Usefulness of the desmopressin test in the postoperative evaluation of patients with Cushing's disease.

Colombo P, Dall'Asta C, Barbetta L, Re T, Passini E, Faglia G, Ambrosi B

European journal of endocrinology1 Aug 2000Cited by 35 (Europe PMC)

PMID10913942DOI10.1530/eje.0.1430227PepBankPUB-10913942

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Desmopressin.

01HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In active Cushing's disease, desmopressin increased ACTH from 15.3+/-2.7 to 40.9+/-7.3 pmol/l (P<0.001).
In plain wordsIn patients with active Cushing's disease, ACTH increased after the desmopressin test.
Peptide
Desmopressin
Outcome
IncreaseACTH response in active disease
Study
n = 24
Outcome group
Adrenal hormone response · Endocrine and hormones
Measurements
Plasma ACTH baseline
15.3 pmol/l
active Cushing's disease, before desmopressin 10 microg i.v. (+/-2.7)
Plasma ACTH peak
40.9 pmol/l
active Cushing's disease, after desmopressin (+/-7.3)
Source sentences
Summary
In 24 patients with active Cushing's disease a significant ACTH/cortisol response (P<0.001) was induced by either desmopressin (ACTH from a baseline of 15.3+/-2.7 pmol/l to a peak of 40.9+/-7.3 pmol/l; cortisol from 673+/-59 nmol/l to 1171+/-90 nmol/l)
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394201
02HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In active Cushing's disease, desmopressin increased cortisol from 673+/-59 to 1171+/-90 nmol/l (P<0.001).
In plain wordsIn patients with active Cushing's disease, cortisol increased after the desmopressin test.
Peptide
Desmopressin
Outcome
IncreaseCortisol response in active disease
Study
n = 24
Outcome group
Adrenal hormone response · Endocrine and hormones
Measurements
Serum cortisol baseline
673 nmol/l
active Cushing's disease, before desmopressin (+/-59)
Serum cortisol peak
1171 nmol/l
active Cushing's disease, after desmopressin (+/-90)
Source sentences
Summary
In 24 patients with active Cushing's disease a significant ACTH/cortisol response (P<0.001) was induced by either desmopressin (ACTH from a baseline of 15.3+/-2.7 pmol/l to a peak of 40.9+/-7.3 pmol/l; cortisol from 673+/-59 nmol/l to 1171+/-90 nmol/l)
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394202
03HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
All patients with active Cushing's disease had a positive cortisol response to desmopressin.
In plain wordsAll patients with active Cushing's disease had a positive cortisol response to the desmopressin test.
Peptide
Desmopressin
Outcome
IncreasePositive cortisol response
Study
n = 24
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
In all patients a positive cortisol response to desmopressin was found.
2 context sentences(design, population, supporting numbers)
Summary · context
In 24 patients with active Cushing's disease a significant ACTH/cortisol response (P<0.001) was induced by either desmopressin (ACTH from a baseline of 15.3+/-2.7 pmol/l to a peak of 40.9+/-7.3 pmol/l; cortisol from 673+/-59 nmol/l to 1171+/-90 nmol/l) or CRH (ACTH from a basal of 14.
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394203
04HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In cured Cushing's disease patients followed for 1-36 months after surgery, desmopressin never induced ACTH responsiveness.
In plain wordsIn cured Cushing's disease patients, the postoperative desmopressin test did not induce ACTH responsiveness.
Peptide
Desmopressin
Outcome
No significant changePostoperative ACTH responsiveness in cured patients
Study
n = 14
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
After pituitary adenomectomy the 14 'cured' patients were followed up for 1-36 months; desmopressin administration never induced ACTH or cortisol responsiveness in any patient.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394204
05HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In cured Cushing's disease patients followed for 1-36 months after surgery, desmopressin never induced cortisol responsiveness.
In plain wordsIn cured Cushing's disease patients, the postoperative desmopressin test did not induce cortisol responsiveness.
Peptide
Desmopressin
Outcome
No significant changePostoperative cortisol responsiveness in cured patients
Study
n = 14
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
After pituitary adenomectomy the 14 'cured' patients were followed up for 1-36 months; desmopressin administration never induced ACTH or cortisol responsiveness in any patient.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394205
06HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In six long-term cured Cushing's disease patients, desmopressin induced no ACTH concentration changes.
In plain wordsIn six long-term cured Cushing's disease patients, the desmopressin test did not change ACTH concentrations.
Peptide
Desmopressin
Outcome
No significant changeACTH in long-term cured patients
Study
n = 6
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
Of 10 patients studied only after long-term follow-up, six were cured and a normal response to CRH was present, whereas no changes in ACTH/cortisol concentrations were induced by desmopressin.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394209
07HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In six long-term cured Cushing's disease patients, desmopressin induced no cortisol concentration changes.
In plain wordsIn six long-term cured Cushing's disease patients, the desmopressin test did not change cortisol concentrations.
Peptide
Desmopressin
Outcome
No significant changeCortisol in long-term cured patients
Study
n = 6
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
Of 10 patients studied only after long-term follow-up, six were cured and a normal response to CRH was present, whereas no changes in ACTH/cortisol concentrations were induced by desmopressin.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394210
08HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In five Cushing's disease patients whose cortisol only normalized after surgery, desmopressin responsiveness persisted.
In plain wordsIn five Cushing's disease patients whose cortisol normalized after surgery, responsiveness to the desmopressin test persisted.
Peptide
Desmopressin
Outcome
Not applicablePersistent response after cortisol normalization
Study
n = 5
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
Five patients, in whom the cortisol concentration only normalized after surgery, showed a persistent responsiveness to desmopressin, and two of them relapsed 12 and 24 months later.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394206
09HumanNot a test of Desmopressin aloneNon-randomized trialOther
Among five postoperative Cushing's disease patients with persistent desmopressin responsiveness, two relapsed at 12 and 24 months.
In plain wordsAmong five postoperative patients with persistent desmopressin test responses, two had Cushing's disease relapse at 12 and 24 months.
Peptide
Desmopressin
Outcome
Not applicableRelapse after persistent test response
Study
n = 5
Outcome group
Adrenal hormone response · Endocrine and hormones
Measurements
Patients who relapsed
2 patients
of 5 with persistent desmopressin responsiveness
Time to relapse
12 months
first relapsed patient
Time to relapse
24 months
second relapsed patient
Source sentences
Summary
Five patients, in whom the cortisol concentration only normalized after surgery, showed a persistent responsiveness to desmopressin, and two of them relapsed 12 and 24 months later.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394207
10HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In five uncured Cushing's disease patients, hormonal responsiveness to desmopressin was similar before and after surgery.
In plain wordsIn five uncured Cushing's disease patients, hormonal responsiveness to desmopressin was similar before and after surgery.
Peptide
Desmopressin
Outcome
Not applicableHormonal responsiveness in uncured patients
Study
n = 5
Comparator
Before surgery
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
In five patients who were not cured, the hormonal responsiveness to either CRH or desmopressin was similar before and after operation.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394208
11HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In four unsuccessfully operated patients with Cushing's disease who had pituitary irradiation, hormonal responses to desmopressin and to CRH were different and equivocal.
In plain wordsIn four Cushing's disease patients after unsuccessful surgery and irradiation, responses to the desmopressin test and to the CRH test were different and equivocal.
Peptide
Desmopressin
Outcome
MixedHormonal responses after unsuccessful surgery and irradiation
Study
n = 4
Outcome group
Adrenal hormone response · Endocrine and hormones
Source sentences
Summary
The other four unsuccessfully operated patients underwent pituitary irradiation and showed different and equivocal hormonal responses to desmopressin and to CRH.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1091394211

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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