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Study · Non-randomized trial · n = 19 · 2000

5 results

Differences of hexarelin-induced prolactin and cortisol responses between prepubertal and early pubertal short children and lack of correlation with gonadotropin-releasing hormone-induced gonadotropin response.

Guzzaloni G, Grugni G, Morabito F

Journal of pediatric endocrinology & metabolism : JPEM1 Jul 2000

PMID10968479 (opens in a new tab)DOI10.1515/jpem.2000.13.7.907 (opens in a new tab)PepBankPUB-10968479
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In children with short stature, hexarelin induced a strong GH increase in both prepubertal and early pubertal groups.

    In plain wordsIn children with short stature, hexarelin caused a strong rise in growth hormone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin
    Study

    n = 19

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    HEX induced a strong GH and a slight PRL increase in prepubertal and early pubertal children
    1 context sentence
    Summary · context
    We evaluated GH, PRL and F responses to HEX (2 microg/kg i.v.) in 19 children with short stature, 12 prepubertal (Tanner stage I) and 7 early pubertal (stage II), and their correlation with those of FSH and LH to GnRH and with the serum levels of testosterone (T) or estradiol (E2).
  2. 02HumanNon-randomized trialEfficacy outcome

    In children with short stature, hexarelin induced a slight prolactin increase in both prepubertal and early pubertal groups.

    In plain wordsIn children with short stature, hexarelin caused a slight rise in prolactin.

    Peptide
    Hexarelin
    Outcome
    IncreaseProlactin response to hexarelin
    Study

    n = 19

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    HEX induced a strong GH and a slight PRL increase in prepubertal and early pubertal children
    1 context sentence
    Summary · context
    We evaluated GH, PRL and F responses to HEX (2 microg/kg i.v.) in 19 children with short stature, 12 prepubertal (Tanner stage I) and 7 early pubertal (stage II), and their correlation with those of FSH and LH to GnRH and with the serum levels of testosterone (T) or estradiol (E2).
  3. 03HumanNon-randomized trialEfficacy outcome

    In children with short stature, cortisol secretion was not affected by hexarelin in either the prepubertal or the early pubertal group.

    In plain wordsIn children with short stature, hexarelin did not change cortisol in either group.

    Peptide
    Hexarelin
    Outcome
    No significant changeCortisol response to hexarelin
    Study

    n = 19

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    while F secretion was not affected in either group
    1 context sentence
    Summary · context
    We evaluated GH, PRL and F responses to HEX (2 microg/kg i.v.) in 19 children with short stature, 12 prepubertal (Tanner stage I) and 7 early pubertal (stage II), and their correlation with those of FSH and LH to GnRH and with the serum levels of testosterone (T) or estradiol (E2).
  4. 04HumanNon-randomized trialEfficacy outcome

    In children with short stature, the extent of the GH and prolactin response to hexarelin did not differ between prepubertal and early pubertal children.

    In plain wordsIn children with short stature, the size of the hexarelin response was similar in prepubertal and early pubertal children.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH and PRL response, prepubertal versus early pubertal
    Study

    n = 19

    Comparator
    Prepubertal versus early pubertal children
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    with no differences in the extent of the response
    1 context sentence
    Summary · context
    We evaluated GH, PRL and F responses to HEX (2 microg/kg i.v.) in 19 children with short stature, 12 prepubertal (Tanner stage I) and 7 early pubertal (stage II), and their correlation with those of FSH and LH to GnRH and with the serum levels of testosterone (T) or estradiol (E2).
  5. 05HumanNon-randomized trialMechanism

    In children with short stature, the responses to hexarelin did not correlate with the gonadotropin responses to GnRH or with basal testosterone or estradiol.

    In plain wordsIn children with short stature, hexarelin responses were not linked to gonadotropin responses or to sex hormone levels.

    Peptide
    Hexarelin
    Outcome
    No significant changeCorrelation of hexarelin responses with gonadotropin response and sex steroids
    Study

    n = 19

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    these responses did not correlate with those of the gonadotropins to GnRH nor with basal T or E2.
    1 context sentence
    Summary · context
    We evaluated GH, PRL and F responses to HEX (2 microg/kg i.v.) in 19 children with short stature, 12 prepubertal (Tanner stage I) and 7 early pubertal (stage II), and their correlation with those of FSH and LH to GnRH and with the serum levels of testosterone (T) or estradiol (E2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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