In perfused human trabecular meshwork, elevated intraocular pressure upregulated the body's own thymosin-beta4 gene among 11 upregulated genes.
In plain wordsIn lab-kept human eye tissue, higher eye pressure raised the activity of the body's own thymosin-beta4 gene.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseThymosin-beta4 gene expression in trabecular meshwork under elevated pressure
- Study
humann: not reported in source
perfused human anterior segments (trabecular meshwork)- Comparator
- Control eye at baseline pressure
- Outcome group
- Gene expression · Eye
Source sentences
Eleven genes were found to be consistently upregulated in the human TM by elevated IOP: interleukin-6, preprotachykinin-1, secretogranin-II, cathepsin-L, stromelysin-1, thymosin-beta4, alpha-tubulin, alphaB-crystallin, glyceraldehyde-3-phosphate dehydrogenase, metallothionein and Cu/Zn superoxide dismutase.
2 context sentences(design, population, supporting numbers)
Two pairs of anterior segments of normal human eyes from postmortem donors were placed in culture and perfused 24 hours at constant flow (3 microl/min).
After reaching baseline, the flow of one eye from each pair was raised to obtain an incremental pressure (deltaP) of 50 mm Hg for 6 hours.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.