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Study · Animal study (in vivo) · rat · 2000

7 results

Hexarelin, a growth hormone secretagogue, protects the isolated rat heart from ventricular dysfunction produced by exposure to calcium-free medium.

Rossoni G, Locatelli V, Gennaro Colonna Vd, Müller EE, Berti F

Pharmacological research1 Aug 2000Cited by 7 (Europe PMC)

PMID10887041 (opens in a new tab)DOI10.1006/phrs.2000.0665 (opens in a new tab)PepBankPUB-10887041
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In isolated rat hearts, hexarelin given for 3 and 7 days time-dependently reduced the sudden rise in resting tension on calcium repletion.

    In plain wordsIn rats, hexarelin given for several days reduced the heart tension rise caused by calcium depletion and return.

    Peptide
    Hexarelin
    Outcome
    DecreaseResting tension on calcium repletion
    Study

    ratn: not reported in source

    isolated perfused heart, calcium paradox
    Comparator
    Controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg · subcutaneous · 3 and 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin, (80 microg kg(-1)s.c.) administered to normal male young rats for 3 and 7-day, time-dependently antagonized the sudden increase in resting tension of the isolated perfused hearts upon Ca(2+)-repletion.
    1 context sentence
    Summary · context
    The effect of hexarelin, a potent synthetic growth hormone (GH)-secretagogue, and of human GH were studied on the mechanical and metabolic changes elicited by the calcium-paradox phenomenon in isolated rat hearts submitted to 5 min Ca(2+)-depletion followed by reperfusion with reintegrated Ca(2+)medium.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In isolated rat hearts after 7 days of hexarelin, peak ventricular contraction was 30 mmHg versus 76 mmHg in controls.

    In plain wordsIn rats, hearts from animals given hexarelin for 7 days showed a smaller contraction surge than control hearts.

    Peptide
    Hexarelin
    Outcome
    DecreasePeak ventricular contraction after 7-day treatment
    Study

    ratn: not reported in source

    isolated perfused heart, calcium paradox
    Comparator
    Controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Measurements

    Peak ventricular contraction
    30 mmHg
    hexarelin 7 days
    Peak ventricular contraction
    76 mmHg
    controls

    Source sentences

    Summary
    ventricular contraction peaked at 30 +/- 2 mmHg (controls, 76 +/- 7 mmHg)
    1 context sentence
    Summary · context
    The effect of hexarelin, a potent synthetic growth hormone (GH)-secretagogue, and of human GH were studied on the mechanical and metabolic changes elicited by the calcium-paradox phenomenon in isolated rat hearts submitted to 5 min Ca(2+)-depletion followed by reperfusion with reintegrated Ca(2+)medium.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In isolated rat hearts after 7 days of hexarelin, recovery of left ventricular developed pressure was two times higher than in controls (P<0.001).

    In plain wordsIn rats, hearts from animals given hexarelin for 7 days recovered pressure about twice as well as control hearts.

    Peptide
    Hexarelin
    Outcome
    IncreaseRecovery of left ventricular developed pressure
    Study

    ratn: not reported in source

    isolated perfused heart, calcium paradox
    Comparator
    Controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    the recovery of left ventricular developed pressure (LVDP) was two times higher (P<0.001)
    1 context sentence
    Summary · context
    The effect of hexarelin, a potent synthetic growth hormone (GH)-secretagogue, and of human GH were studied on the mechanical and metabolic changes elicited by the calcium-paradox phenomenon in isolated rat hearts submitted to 5 min Ca(2+)-depletion followed by reperfusion with reintegrated Ca(2+)medium.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In isolated rat hearts, hexarelin reduced creatine kinase release into the effluent by 40% versus controls (P<0.001).

    In plain wordsIn rats, hexarelin reduced the release of a heart-damage marker, creatine kinase, by 40% compared with controls.

    Peptide
    Hexarelin
    Outcome
    DecreaseCreatine kinase release during calcium repletion
    Study

    ratn: not reported in source

    isolated perfused heart, calcium paradox
    Comparator
    Controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg · subcutaneous · 3 and 7 daysAs given in this study (rat).

    Measurements

    Creatine kinase release reduction
    40%
    hexarelin versus controls

    Source sentences

    Summary
    Moreover, the release of creatine kinase into the heart effluent during Ca(2+)-repletion was reduced by 40% (P<0.001) as compared to controls.
    1 context sentence
    Summary · context
    The effect of hexarelin, a potent synthetic growth hormone (GH)-secretagogue, and of human GH were studied on the mechanical and metabolic changes elicited by the calcium-paradox phenomenon in isolated rat hearts submitted to 5 min Ca(2+)-depletion followed by reperfusion with reintegrated Ca(2+)medium.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats given hexarelin, plasma and heart IGF-1 concentrations were similar to those in control rats.

    In plain wordsIn rats, hexarelin did not change IGF-1 levels in blood or heart compared with controls.

    Peptide
    Hexarelin
    Outcome
    No significant changePlasma and heart IGF-1 concentrations
    Study

    ratn: not reported in source

    isolated perfused heart, calcium paradox
    Comparator
    Controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    80 microg/kg · subcutaneous · 3 and 7 daysAs given in this study (rat).

    Source sentences

    Summary
    plasma and heart concentrations of IGF-1 were similar to those measured in control rats.
    1 context sentence
    Summary · context
    The effect of hexarelin, a potent synthetic growth hormone (GH)-secretagogue, and of human GH were studied on the mechanical and metabolic changes elicited by the calcium-paradox phenomenon in isolated rat hearts submitted to 5 min Ca(2+)-depletion followed by reperfusion with reintegrated Ca(2+)medium.
  6. 06LabEx vivo tissueEfficacy outcome

    In isolated rat hearts, perfusion with hexarelin for 60 min did not modify heart contractility.

    In plain wordsIn rats, hexarelin added directly to the perfused heart for 60 minutes did not change heart contraction.

    Peptide
    Hexarelin
    Outcome
    No significant changeHeart contractility with hexarelin perfusion
    Study

    ratn: not reported in source

    isolated perfused heart, calcium paradox
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    8 microg/ml · perfusion · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin (8 microg ml(-1)) perfused for 60 min through the hearts in recirculating conditions did not modify heart contractility
    1 context sentence
    Summary · context
    The effect of hexarelin, a potent synthetic growth hormone (GH)-secretagogue, and of human GH were studied on the mechanical and metabolic changes elicited by the calcium-paradox phenomenon in isolated rat hearts submitted to 5 min Ca(2+)-depletion followed by reperfusion with reintegrated Ca(2+)medium.
  7. 07LabEx vivo tissueEfficacy outcome

    In isolated rat hearts, hexarelin perfusion for 60 min failed to prevent ventricular hypercontractility on calcium readmission.

    In plain wordsIn rats, hexarelin added directly to the perfused heart did not stop the contraction surge after calcium returned.

    Peptide
    Hexarelin
    Outcome
    No significant changeVentricular hypercontractility on calcium readmission with hexarelin perfusion
    Study

    ratn: not reported in source

    isolated perfused heart, calcium paradox
    Comparator
    Controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    8 microg/ml · perfusion · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin (8 microg ml(-1)) perfused for 60 min through the hearts in recirculating conditions did not modify heart contractility and failed to prevent ventricular hypercontractility developed on Ca(2+)-readmission.
    1 context sentence
    Summary · context
    The effect of hexarelin, a potent synthetic growth hormone (GH)-secretagogue, and of human GH were studied on the mechanical and metabolic changes elicited by the calcium-paradox phenomenon in isolated rat hearts submitted to 5 min Ca(2+)-depletion followed by reperfusion with reintegrated Ca(2+)medium.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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