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Study · Non-randomized trial · n = 12 · 2000

3 results

Role of food intake in the modulation of hexarelin-induced growth hormone release in normal human subjects.

De Marinis L, Mancini A, Valle D, Izzi D, Bianchi A, Gentilella R, Giampietro A, Desenzani P, Giustina A

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme1 Apr 2000Cited by 3 (Europe PMC)

PMID10824712 (opens in a new tab)DOI10.1055/s-2007-978611 (opens in a new tab)PepBankPUB-10824712
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six normal men and six normal women in the fasting state, hexarelin released more growth hormone than GHRH (GH-AUC 3010 versus 1339 microg/L/120 min; p<0.06).

    In plain wordsIn healthy adults who had not eaten, hexarelin released more growth hormone than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH release (AUC) after hexarelin versus GHRH, fasting
    Study

    n = 12

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GH-AUC
    3010 microg/L/120 min
    hexarelin, fasting
    GH-AUC
    1339 microg/L/120 min
    GHRH, fasting

    Source sentences

    Summary
    HEX is much more powerful than GHRH in inducing GH release in humans, both in the fasting state (GH-AUC: 3010 +/- 695 after HEX, vs. 1339 +/- 281 after GHRH, microg/L/120 min; p<0.06)
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the effect of food ingestion on GH secretion induced by HEX as compared to GHRH in six normal men (aged 23-29 years) and six normal women (aged 24-29 years).
  2. 02HumanNon-randomized trialEfficacy outcome

    In six normal men and six normal women after a meal, hexarelin released more growth hormone than GHRH (GH-AUC 1523 versus 309 microg/L/120 min; p<0.06).

    In plain wordsIn healthy adults after a meal, hexarelin released more growth hormone than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH release (AUC) after hexarelin versus GHRH, after a meal
    Study

    n = 12

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GH-AUC
    1523 microg/L/120 min
    hexarelin, after meal
    GH-AUC
    309 microg/L/120 min
    GHRH, after meal

    Source sentences

    Summary
    and after a meal (GH-AUC: 1523 +/- 121, after HEX, vs. 309 +/- 61, after GHRH, microg/L/120 min; p<0.06).
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the effect of food ingestion on GH secretion induced by HEX as compared to GHRH in six normal men (aged 23-29 years) and six normal women (aged 24-29 years).
  3. 03HumanNon-randomized trialEfficacy outcome

    In six normal men and six normal women, a meal partially blunted the GH response to hexarelin (GH-AUC 3010 fasting versus 1523 after a meal microg/L/120 min; mean inhibition 41.02%).

    In plain wordsIn healthy adults, eating a meal reduced part of the growth hormone response to hexarelin compared with fasting.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of a meal on the GH response to hexarelin
    Study

    n = 12

    Comparator
    Hexarelin in the fasting state
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GH-AUC
    3010 microg/L/120 min
    hexarelin, fasting
    GH-AUC
    1523 microg/L/120 min
    hexarelin, after meal
    Mean inhibition of AUC
    41.02%
    hexarelin

    Source sentences

    Summary
    food intake partially blunts the fasting GH response to HEX (GH-AUC: 3010 +/- 695 after HEX, in fasting state, vs. 1523 +/- 121 after HEX, after meal, microg/L/120 min; p<0.06; mean inhibition of AUC 41.02 +/- 7.96%)
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the effect of food ingestion on GH secretion induced by HEX as compared to GHRH in six normal men (aged 23-29 years) and six normal women (aged 24-29 years).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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