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Study · Not a test of the peptide alone · 2000

5 results

Adult height in short normal girls treated with gonadotropin-releasing hormone analogs and growth hormone.

Pasquino AM, Pucarelli I, Roggini M, Segni M

The Journal of clinical endocrinology and metabolism1 Feb 2000Cited by 49 (Europe PMC)

PMID10690865 (opens in a new tab)DOI10.1210/jcem.85.2.6387 (opens in a new tab)PepBankPUB-10690865
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In short girls, adult height after GH plus triptorelin exceeded pretreatment predicted adult height by a mean of 10 cm, and adult height also exceeded it after GH alone (gain 6.1 cm).

    In plain wordsIn short girls, adult height was above the earlier prediction with GH plus triptorelin and also with GH alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseAdult height versus predicted height
    Study

    n = 12

    Comparator
    Pretreatment
    Outcome group
    Linear growth · Endocrine and hormones

    Measurements

    Adult height
    156.3 cm
    GH plus GnRHa
    Pretreatment predicted adult height
    146.3 cm
    GH plus GnRHa
    Height gain
    10 cm
    adult height minus pretreatment prediction

    Source sentences

    Summary
    Patients in the group treated with GH plus GnRHa showed an adult height significantly higher (P < 0.001) than the pretreatment PAH (156.3 +/- 5.9 vs. 146.3 +/- 5 cm); the gain in centimeters calculated between pretreatment PAH and adult height was 10 +/- 2.9 cm, and 7 of 12 girls had a gain over 10 cm.
    2 context sentences
    Summary · context
    We treated 12 girls with idiopathic short stature and normal or early puberty with GH and GnRHa and followed them to adult height; 12 girls comparable for auxological and laboratory characteristics treated with GH alone served to better evaluate the efficacy of addition of GnRHa.
    Summary · context
    GH was given at a dose of 0.3 mg/kg x week, sc, 6 days weekly, and GnRHa (depot-triptorelin) was given at a dose of 100 microg/kg every 21 days, im.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In short girls receiving GH plus triptorelin, 7 of 12 exceeded their pretreatment predicted adult height by more than 10 cm.

    In plain wordsIn short girls receiving GH plus triptorelin, 7 of 12 exceeded their predicted adult height by more than 10 cm.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableHeight gain over 10 cm
    Study

    n = 12

    Outcome group
    Linear growth · Endocrine and hormones

    Measurements

    Girls with height gain over 10 cm
    7 girls
    GH plus GnRHa (of 12)

    Source sentences

    Summary
    Patients in the group treated with GH plus GnRHa showed an adult height significantly higher (P < 0.001) than the pretreatment PAH (156.3 +/- 5.9 vs. 146.3 +/- 5 cm); the gain in centimeters calculated between pretreatment PAH and adult height was 10 +/- 2.9 cm, and 7 of 12 girls had a gain over 10 cm.
    2 context sentences
    Summary · context
    We treated 12 girls with idiopathic short stature and normal or early puberty with GH and GnRHa and followed them to adult height; 12 girls comparable for auxological and laboratory characteristics treated with GH alone served to better evaluate the efficacy of addition of GnRHa.
    Summary · context
    GH was given at a dose of 0.3 mg/kg x week, sc, 6 days weekly, and GnRHa (depot-triptorelin) was given at a dose of 100 microg/kg every 21 days, im.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In short girls receiving GH plus triptorelin, adult height significantly exceeded target height.

    In plain wordsIn short girls receiving GH plus triptorelin, adult height significantly exceeded target height.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseAdult height versus target height
    Study

    n = 12

    Comparator
    Target height
    Outcome group
    Linear growth · Endocrine and hormones

    Source sentences

    Summary
    Target height was significantly exceeded.
    2 context sentences
    Summary · context
    We treated 12 girls with idiopathic short stature and normal or early puberty with GH and GnRHa and followed them to adult height; 12 girls comparable for auxological and laboratory characteristics treated with GH alone served to better evaluate the efficacy of addition of GnRHa.
    Summary · context
    GH was given at a dose of 0.3 mg/kg x week, sc, 6 days weekly, and GnRHa (depot-triptorelin) was given at a dose of 100 microg/kg every 21 days, im.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  4. 04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In short girls receiving GH plus triptorelin, height SD score for bone age increased from -1.81 to -0.85.

    In plain wordsIn short girls receiving GH plus triptorelin, height scores for bone age increased compared with pretreatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseHeight SD score for bone age
    Study

    n = 12

    Comparator
    Pretreatment
    Outcome group
    Linear growth · Endocrine and hormones

    Measurements

    Height SD score for bone age
    −1.81 SD score
    pretreatment
    Height SD score for bone age
    −0.85 SD score
    after GH plus GnRHa

    Source sentences

    Summary
    Height SD score for BA increased from - 1.81 +/-0.8 to -0.85 +/- 1.0.
    2 context sentences
    Summary · context
    We treated 12 girls with idiopathic short stature and normal or early puberty with GH and GnRHa and followed them to adult height; 12 girls comparable for auxological and laboratory characteristics treated with GH alone served to better evaluate the efficacy of addition of GnRHa.
    Summary · context
    GH was given at a dose of 0.3 mg/kg x week, sc, 6 days weekly, and GnRHa (depot-triptorelin) was given at a dose of 100 microg/kg every 21 days, im.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  5. 05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialSafety outcome

    In short girls receiving GH plus triptorelin, no adverse effects were observed, as in the GH-alone group.

    In plain wordsIn short girls, neither GH plus triptorelin nor GH alone produced observed adverse effects.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeAdverse effects
    Study

    n = 12

    Outcome group
    Adverse events · Endocrine and hormones

    Source sentences

    Summary
    No adverse effects were observed in either group.
    2 context sentences
    Summary · context
    We treated 12 girls with idiopathic short stature and normal or early puberty with GH and GnRHa and followed them to adult height; 12 girls comparable for auxological and laboratory characteristics treated with GH alone served to better evaluate the efficacy of addition of GnRHa.
    Summary · context
    GH was given at a dose of 0.3 mg/kg x week, sc, 6 days weekly, and GnRHa (depot-triptorelin) was given at a dose of 100 microg/kg every 21 days, im.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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