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Study · Non-randomized trial · n = 11 · 2000

5 results

The negative GH auto-feedback in childhood: effects of rhGH and/or GHRH on the somatotroph response to GHRH or hexarelin, a peptidyl GH secretagogue, in children.

Bellone J, Bellone S, Aimaretti G, Valetto MR, Baffoni C, Corneli G, Origlia C, Arvat E, Ghigo E

Journal of endocrinological investigation1 Mar 2000Cited by 3 (Europe PMC)

PMID10803472 (opens in a new tab)DOI10.1007/bf03343699 (opens in a new tab)PepBankPUB-10803472
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialMechanism

    In prepubertal children with normal short stature, pre-treatment with GHRH did not change the GH response to a later GHRH dose.

    In plain wordsIn short children of normal growth rate, an earlier GHRH dose did not change the growth hormone response to a second GHRH dose.

    Peptide
    Sermorelin
    Outcome
    No significant changeGH response to GHRH after GHRH pre-treatment
    Study

    n = 11

    Comparator
    Saline pre-treatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    In group A, the GH response to GHRH was not modified by pre-treatment with GHRH (GH peak, mean+/-SEM: 16.7+/-2.9 vs 15.1+/-2.3 microg/l, respectively)
    1 context sentence
    Summary · context
    To this goal we studied the effects of rhGH and/or GHRH administration on the GH response to GHRH or hexarelin (HEX), a peptidyl GH secretagogue, in normal short children.
  2. 02HumanNon-randomized trialMechanism

    In prepubertal children with normal short stature, adding GHRH to rhGH pre-treatment did not significantly change the GH response to a GHRH test dose.

    In plain wordsIn short children of normal growth rate, adding GHRH to a growth hormone pre-dose did not significantly change the growth hormone response to GHRH.

    Peptide
    Sermorelin
    Outcome
    No significant changeGH response to GHRH after rhGH plus GHRH pre-treatment
    Study

    n = 6

    Comparator
    rhGH pre-treatment alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · intravenousAs given in this study (human).

    Measurements

    GH peak
    6.9 microg/l
    after rhGH plus GHRH pre-treatment
    GH peak
    13.2 microg/l
    after rhGH pre-treatment alone

    Source sentences

    Summary
    In group C, the GH response to GHRH after pre-treatment with rhGH (13.2+/-4.0 microg/l) was similar to that in group B and was not significantly modified by pre-treatment with rhGH+ GHRH (6.9+/-2.7 microg/l)
    1 context sentence
    Summary · context
    To this goal we studied the effects of rhGH and/or GHRH administration on the GH response to GHRH or hexarelin (HEX), a peptidyl GH secretagogue, in normal short children.
  3. 03HumanNon-randomized trialMechanism

    In prepubertal children with normal short stature, the GH rise after rhGH plus GHRH was higher than after rhGH alone.

    In plain wordsIn short children of normal growth rate, growth hormone rose more after growth hormone plus GHRH than after growth hormone alone.

    Peptide
    Sermorelin
    Outcome
    IncreaseGH rise after rhGH plus GHRH versus rhGH alone
    Study

    n = 6

    Comparator
    rhGH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the GH rise after rhGH+GHRH was higher (p<0.05) than that after rhGH alone.
    1 context sentence
    Summary · context
    To this goal we studied the effects of rhGH and/or GHRH administration on the GH response to GHRH or hexarelin (HEX), a peptidyl GH secretagogue, in normal short children.

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 04HumanNot a test of Sermorelin aloneNon-randomized trialMechanism

    In prepubertal children with normal short stature, pre-treatment with rhGH inhibited the GH response to a GHRH test dose; GHRH was the test stimulus.

    In plain wordsIn short children of normal growth rate, growth hormone given first reduced the growth hormone response to a GHRH test dose.

    Peptide
    Sermorelin
    Outcome
    DecreaseGH response to GHRH after rhGH pre-treatment
    Study

    n = 6

    Comparator
    Saline pre-treatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    8.7 microg/l
    after rhGH pre-treatment
    GH peak
    38.8 microg/l
    after saline pre-treatment

    Source sentences

    Summary
    In group B, the GH response to GHRH was clearly inhibited by rhGH (8.7+/-2.3 vs 38.8+/-4.5 microg/l, p<0.001)
    1 context sentence
    Summary · context
    To this goal we studied the effects of rhGH and/or GHRH administration on the GH response to GHRH or hexarelin (HEX), a peptidyl GH secretagogue, in normal short children.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  2. 05HumanNot a test of Hexarelin aloneOther designMechanism

    In normal short children, pretreatment with rhGH significantly blunted the GH peak response to hexarelin (34.1 vs 51.2 microg/l).

    In plain wordsIn short children, growth hormone given first lowered the growth hormone surge that hexarelin caused.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin after rhGH pretreatment
    Study

    n = 6

    Comparator
    Hexarelin alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak after rhGH then HEX
    34.1 microg/l
    group D
    GH peak after HEX alone
    51.2 microg/l
    group D

    Source sentences

    Summary
    In group D, the GH response to HEX was significantly blunted by pre-treatment with rhGH (34.1+/-11.7 vs 51.2+/-17.9 microg/l, p<0.05).
    2 context sentences
    Summary · context
    group D (no.=6): HEX (2 microg/kg iv at 150 min) alone or preceded by rhGH.
    Summary · context
    To this goal we studied the effects of rhGH and/or GHRH administration on the GH response to GHRH or hexarelin (HEX), a peptidyl GH secretagogue, in normal short children.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 19:08 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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