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Study · Ex vivo tissue · rat · 1999

7 results

[Effect of thymus polypeptide fractions on the development of rat thymus and spleen in organ culture].

Chalisova NI, Khavinson VKh, Penniiaĭnen VA, Grigor'ev EI

Tsitologiia1 Jan 1999

PMID10591126 (opens in a new tab)PepBankPUB-10591126
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In thymus explants from 21-day-old rats, thymalin stimulated tissue development compared with control explants.

    In plain wordsIn lab tests with young rat thymus tissue, thymalin stimulated tissue development compared with control tissue.

    Peptide
    Thymalin
    Outcome
    IncreaseThymus tissue development
    Study

    ratn: not reported in source

    organotypic thymus and spleen explants
    Comparator
    control explants
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Vilon, thymogen and thymalin in concentrations of 2 and 10 ng/ml and 5 ng/ml, resp., exerted stimulating effects in thymus and spleen tissue cultures from 21-day old rats as compared to the control explants.
    1 context sentence
    Summary · context
    Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats.
  2. 02LabEx vivo tissueEfficacy outcome

    In spleen explants from 21-day-old rats, thymalin stimulated tissue development compared with control explants.

    In plain wordsIn lab tests with young rat spleen tissue, thymalin stimulated tissue development compared with control tissue.

    Peptide
    Thymalin
    Outcome
    IncreaseSpleen tissue development
    Study

    ratn: not reported in source

    organotypic thymus and spleen explants
    Comparator
    control explants
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Vilon, thymogen and thymalin in concentrations of 2 and 10 ng/ml and 5 ng/ml, resp., exerted stimulating effects in thymus and spleen tissue cultures from 21-day old rats as compared to the control explants.
    1 context sentence
    Summary · context
    Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats.
  3. 03LabEx vivo tissueActivity measurement

    In thymus explants from 21-day-old rats, thymogen stimulated tissue development compared with control explants.

    In plain wordsIn lab tests, thymogen stimulated thymus tissue from 21-day-old rats compared with control tissue.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseThymus tissue culture development at 21 days of age
    Study

    ratn: not reported in source

    Organotypic thymus and spleen explants
    Comparator
    Control explants
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Vilon, thymogen and thymalin in concentrations of 2 and 10 ng/ml and 5 ng/ml, resp., exerted stimulating effects in thymus and spleen tissue cultures from 21-day old rats as compared to the control explants.
    1 context sentence
    Summary · context
    Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats.
  4. 04LabEx vivo tissueActivity measurement

    In spleen explants from 21-day-old rats, thymogen stimulated tissue development compared with control explants.

    In plain wordsIn lab tests, thymogen stimulated spleen tissue from 21-day-old rats compared with control tissue.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseSpleen tissue culture development at 21 days of age
    Study

    ratn: not reported in source

    Organotypic thymus and spleen explants
    Comparator
    Control explants
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Vilon, thymogen and thymalin in concentrations of 2 and 10 ng/ml and 5 ng/ml, resp., exerted stimulating effects in thymus and spleen tissue cultures from 21-day old rats as compared to the control explants.
    1 context sentence
    Summary · context
    Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats.
  5. 05LabEx vivo tissueActivity measurement

    In thymus explants from 1-day-old rats, thymogen inhibited tissue development compared with control explants.

    In plain wordsIn lab tests, thymogen inhibited thymus tissue from 1-day-old rats compared with control tissue.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseThymus tissue culture development at 1 day of age
    Study

    ratn: not reported in source

    Organotypic thymus and spleen explants
    Comparator
    Control explants
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon and thymogen showed inhibiting effect in the thymus tissue cultures from 1-day old rats as compared to the control explants.
    1 context sentence
    Summary · context
    Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats.
  6. 06LabEx vivo tissueActivity measurement

    In rat organ cultures, peptides including thymogen with concanavalin A decreased the action of concanavalin A alone.

    In plain wordsIn lab tests, peptides including thymogen reduced concanavalin A action compared with concanavalin A alone.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseConcanavalin A action in organ culture
    Study

    ratn: not reported in source

    Organotypic thymus and spleen explants
    Comparator
    Concanavalin A alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the peptides together with concanavalin A in concentration of 10 mkg/ml resulted in decreasing the action of concanavalin A alone.
    1 context sentence
    Summary · context
    Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats.

Studies that did not test the peptide alone1

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

  1. 07LabNot a test of Thymalin aloneEx vivo tissueActivity measurement

    In rat organ cultures, peptides including thymalin with concanavalin A decreased concanavalin A action compared with concanavalin A alone.

    In plain wordsIn lab tests with rat tissue, peptides including thymalin with concanavalin A reduced its action compared with concanavalin A alone.

    Peptide
    Thymalin
    Outcome
    DecreaseConcanavalin A action
    Study

    ratn: not reported in source

    organotypic thymus and spleen explants
    Comparator
    concanavalin A alone
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    However, the peptides together with concanavalin A in concentration of 10 mkg/ml resulted in decreasing the action of concanavalin A alone.
    1 context sentence
    Summary · context
    Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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