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Study · Animal study (in vivo) · 2000

5 results

[The prevention of suppurative-septic complications in severe burns by using immunotropic drug preparations in an experiment].

Pylaeva SI, Gordinskaia NA, Vazina IR, Sidorkin VG, Bushuev IuI

Zhurnal mikrobiologii, epidemiologii i immunobiologii1 Jan 2000

PMID10876901 (opens in a new tab)PepBankPUB-10876901
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In burned animals, a single injection of the course dose of thymalin prevented generalization of infection.

    In plain wordsIn burned animals, one injection of the course dose of thymalin prevented infection from spreading throughout the body.

    Peptide
    Thymalin
    Outcome
    DecreaseGeneralization of infection
    Study

    n: not reported in source

    Thermal burns with Pseudomonas infection
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Course dose · InjectionAs given in this study.

    Source sentences

    Summary
    The use of the course dose of any of these substances, introduced in a single injection, prevented the generalization of infection.
    2 context sentences
    Summary · context
    The prophylactic and therapeutic action of immunotropic preparations in different doses on the development of Pseudomonas infection of experimental animals with thermal burns was evaluated.
    Summary · context
    Natural marrow and thymic regulatory peptides (myelopid, tactivin and thymalin), as well as the synthetic immunopreparation polyoxydonium, were used for immunocorrection.

Studies that did not test the peptide alone4

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

  1. 02AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In burned animals, the tested immunomodulators, including thymalin, at recommended doses did not affect the infectious process.

    In plain wordsIn burned animals, the tested immunomodulators, including thymalin, at recommended doses did not change the infection course.

    Peptide
    Thymalin
    Outcome
    No significant changeInfectious process at recommended doses
    Study

    n: not reported in source

    Thermal burns with Pseudomonas infection
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    The study revealed that the injection of these immunomodulators in doses recommended by instructions for use did not affect the course of the infectious process, antibody production by immunocompetent cells and the death rate of experimental animals.
    2 context sentences
    Summary · context
    The prophylactic and therapeutic action of immunotropic preparations in different doses on the development of Pseudomonas infection of experimental animals with thermal burns was evaluated.
    Summary · context
    Natural marrow and thymic regulatory peptides (myelopid, tactivin and thymalin), as well as the synthetic immunopreparation polyoxydonium, were used for immunocorrection.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  2. 03AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In burned animals, the tested immunomodulators, including thymalin, at recommended doses did not affect antibody production.

    In plain wordsIn burned animals, the tested immunomodulators, including thymalin, at recommended doses did not change antibody production.

    Peptide
    Thymalin
    Outcome
    No significant changeAntibody production at recommended doses
    Study

    n: not reported in source

    Thermal burns with Pseudomonas infection
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The study revealed that the injection of these immunomodulators in doses recommended by instructions for use did not affect the course of the infectious process, antibody production by immunocompetent cells and the death rate of experimental animals.
    2 context sentences
    Summary · context
    The prophylactic and therapeutic action of immunotropic preparations in different doses on the development of Pseudomonas infection of experimental animals with thermal burns was evaluated.
    Summary · context
    Natural marrow and thymic regulatory peptides (myelopid, tactivin and thymalin), as well as the synthetic immunopreparation polyoxydonium, were used for immunocorrection.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  3. 04AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In burned animals, the tested immunomodulators, including thymalin, at recommended doses did not affect death rate.

    In plain wordsIn burned animals, the tested immunomodulators, including thymalin, at recommended doses did not change death rates.

    Peptide
    Thymalin
    Outcome
    No significant changeDeath rate at recommended doses
    Study

    n: not reported in source

    Thermal burns with Pseudomonas infection
    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    The study revealed that the injection of these immunomodulators in doses recommended by instructions for use did not affect the course of the infectious process, antibody production by immunocompetent cells and the death rate of experimental animals.
    2 context sentences
    Summary · context
    The prophylactic and therapeutic action of immunotropic preparations in different doses on the development of Pseudomonas infection of experimental animals with thermal burns was evaluated.
    Summary · context
    Natural marrow and thymic regulatory peptides (myelopid, tactivin and thymalin), as well as the synthetic immunopreparation polyoxydonium, were used for immunocorrection.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  4. 05AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In burned animals, the tested immunomodulators, including thymalin, reduced death rate from 80.3% to 47.2% with single course-dose injections.

    In plain wordsIn burned animals, the tested immunomodulators, including thymalin, reduced death rate from 80.3% to 47.2% with single course-dose injections.

    Peptide
    Thymalin
    Outcome
    DecreaseDeath rate with single course-dose injection
    Study

    n: not reported in source

    Thermal burns with Pseudomonas infection
    Outcome group
    Mortality · Whole body

    Measurements

    Death rate
    80.3%
    Initial rate
    Death rate
    47.2%
    Single course-dose injection

    Source sentences

    Summary
    The death rate of experimental animals dropped from 80.3% to 47.2%.
    3 context sentences
    Summary · context
    The use of the course dose of any of these substances, introduced in a single injection, prevented the generalization of infection.
    Summary · context
    The prophylactic and therapeutic action of immunotropic preparations in different doses on the development of Pseudomonas infection of experimental animals with thermal burns was evaluated.
    Summary · context
    Natural marrow and thymic regulatory peptides (myelopid, tactivin and thymalin), as well as the synthetic immunopreparation polyoxydonium, were used for immunocorrection.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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