In rats with subcutaneous sponge implants, BPC‑157 markedly increased the number of newly formed endothelial spaces in granulation tissue compared with control, after 3 or 7 days.
In plain wordsIn rats, BPC‑157 increased new blood vessel spaces in healing tissue compared with controls.
- Peptide
- BPC-157
- Outcome
- IncreaseNewly formed endothelial spaces in granulation tissue
- Study
ratn: not reported in source
subcutaneous sponge implantation angiogenesis model- Comparator
- Control
- Outcome group
- Wound healing · Skin and wound
- Studied dose
- 10 ng/mL, 10 µg/mL or 50 µg/kg · subcutaneous sponge implant · 3 or 7 daysAs given in this study (rat).
Source sentences
Compared with the control values, the number of newly formed endothelial spaces inside newly formed granulation tissue was markedly increased in all animals treated with BPC 157
2 context sentences(design, population, supporting numbers)
a consistent finding noted after either 3 or 7 d.
The sponges were removed after 3 or 7 d, fixed in formalin, and processed for histologic and histochemical evaluation and morphometry assessment.