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Study · Animal study (in vivo) · rat · 2000

2 results

EP 60761 and EP 50885, two hexarelin analogues, induce penile erection in rats.

Melis MR, Succu S, Spano MS, Locatelli V, Torsello A, Muller EE, Deghenghi R, Argiolas A

European journal of pharmacology1 Sept 2000Cited by 16 (Europe PMC)

PMID10980272 (opens in a new tab)DOI10.1016/s0014-2999(00)00481-7 (opens in a new tab)PepBankPUB-10980272
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, hexarelin injected into the paraventricular nucleus did not increase spontaneous penile erections, unlike its analogues EP 60761 and EP 50885.

    In plain wordsIn male rats, hexarelin injected into a brain area did not increase erections, while two related peptides did.

    Peptide
    Hexarelin
    Outcome
    No significant changeSpontaneous penile erections after hexarelin
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    2-2000 ng · injection into the paraventricular nucleusAs given in this study (rat).

    Source sentences

    Summary
    Of these peptides, EP 60761 and EP 50885, but not hexarelin, EP 40904 or EP 40737, increased dose-dependently the number of spontaneous penile erections.
    1 context sentence
    Summary · context
    The effect of hexarelin and four related peptide analogues, EP 40904, EP 40737, EP 50885 and EP 60761, injected into the paraventricular nucleus of the hypothalamus of male rats in doses between 2 and 2000 ng on spontaneous penile erection was studied.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, an oxytocin receptor antagonist given i.c.v. prevented penile erection induced by the hexarelin analogues EP 60761 and EP 50885. Oxytocin itself was not given.

    In plain wordsIn male rats, blocking oxytocin receptors in the brain prevented erections caused by two hexarelin-related peptides.

    Peptide
    Oxytocin
    Outcome
    Not applicableBlock of analogue-induced penile erection by an oxytocin receptor antagonist
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    EP 60761- and EP 50885-induced penile erection was prevented by the oxytocin receptor antagonist [d(CH(2))(5)Tyr(Me)(2)-Orn(8)]vasotocin (0.1-1 microg)
    1 context sentence
    Summary · context
    The effect of hexarelin and four related peptide analogues, EP 40904, EP 40737, EP 50885 and EP 60761, injected into the paraventricular nucleus of the hypothalamus of male rats in doses between 2 and 2000 ng on spontaneous penile erection was studied.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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