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Study · Animal study (in vivo) · rat · 2000

6 results

The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats. A comparison with antidepressants.

Sikiric P, Separovic J, Buljat G, Anic T, Stancic-Rokotov D, Mikus D, Marovic A, Prkacin I, Duplancic B, Zoricic I, Aralica G, Lovric-Bencic M and 11 more

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Ziger T, Perovic D, Rotkvic I, Mise S, Hanzevacki M, Hahn V, Seiwerth S, Turkovic B, Grabarevic Z, Petek M, Rucman R

Journal of physiology, Paris1 Mar 2000Cited by 22 (Europe PMC)

PMID10791689 (opens in a new tab)DOI10.1016/s0928-4257(00)00148-0 (opens in a new tab)PepBankPUB-10791689
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the forced swimming test, BPC‑157 reduced immobility time to a degree that corresponds to the activity of imipramine.

    In plain wordsIn rats, BPC‑157 reduced immobility in the swim test about as much as the antidepressant imipramine.

    Peptide
    BPC-157
    Outcome
    DecreaseImmobility time in forced swimming test, versus imipramine
    Study

    ratn: not reported in source

    Forced swimming (Porsolt) test
    Comparator
    Imipramine 15 mg
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg and 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In a forced swimming test, a reduction of the immobility time in BPC 157 (10 microg, 10 ng x kg(-1) i.p.) treated rats corresponds to the activity of the 15 mg or 40 mg (i.p.) of conventional antidepressants, imipramine or nialamide, respectively, given according to the original Porsolt's protocol.
    1 context sentence
    Summary · context
    First, a forced swimming test (a Porsolt's procedure) was used.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the forced swimming test, BPC‑157 reduced immobility time to a degree that corresponds to the activity of nialamide.

    In plain wordsIn rats, BPC‑157 reduced immobility in the swim test about as much as the antidepressant nialamide.

    Peptide
    BPC-157
    Outcome
    DecreaseImmobility time in forced swimming test, versus nialamide
    Study

    ratn: not reported in source

    Forced swimming (Porsolt) test
    Comparator
    Nialamide 40 mg
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg and 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In a forced swimming test, a reduction of the immobility time in BPC 157 (10 microg, 10 ng x kg(-1) i.p.) treated rats corresponds to the activity of the 15 mg or 40 mg (i.p.) of conventional antidepressants, imipramine or nialamide, respectively, given according to the original Porsolt's protocol.
    1 context sentence
    Summary · context
    First, a forced swimming test (a Porsolt's procedure) was used.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats, BPC‑157 reduced immobility after 4 days of medication.

    In plain wordsIn stressed rats, BPC‑157 reduced immobility after 4 days.

    Peptide
    BPC-157
    Outcome
    DecreaseImmobility after 4 days of medication, chronic unpredictable stress
    Study

    ratn: not reported in source

    Chronic unpredictable stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg and 10 ng/kg · intraperitoneal · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    In these conditions, no delay in the effectiveness was noted in BPC 157 medication and a reduction of the immobility of chronically stressed rats was noted after both 4 and 6 d of BPC 157 (10 microg, 10 ng) medication.
    1 context sentence
    Summary · context
    As a more severe procedure, chronic unpredictable stress (after 5 d of unpredictable stress protocol, once daily drug application during stress procedure, open field-immobility test assessment at fourth or sixth day of medication) was used.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats, BPC‑157 reduced immobility after 6 days of medication.

    In plain wordsIn stressed rats, BPC‑157 reduced immobility after 6 days.

    Peptide
    BPC-157
    Outcome
    DecreaseImmobility after 6 days of medication, chronic unpredictable stress
    Study

    ratn: not reported in source

    Chronic unpredictable stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg and 10 ng/kg · intraperitoneal · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    In these conditions, no delay in the effectiveness was noted in BPC 157 medication and a reduction of the immobility of chronically stressed rats was noted after both 4 and 6 d of BPC 157 (10 microg, 10 ng) medication.
    1 context sentence
    Summary · context
    As a more severe procedure, chronic unpredictable stress (after 5 d of unpredictable stress protocol, once daily drug application during stress procedure, open field-immobility test assessment at fourth or sixth day of medication) was used.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats, BPC‑157 showed no delay in effectiveness, whereas imipramine worked only after a longer period.

    In plain wordsIn stressed rats, BPC‑157 worked without delay, while imipramine took longer to work.

    Peptide
    BPC-157
    Outcome
    No significant changeDelay in onset of effect versus imipramine
    Study

    ratn: not reported in source

    Chronic unpredictable stress
    Comparator
    Imipramine 30 mg
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg and 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In these conditions, no delay in the effectiveness was noted in BPC 157 medication and a reduction of the immobility of chronically stressed rats was noted after both 4 and 6 d of BPC 157 (10 microg, 10 ng) medication.
    1 context sentence
    Summary · context
    The effect of daily imipramine (30 mg) medication could be seen only after a more prolonged period, but not after a shorter period (i.e., 4-d protocol).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats under aggravated chronic unpredictable stress, the activity of conventional antidepressants was markedly affected, whereas the effectiveness of BPC‑157 was continuously present.

    In plain wordsIn stressed rats, BPC‑157 kept working under harsher stress conditions, while the effect of conventional antidepressants was markedly affected.

    Peptide
    BPC-157
    Outcome
    Direction not reportedAntidepressant-like effect under aggravated chronic unpredictable stress, versus conventional antidepressants
    Study

    ratn: not reported in source

    Chronic unpredictable stress
    Comparator
    Conventional antidepressants
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In chronic unpredictable stress procedure, particular aggravation of experimental conditions markedly affected the conventional antidepressant activity, whereas BPC 157 effectiveness was continuously present.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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