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Study · Animal study (in vivo) · rat · 2000

8 results

Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats.

Szayna M, Doyle ME, Betkey JA, Holloway HW, Spencer RG, Greig NH, Egan JM

Endocrinology1 Jun 2000Cited by 228 (Europe PMC)

PMID10830274 (opens in a new tab)DOI10.1210/endo.141.6.7490 (opens in a new tab)PepBankPUB-10830274
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, once-daily exendin‑4 initially reduced food intake, which matched untreated animals after 5 days.

    In plain wordsIn rats, exendin‑4 initially reduced food intake, but intake matched untreated rats after 5 days.

    Peptide
    Exenatide (exendin-4)
    Outcome
    MixedFood intake during once-daily injections
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    We observed an immediate reduction in food intake which then leveled off(after 5 days) to match that of the untreated animals.
    1 context sentence
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, twice-daily exendin‑4 produced a sustained reduction in food intake.

    In plain wordsIn rats, twice-daily exendin‑4 sustained lower food intake than in untreated rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFood intake during twice-daily injections
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 56 days in totalAs given in this study (rat).

    Source sentences

    Summary
    Subsequently we injected the same animals twice daily (treatment period of 56 days in total) and observed a sustained reduction in food intake and weight-gain.
    1 context sentence
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, twice-daily exendin‑4 reduced weight gain.

    In plain wordsIn rats, twice-daily exendin‑4 reduced weight gain compared with untreated rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseWeight gain
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 56 days in totalAs given in this study (rat).

    Source sentences

    Summary
    Subsequently we injected the same animals twice daily (treatment period of 56 days in total) and observed a sustained reduction in food intake and weight-gain.
    1 context sentence
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, exendin‑4 reduced HbA1c.

    In plain wordsIn rats, exendin‑4 reduced HbA1c compared with untreated rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseHbA1c
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 56 days in totalAs given in this study (rat).

    Source sentences

    Summary
    This was matched by a reduction in the critical parameters of HbA1c, fasting blood glucose and plasma insulin.
    2 context sentences
    Summary · context
    Subsequently we injected the same animals twice daily (treatment period of 56 days in total) and observed a sustained reduction in food intake and weight-gain.
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, exendin‑4 reduced fasting blood glucose.

    In plain wordsIn rats, exendin‑4 reduced fasting blood glucose compared with untreated rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFasting blood glucose
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 56 days in totalAs given in this study (rat).

    Source sentences

    Summary
    This was matched by a reduction in the critical parameters of HbA1c, fasting blood glucose and plasma insulin.
    2 context sentences
    Summary · context
    Subsequently we injected the same animals twice daily (treatment period of 56 days in total) and observed a sustained reduction in food intake and weight-gain.
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, exendin‑4 reduced plasma insulin.

    In plain wordsIn rats, exendin‑4 reduced blood insulin compared with untreated rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreasePlasma insulin
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 56 days in totalAs given in this study (rat).

    Source sentences

    Summary
    This was matched by a reduction in the critical parameters of HbA1c, fasting blood glucose and plasma insulin.
    2 context sentences
    Summary · context
    Subsequently we injected the same animals twice daily (treatment period of 56 days in total) and observed a sustained reduction in food intake and weight-gain.
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, exendin‑4 reduced subcutaneous fat deposition after 4 weeks.

    In plain wordsIn rats, exendin‑4 reduced fat under the skin compared with untreated rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseSubcutaneous fat deposition
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    MRI imaging of the abdominal regions of the animals showed that initially only the amount of fat deposited in the sc region was reduced after 4 weeks exendin-4 treatment.
    1 context sentence
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker fatty rats, exendin‑4 reduced visceral fat deposition at 8 weeks.

    In plain wordsIn rats, exendin‑4 reduced visceral fat compared with untreated rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseVisceral fat deposition
    Study

    ratn: not reported in source

    Zucker fatty rats
    Comparator
    untreated animals
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    At the 8-week time point there was a corresponding decrease in the amount of visceral fat deposition.
    2 context sentences
    Summary · context
    MRI imaging of the abdominal regions of the animals showed that initially only the amount of fat deposited in the sc region was reduced after 4 weeks exendin-4 treatment.
    Summary · context
    In this study, we initially examined the effect of once daily injections (over 14 days) on the food consumption of Zucker fatty rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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