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Study · Animal study (in vivo) · rat · 1998

3 results

Hexarelin exhibits protective activity against cardiac ischaemia in hearts from growth hormone-deficient rats.

Berti F, Müller E, De Gennaro Colonna V, Rossoni G

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society1 Apr 1998Cited by 14 (Europe PMC)

PMID10990152 (opens in a new tab)DOI10.1016/s1096-6374(98)80041-5 (opens in a new tab)PepBankPUB-10990152
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In growth hormone-deficient rats, chronic hexarelin had a protective effect against ischaemic and post-ischaemic ventricular dysfunction.

    In plain wordsIn rats with low growth hormone, long-term hexarelin protected the heart against damage from reduced blood flow.

    Peptide
    Hexarelin
    Outcome
    DecreaseIschaemic and post-ischaemic ventricular dysfunction
    Study

    ratn: not reported in source

    GH-deficient rats (GHRH antiserum)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · chronicAs given in this study (rat).

    Source sentences

    Summary
    The chronic administration of hexarelin to these GH-deficient rats had a pronounced protective effect against ischaemic and post-ischaemic ventricular dysfunction.
    1 context sentence
    Summary · context
    Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH deficiency.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In perfused hearts from growth hormone-deficient rats, hexarelin prevented hyper-responsiveness of the coronary vascular bed to angiotensin II.

    In plain wordsIn rats with low growth hormone, hexarelin prevented an exaggerated response of heart blood vessels to angiotensin II.

    Peptide
    Hexarelin
    Outcome
    DecreaseCoronary hyper-responsiveness to angiotensin II
    Study

    ratn: not reported in source

    GH-deficient rats (GHRH antiserum)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · chronicAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin prevented hyper-responsiveness of the coronary vascular bed to angiotensin II
    1 context sentence
    Summary · context
    Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH deficiency.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In perfused hearts from growth hormone-deficient rats, hexarelin prevented the reduction in generation of 6-keto-prostaglandin F1alpha.

    In plain wordsIn rats with low growth hormone, hexarelin prevented a drop in a marker of blood vessel function in the heart.

    Peptide
    Hexarelin
    Outcome
    Increase6-keto-prostaglandin F1alpha generation
    Study

    ratn: not reported in source

    GH-deficient rats (GHRH antiserum)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · chronicAs given in this study (rat).

    Source sentences

    Summary
    also prevented the reduction in generation of 6-keto-prostaglandin F1alpha in perfused hearts from GH-deficient rats.
    1 context sentence
    Summary · context
    Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH deficiency.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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