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Study · Animal study (in vivo) · mouse · 1999

4 results

Antimetastatic effect of desmopressin in a mouse mammary tumor model.

Alonso DF, Skilton G, Farías EF, Bal de Kier Joffé E, Gomez DE

Breast cancer research and treatment1 Oct 1999Cited by 26 (Europe PMC)

PMID10617303 (opens in a new tab)DOI10.1023/a:1006291607871 (opens in a new tab)PepBankPUB-10617303
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice inoculated with F3II carcinoma cells, DDAVP coinjection reduced pulmonary nodules about 70%.

    In plain wordsIn mice given F3II tumor cells, desmopressin reduced lung nodules about 70%.

    Peptide
    Desmopressin
    Outcome
    DecreaseF3II lung metastases
    Study

    mousen: not reported in source

    Syngeneic BALB/c mammary tumor model
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1-2 microg/kg body weightAs given in this study (mouse).

    Source sentences

    Summary
    In both cases, the number of pulmonary nodules was reduced about 70%.
    2 context sentences
    Summary · context
    Coinjection of DDAVP (1-2 microg/kg body weight) at the time of i.v. inoculation of F3II carcinoma cells or LM3 adenocarcinoma cells significantly inhibited the formation of experimental lung metastases.
    Summary · context
    We have investigated the effects of desmopressin (DDAVP), a synthetic analog of the natural hormone vasopressin, on experimental lung colonization of mammary tumor cells using a syngeneic BALB/c mouse model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice inoculated with LM3 adenocarcinoma cells, DDAVP coinjection reduced pulmonary nodules about 70%.

    In plain wordsIn mice given LM3 tumor cells, desmopressin reduced lung nodules about 70%.

    Peptide
    Desmopressin
    Outcome
    DecreaseLM3 lung metastases
    Study

    mousen: not reported in source

    Syngeneic BALB/c mammary tumor model
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1-2 microg/kg body weightAs given in this study (mouse).

    Source sentences

    Summary
    In both cases, the number of pulmonary nodules was reduced about 70%.
    2 context sentences
    Summary · context
    Coinjection of DDAVP (1-2 microg/kg body weight) at the time of i.v. inoculation of F3II carcinoma cells or LM3 adenocarcinoma cells significantly inhibited the formation of experimental lung metastases.
    Summary · context
    We have investigated the effects of desmopressin (DDAVP), a synthetic analog of the natural hormone vasopressin, on experimental lung colonization of mammary tumor cells using a syngeneic BALB/c mouse model.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DDAVP given 24 h after tumor-cell inoculation inhibited lung metastases.

    In plain wordsIn mice, desmopressin given 24 h after tumor-cell inoculation inhibited lung metastases.

    Peptide
    Desmopressin
    Outcome
    DecreaseLung metastases after delayed administration
    Study

    mousen: not reported in source

    Syngeneic BALB/c mammary tumor model
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    Inhibition of metastasis was also obtained with i.v. administration of DDAVP 24 h after tumor cell inoculation.
    1 context sentence
    Summary · context
    We have investigated the effects of desmopressin (DDAVP), a synthetic analog of the natural hormone vasopressin, on experimental lung colonization of mammary tumor cells using a syngeneic BALB/c mouse model.
  4. 04LabEx vivo tissueMechanism

    After mouse DDAVP dosing, plasma left tumor cells as single cells, unlike aggregation with control plasma.

    In plain wordsIn lab tests, plasma from desmopressin-treated mice prevented tumor-cell aggregation compared with plasma from control mice.

    Peptide
    Desmopressin
    Outcome
    DecreasePlasma-induced tumor-cell aggregation
    Study

    mousen: not reported in source

    Syngeneic BALB/c mammary tumor model
    Comparator
    Plasma from control mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, in the presence of plasma from DDAVP-treated mice, tumor cells remained as a single cell suspension.
    3 context sentences
    Summary · context
    The in vitro formation of multicellular aggregates in the presence of citrated plasma from control and DDAVP-treated mice was also examined.
    Summary · context
    Control plasma rapidly induced a significant tumor cell aggregation.
    Summary · context
    We have investigated the effects of desmopressin (DDAVP), a synthetic analog of the natural hormone vasopressin, on experimental lung colonization of mammary tumor cells using a syngeneic BALB/c mouse model.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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