Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.

Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ, Edwards CM, Heath MM, Stanley SA, Seal LJ, Bhatti JR, Smith DM, Ghatei MA, Bloom SR

Diabetes1 Feb 2000Cited by 166 (Europe PMC)

PMID10868932DOI10.2337/diabetes.49.2.177PepBankPUB-10868932

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In fasted rats, NDP-MSH injected into the paraventricular nucleus decreased food intake by 52% at 1 h postinjection.
In plain wordsIn rats, NDP-MSH given into one brain area cut food intake by about half.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseFood intake after NDP-MSH in PVN
Study
ratn: not reported in source
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
0.1 nmol · cannula injection into hypothalamic nucleiAs given in this study (rat).
Measurements
Food intake reduction
52%
PVN, 1 h
Source sentences
Summary
NDP-MSH decreased food intake in the PVN by 52 +/- 6% (P < 0.005), in the DMN by 44 +/- 6% (P < 0.0001), and in the MPO by 55 +/- 6% (P < 0.0001) at 1 h postinjection.
2 context sentences(design, population, supporting numbers)
Summary · context
Cannulae were inserted into the rat hypothalamic paraventricular (PVN), arcuate (Arc), dorsomedial (DMN), and ventromedial (VMN) nuclei; the medial preoptic (MPO), anterior hypothalamic (AHA), and lateral hypothalamic (LHA) areas; and the extrahypothalamic central nucleus of the amygdala (CeA).
Summary · context
Agrp (83-132) (0.1 nmol) and [Nle4, D-Phe7]alpha(-MSH (NDP-MSH) (0.1 nmol), a stable alpha-MSH analog, were administered to fed and fasted rats, respectively.
Report a problemFND-1086893201
02AnimalAnimal study (in vivo)Efficacy outcome
In fasted rats, NDP-MSH injected into the dorsomedial nucleus decreased food intake by 44% at 1 h postinjection.
In plain wordsIn rats, NDP-MSH given into one brain area cut food intake by about two fifths.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseFood intake after NDP-MSH in DMN
Study
ratn: not reported in source
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
0.1 nmol · cannula injection into hypothalamic nucleiAs given in this study (rat).
Measurements
Food intake reduction
44%
DMN, 1 h
Source sentences
Summary
NDP-MSH decreased food intake in the PVN by 52 +/- 6% (P < 0.005), in the DMN by 44 +/- 6% (P < 0.0001), and in the MPO by 55 +/- 6% (P < 0.0001) at 1 h postinjection.
2 context sentences(design, population, supporting numbers)
Summary · context
Cannulae were inserted into the rat hypothalamic paraventricular (PVN), arcuate (Arc), dorsomedial (DMN), and ventromedial (VMN) nuclei; the medial preoptic (MPO), anterior hypothalamic (AHA), and lateral hypothalamic (LHA) areas; and the extrahypothalamic central nucleus of the amygdala (CeA).
Summary · context
Agrp (83-132) (0.1 nmol) and [Nle4, D-Phe7]alpha(-MSH (NDP-MSH) (0.1 nmol), a stable alpha-MSH analog, were administered to fed and fasted rats, respectively.
Report a problemFND-1086893202
03AnimalAnimal study (in vivo)Efficacy outcome
In fasted rats, NDP-MSH injected into the medial preoptic area decreased food intake by 55% at 1 h postinjection.
In plain wordsIn rats, NDP-MSH given into one brain area cut food intake by about half.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseFood intake after NDP-MSH in MPO
Study
ratn: not reported in source
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
0.1 nmol · cannula injection into hypothalamic nucleiAs given in this study (rat).
Measurements
Food intake reduction
55%
MPO, 1 h
Source sentences
Summary
NDP-MSH decreased food intake in the PVN by 52 +/- 6% (P < 0.005), in the DMN by 44 +/- 6% (P < 0.0001), and in the MPO by 55 +/- 6% (P < 0.0001) at 1 h postinjection.
2 context sentences(design, population, supporting numbers)
Summary · context
Cannulae were inserted into the rat hypothalamic paraventricular (PVN), arcuate (Arc), dorsomedial (DMN), and ventromedial (VMN) nuclei; the medial preoptic (MPO), anterior hypothalamic (AHA), and lateral hypothalamic (LHA) areas; and the extrahypothalamic central nucleus of the amygdala (CeA).
Summary · context
Agrp (83-132) (0.1 nmol) and [Nle4, D-Phe7]alpha(-MSH (NDP-MSH) (0.1 nmol), a stable alpha-MSH analog, were administered to fed and fasted rats, respectively.
Report a problemFND-1086893203
04AnimalAnimal study (in vivo)Efficacy outcome
In fasted rats, NDP-MSH injected into the arcuate nucleus suppressed food intake.
In plain wordsIn rats, NDP-MSH given into one brain area reduced food intake.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseFood intake after NDP-MSH in arcuate nucleus
Study
ratn: not reported in source
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
0.1 nmol · cannula injection into hypothalamic nucleiAs given in this study (rat).
Source sentences
Summary
NDP-MSH suppressed food intake in the Arc and LHA.
2 context sentences(design, population, supporting numbers)
Summary · context
Cannulae were inserted into the rat hypothalamic paraventricular (PVN), arcuate (Arc), dorsomedial (DMN), and ventromedial (VMN) nuclei; the medial preoptic (MPO), anterior hypothalamic (AHA), and lateral hypothalamic (LHA) areas; and the extrahypothalamic central nucleus of the amygdala (CeA).
Summary · context
Agrp (83-132) (0.1 nmol) and [Nle4, D-Phe7]alpha(-MSH (NDP-MSH) (0.1 nmol), a stable alpha-MSH analog, were administered to fed and fasted rats, respectively.
Report a problemFND-1086893204
05AnimalAnimal study (in vivo)Efficacy outcome
In fasted rats, NDP-MSH injected into the lateral hypothalamic area suppressed food intake.
In plain wordsIn rats, NDP-MSH given into one brain area reduced food intake.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseFood intake after NDP-MSH in lateral hypothalamic area
Study
ratn: not reported in source
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
0.1 nmol · cannula injection into hypothalamic nucleiAs given in this study (rat).
Source sentences
Summary
NDP-MSH suppressed food intake in the Arc and LHA.
2 context sentences(design, population, supporting numbers)
Summary · context
Cannulae were inserted into the rat hypothalamic paraventricular (PVN), arcuate (Arc), dorsomedial (DMN), and ventromedial (VMN) nuclei; the medial preoptic (MPO), anterior hypothalamic (AHA), and lateral hypothalamic (LHA) areas; and the extrahypothalamic central nucleus of the amygdala (CeA).
Summary · context
Agrp (83-132) (0.1 nmol) and [Nle4, D-Phe7]alpha(-MSH (NDP-MSH) (0.1 nmol), a stable alpha-MSH analog, were administered to fed and fasted rats, respectively.
Report a problemFND-1086893205

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Journal Article

MeSH terms

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