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Study · Observational study · 2000

6 results

Comparisons among old and new provocative tests of GH secretion in 178 normal adults.

Aimaretti G, Baffoni C, DiVito L, Bellone S, Grottoli S, Maccario M, Arvat E, Camanni F, Ghigo E

European journal of endocrinology1 Apr 2000Cited by 71 (Europe PMC)

PMID10754475 (opens in a new tab)DOI10.1530/eje.0.1420347 (opens in a new tab)PepBankPUB-10754475
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In normal adults, intravenous hexarelin produced a mean peak GH response of 55.3 microg/l.

    In plain wordsIn healthy adults, a hexarelin injection raised growth hormone to a mean peak of 55.3 micrograms per litre.

    Peptide
    Hexarelin
    Outcome
    IncreasePeak GH response to hexarelin
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenous · single doseAs given in this study (human).

    Measurements

    peak GH response
    55.3 microg/l
    HEX 2 microg/kg i.v.
    peak GH response range
    13.9 to 163.5 microg/l
    HEX 2 microg/kg i.v.

    Source sentences

    Summary
    The GH response to HEX (55.3+/-5.5, range: 13.9-163.5 microg/l)
    1 context sentence
    Summary · context
    in 178 normal adults (95 males, 83 females; age range: 20-50 years, all within +/-15% of their ideal body weight)
  2. 02HumanObservational studyEfficacy outcome

    In normal adults, the GH response to hexarelin was similar to that after GHRH+ARG and GHRH+PD.

    In plain wordsIn healthy adults, hexarelin raised growth hormone about as much as two combined tests did.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin versus GHRH+ARG and GHRH+PD
    Study

    n: not reported in source

    Comparator
    GHRH+ARG and GHRH+PD
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    The GH response to HEX (55.3+/-5.5, range: 13.9-163.5 microg/l) was similar to those after GHRH+ARG and GHRH+PD
    1 context sentence
    Summary · context
    in 178 normal adults (95 males, 83 females; age range: 20-50 years, all within +/-15% of their ideal body weight)
  3. 03HumanObservational studyEfficacy outcome

    In normal adults, the GH response to hexarelin alone was lower than that after GHRH with low-dose hexarelin (GHRH+HEX).

    In plain wordsIn healthy adults, hexarelin alone raised growth hormone less than the GHRH and hexarelin test.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin versus GHRH+HEX
    Study

    n: not reported in source

    Comparator
    GHRH+HEX
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    but lower (P<0.001) than that after GHRH+HEX (86.0+/-4.3, range: 49.
    1 context sentence
    Summary · context
    in 178 normal adults (95 males, 83 females; age range: 20-50 years, all within +/-15% of their ideal body weight)
  4. 04HumanObservational studyEfficacy outcome

    In normal adults, the third centile limit of the peak GH response to hexarelin was 21.6.

    In plain wordsIn healthy adults, the lower limit of the normal growth hormone response to hexarelin was 21.6.

    Peptide
    Hexarelin
    Outcome
    Not applicableThird centile limit of peak GH response to hexarelin
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenous · single doseAs given in this study (human).

    Measurements

    third centile limit of peak GH response
    21.6 microg/l
    HEX

    Source sentences

    Summary
    HEX: 21.6
    1 context sentence
    Summary · context
    in 178 normal adults (95 males, 83 females; age range: 20-50 years, all within +/-15% of their ideal body weight)

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 05HumanNot a test of Hexarelin aloneObservational studyEfficacy outcome

    In normal adults, GHRH combined with low-dose hexarelin produced a mean peak GH response of 86.0 microg/l and was the most potent stimulus of GH secretion.

    In plain wordsIn healthy adults, GHRH combined with a low hexarelin dose gave the largest growth hormone rise of all tests.

    Peptide
    Hexarelin
    Outcome
    IncreasePeak GH response to GHRH+HEX
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    peak GH response
    86 microg/l
    GHRH+HEX
    peak GH response range
    49 to 125 microg/l
    GHRH+HEX

    Source sentences

    Summary
    The GH response to HEX (55.3+/-5.5, range: 13.9-163.5 microg/l) was similar to those after GHRH+ARG and GHRH+PD but lower (P<0.001) than that after GHRH+HEX (86.0+/-4.3, range: 49. 0-125.0 microg/l) which was the most potent stimulus of GH secretion.
    1 context sentence
    Summary · context
    in 178 normal adults (95 males, 83 females; age range: 20-50 years, all within +/-15% of their ideal body weight)

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 06HumanNot a test of Hexarelin aloneObservational studyEfficacy outcome

    In normal adults, the third centile limit of the peak GH response to GHRH plus low-dose hexarelin was 57.1.

    In plain wordsIn healthy adults, the lower limit of the normal growth hormone response to GHRH plus hexarelin was 57.1.

    Peptide
    Hexarelin
    Outcome
    Not applicableThird centile limit of peak GH response to GHRH+HEX
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    third centile limit of peak GH response
    57.1 microg/l
    GHRH+HEX

    Source sentences

    Summary
    GHRH+HEX: 57.1
    1 context sentence
    Summary · context
    in 178 normal adults (95 males, 83 females; age range: 20-50 years, all within +/-15% of their ideal body weight)

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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