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Study · Ex vivo tissue · chick · 2000

3 results

Studies of cytokines in nerve tissue cultures.

Chalisova NI, Khavinson VK

Neuroscience and behavioral physiology1 May 2000Cited by 2 (Europe PMC)

PMID10970020 (opens in a new tab)DOI10.1007/bf02471779 (opens in a new tab)PepBankPUB-10970020
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In chick embryo ganglion cultures, cortexin stimulated neurite growth at both tested concentrations.

    In plain wordsIn lab tests, cortexin stimulated nerve process growth in chick embryo ganglion cultures.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseDorsal root ganglion neurite growth
    Study

    chickn: not reported in source

    embryonic organotypic neural tissue cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 and 100 ng/ml · 3 daysAs given in this study (chick).

    Source sentences

    Summary
    Cortexin (20 and 100 ng/ml), epithalamin (20 and 200 ng/ml), polypeptides M and P (2 and 20 ng/ml) had neurite-stimulating actions, evident on day 3 of dorsal root ganglion culture.
    1 context sentence
    Summary · context
    The effects of cortexin, epithalamin, and synthetic peptides on the growth of processes in sensory neurons and on the development of fragments of cortical and subcortical brain structures were studied in organotypic cultures from 10-11-day chick embryos.
  2. 02LabEx vivo tissueActivity measurement

    In chick embryo cerebral cortex explants, cortexin stimulated development.

    In plain wordsIn lab tests, cortexin stimulated chick embryo cerebral cortex tissue development.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseCerebral cortex explant development
    Study

    chickn: not reported in source

    embryonic organotypic neural tissue cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 ng/mlAs given in this study (chick).

    Source sentences

    Summary
    Addition of cortexin (100 ng/ml) or polypeptide M (20 ng/ml) to the culture medium of cerebral cortex explants stimulated explant development.
    1 context sentence
    Summary · context
    The effects of cortexin, epithalamin, and synthetic peptides on the growth of processes in sensory neurons and on the development of fragments of cortical and subcortical brain structures were studied in organotypic cultures from 10-11-day chick embryos.
  3. 03LabEx vivo tissueActivity measurement

    In chick embryo subcortical explants, cortexin suppressed development.

    In plain wordsIn lab tests, cortexin suppressed chick embryo subcortical tissue development.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseSubcortical explant development
    Study

    chickn: not reported in source

    embryonic organotypic neural tissue cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 ng/mlAs given in this study (chick).

    Source sentences

    Summary
    Addition of cortexin at the same concentration to explants of subcortical formations suppressed their development.
    2 context sentences
    Summary · context
    Addition of cortexin (100 ng/ml) or polypeptide M (20 ng/ml) to the culture medium of cerebral cortex explants stimulated explant development.
    Summary · context
    The effects of cortexin, epithalamin, and synthetic peptides on the growth of processes in sensory neurons and on the development of fragments of cortical and subcortical brain structures were studied in organotypic cultures from 10-11-day chick embryos.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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