The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction.

Tivesten A, Bollano E, Caidahl K, Kujacic V, Sun XY, Hedner T, Hjalmarson A, Bengtsson BA, Isgaard J

Endocrinology1 Jan 2000Cited by 63 (Europe PMC)

PMID10614623DOI10.1210/endo.141.1.7249PepBankPUB-10614623

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, hexarelin did not increase body weight gain, whereas GH did.
In plain wordsIn rats after a heart attack, hexarelin did not increase weight gain, but growth hormone did.
Peptide
Hexarelin
Outcome
No significant changeBody weight gain
Study
ratn: not reported in source
rats after left coronary artery ligation (myocardial infarction)
Comparator
0.9% NaCl
Outcome group
Body weight · Metabolic and weight
Studied dose
10 or 100 microg/kg x day · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
GH, but not Hex, increased body weight gain.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after ligation of the left coronary artery male rats were treated sc twice daily with hexarelin [10 microg/kg x day (Hex10) or 100 microg/kg x day (Hex100)], recombinant human GH (2.5 mg/kg x day), or 0.9% NaCl for 2 weeks.
Report a problemFND-1061462301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, hexarelin 100 microg/kg x day decreased total peripheral resistance versus NaCl.
In plain wordsIn rats after a heart attack, the higher hexarelin dose lowered peripheral resistance compared with saline.
Peptide
Hexarelin
Outcome
DecreaseTotal peripheral resistance
Study
ratn: not reported in source
rats after left coronary artery ligation (myocardial infarction)
Comparator
0.9% NaCl
Outcome group
Heart function · Cardiovascular
Studied dose
100 microg/kg x day · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
GH and Hex100 decreased total peripheral resistance (P < 0.05) and increased stroke volume (P < 0.05 and P < 0.01, respectively) and stroke volume index (P = 0.06 and P < 0.01, respectively) vs. NaCl.
2 context sentences(design, population, supporting numbers)
Summary · context
vs. NaCl.
Summary · context
Four weeks after ligation of the left coronary artery male rats were treated sc twice daily with hexarelin [10 microg/kg x day (Hex10) or 100 microg/kg x day (Hex100)], recombinant human GH (2.5 mg/kg x day), or 0.9% NaCl for 2 weeks.
Report a problemFND-1061462302
03AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, hexarelin 100 microg/kg x day increased stroke volume versus NaCl.
In plain wordsIn rats after a heart attack, the higher hexarelin dose raised stroke volume compared with saline.
Peptide
Hexarelin
Outcome
IncreaseStroke volume
Study
ratn: not reported in source
rats after left coronary artery ligation (myocardial infarction)
Comparator
0.9% NaCl
Outcome group
Heart function · Cardiovascular
Studied dose
100 microg/kg x day · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
GH and Hex100 decreased total peripheral resistance (P < 0.05) and increased stroke volume (P < 0.05 and P < 0.01, respectively) and stroke volume index (P = 0.06 and P < 0.01, respectively) vs. NaCl.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after ligation of the left coronary artery male rats were treated sc twice daily with hexarelin [10 microg/kg x day (Hex10) or 100 microg/kg x day (Hex100)], recombinant human GH (2.5 mg/kg x day), or 0.9% NaCl for 2 weeks.
Report a problemFND-1061462303
04AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, hexarelin 100 microg/kg x day increased stroke volume index versus NaCl.
In plain wordsIn rats after a heart attack, the higher hexarelin dose raised stroke volume index compared with saline.
Peptide
Hexarelin
Outcome
IncreaseStroke volume index
Study
ratn: not reported in source
rats after left coronary artery ligation (myocardial infarction)
Comparator
0.9% NaCl
Outcome group
Heart function · Cardiovascular
Studied dose
100 microg/kg x day · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
GH and Hex100 decreased total peripheral resistance (P < 0.05) and increased stroke volume (P < 0.05 and P < 0.01, respectively) and stroke volume index (P = 0.06 and P < 0.01, respectively) vs. NaCl.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after ligation of the left coronary artery male rats were treated sc twice daily with hexarelin [10 microg/kg x day (Hex10) or 100 microg/kg x day (Hex100)], recombinant human GH (2.5 mg/kg x day), or 0.9% NaCl for 2 weeks.
Report a problemFND-1061462304
05AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, hexarelin 100 microg/kg x day increased cardiac output versus NaCl.
In plain wordsIn rats after a heart attack, the higher hexarelin dose raised cardiac output compared with saline.
Peptide
Hexarelin
Outcome
IncreaseCardiac output
Study
ratn: not reported in source
rats after left coronary artery ligation (myocardial infarction)
Comparator
0.9% NaCl
Outcome group
Heart function · Cardiovascular
Studied dose
100 microg/kg x day · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
Cardiac output was increased by GH and Hex100 (P < 0.05), and cardiac index was increased by Hex100 with a borderline significance for GH (P = 0.06).
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after ligation of the left coronary artery male rats were treated sc twice daily with hexarelin [10 microg/kg x day (Hex10) or 100 microg/kg x day (Hex100)], recombinant human GH (2.5 mg/kg x day), or 0.9% NaCl for 2 weeks.
Report a problemFND-1061462305
06AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, hexarelin 100 microg/kg x day increased cardiac index versus NaCl.
In plain wordsIn rats after a heart attack, the higher hexarelin dose raised cardiac index compared with saline.
Peptide
Hexarelin
Outcome
IncreaseCardiac index
Study
ratn: not reported in source
rats after left coronary artery ligation (myocardial infarction)
Comparator
0.9% NaCl
Outcome group
Heart function · Cardiovascular
Studied dose
100 microg/kg x day · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
Cardiac output was increased by GH and Hex100 (P < 0.05), and cardiac index was increased by Hex100 with a borderline significance for GH (P = 0.06).
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after ligation of the left coronary artery male rats were treated sc twice daily with hexarelin [10 microg/kg x day (Hex10) or 100 microg/kg x day (Hex100)], recombinant human GH (2.5 mg/kg x day), or 0.9% NaCl for 2 weeks.
Report a problemFND-1061462306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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