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Study · Animal study (in vivo) · mouse · 1999

3 results

The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam.

Jelovac N, Sikiric P, Rucman R, Petek M, Perovic D, Marovic A, Anic T, Seiwerth S, Mise S, Pigac B, Duplancie B, Turkovic B and 8 more

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Dodig G, Prkacin I, Stancic-Rokotov D, Zoricic I, Aralica G, Sebecic B, Ziger T, Slobodnjak Z

The Chinese journal of physiology1 Sept 1999Cited by 9 (Europe PMC)

PMID10707891 (opens in a new tab)DOI10.1016/s0924-977x(99)90186-4 (opens in a new tab)PepBankPUB-10707891
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice chronically treated with diazepam, co-administered BPC‑157 completely avoided the diazepam tolerance hallmark of shorter preconvulsive latency.

    In plain wordsIn mice on long-term diazepam, adding BPC‑157 prevented loss of diazepam effect (tolerance).

    Peptide
    BPC-157
    Outcome
    DecreaseDiazepam tolerance (shorter preconvulsive latency)
    Study

    mousen: not reported in source

    chronic diazepam tolerance and dependence assays
    Comparator
    Diazepam alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal · 10 daysAs given in this study (mouse).

    Source sentences

    Summary
    This was completely avoided in diazepam+BPC 157 10 microg or diazepam+BPC 157 10 ng chronically treated animals.
    1 context sentence
    Summary · context
    if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice conditioned with diazepam plus BPC‑157 (10 µg), residual anticonvulsive activity (longer latency to isoniazid convulsion) was present at 6 h, unlike with diazepam alone.

    In plain wordsIn mice, adding BPC‑157 to diazepam kept some protection against convulsions at 6 hours after treatment ended.

    Peptide
    BPC-157
    Outcome
    IncreaseResidual anticonvulsive activity at 6 h after diazepam conditioning
    Study

    mousen: not reported in source

    chronic diazepam tolerance and dependence assays
    Comparator
    Diazepam alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal · 10 daysAs given in this study (mouse).

    Source sentences

    Summary
    In diazepam+BPC 157 10 microg- conditioned mice, a residual anticonvulsive activity (i.e., longer latency to isoniazid convulsion) was noted at 6 h post-conditioning
    1 context sentence
    Summary · context
    in diazepam conditioned mice residual anticonvulsive activity was not present already at the earliest post-conditioning interval (i.e., not different latency to isoniazid-convulsions)
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice conditioned with diazepam plus BPC‑157 (10 µg), shorter preconvulsive latencies, the withdrawal hallmark, appeared only at 72 h, whereas diazepam alone showed them from 42 h.

    In plain wordsIn mice, adding BPC‑157 to diazepam delayed signs of withdrawal compared with diazepam alone.

    Peptide
    BPC-157
    Outcome
    DecreasePhysical dependence/withdrawal (shorter preconvulsive latency)
    Study

    mousen: not reported in source

    chronic diazepam tolerance and dependence assays
    Comparator
    Diazepam alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal · 10 daysAs given in this study (mouse).

    Source sentences

    Summary
    In diazepam+BPC 157 10 microg- conditioned mice, a residual anticonvulsive activity (i.e., longer latency to isoniazid convulsion) was noted at 6 h post-conditioning, whereas shorter preconvulsive latencies appeared only at 72 h-post-conditioning period.
    1 context sentence
    Summary · context
    whereas shorter preconvulsive latencies (as physical dependence/withdrawal hallmark) were noted in diazepam conditioned mice following isoniazid challenge at 42 h and at 72 h after end of conditioning treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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