.9 +/- 0.02), 14 controls (normal subjects, NS), 14 F, 30.4 +/- 0.9 y, 20.0 +/- 0.4 kg/m2), we studied the ACTH, F and GH responses to hexarelin (HEX, 2.0 microg/kg), a peptidyl GHS, alone…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 04HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In normal subjects, alprazolam blunted the GH response to hexarelin. Hexarelin served as the stimulus.

    In plain wordsIn normal adults, alprazolam reduced the growth hormone rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of alprazolam on the GH response to hexarelin, normal subjects
    Study

    n = 14

    Comparator
    Hexarelin alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    ALP blunted the GH response to HEX in n.s. (P < 0.03)
    1 context sentence
    Summary · context
    In nine obese patients (obese OB), 9 F, age, (34.8 +/- 3.7 y, body mass index (BMI), 35.0 +/- 2.2 kg/m2; WHR, 0.9 +/- 0.02), 14 controls (normal subjects, NS), 14 F, 30.4 +/- 0.9 y, 20.0 +/- 0.4 kg/m2), we studied the ACTH, F and GH responses to hexarelin (HEX, 2.0 microg/kg), a peptidyl GHS, alone…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 05HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In obese patients, alprazolam only blunted the hexarelin-induced ACTH response. Hexarelin served as the stimulus.

    In plain wordsIn obese patients, alprazolam reduced but did not remove the ACTH rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of alprazolam on the ACTH response to hexarelin, obese patients
    Study

    n = 9

    Comparator
    Hexarelin alone
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    which, however, only blunted that in OB (P < 0.02).
    1 context sentence
    Summary · context
    In nine obese patients (obese OB), 9 F, age, (34.8 +/- 3.7 y, body mass index (BMI), 35.0 +/- 2.2 kg/m2; WHR, 0.9 +/- 0.02), 14 controls (normal subjects, NS), 14 F, 30.4 +/- 0.9 y, 20.0 +/- 0.4 kg/m2), we studied the ACTH, F and GH responses to hexarelin (HEX, 2.0 microg/kg), a peptidyl GHS, alone…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  4. 06HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In obese patients, alprazolam did not modify the GH response to hexarelin. Hexarelin served as the stimulus.

    In plain wordsIn obese patients, alprazolam did not change the growth hormone rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of alprazolam on the GH response to hexarelin, obese patients
    Study

    n = 9

    Comparator
    Hexarelin alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    while it did not modify that in OB.
    1 context sentence
    Summary · context
    In nine obese patients (obese OB), 9 F, age, (34.8 +/- 3.7 y, body mass index (BMI), 35.0 +/- 2.2 kg/m2; WHR, 0.9 +/- 0.02), 14 controls (normal subjects, NS), 14 F, 30.4 +/- 0.9 y, 20.0 +/- 0.4 kg/m2), we studied the ACTH, F and GH responses to hexarelin (HEX, 2.0 microg/kg), a peptidyl GHS, alone…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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