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Study · Animal study (in vivo) · mouse · 1999

3 results

Preparation, purification, and characterization of a reversibly lipidized desmopressin with potentiated anti-diuretic activity.

Wang J, Shen D, Shen WC

Pharmaceutical research1 Nov 1999Cited by 35 (Europe PMC)

PMID10571271 (opens in a new tab)DOI10.1023/a:1018929312715 (opens in a new tab)PepBankPUB-10571271
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In mice, intravenously injected DDAVP declined rapidly during the first 20 min, followed by slow elimination.

    In plain wordsIn mice, injected desmopressin declined rapidly during the first 20 min, followed by slow elimination.

    Peptide
    Desmopressin
    Outcome
    DecreasePlasma concentration time course
    Study

    mousen: not reported in source

    CF-1 mice
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    The plasma concentration of intravenously injected DDAVP in mice decreased rapidly during the first 20 min and followed by a slow elimination rate.
    1 context sentence
    Summary · context
    Preliminary pharmacokinetic and biodistribution studies of intravenously injected DDAVP and DPP were carried out in CF-1 mice.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In mice, native DDAVP had shorter liver retention than DPP.

    In plain wordsIn mice, native desmopressin stayed in the liver for less time than DPP.

    Peptide
    Desmopressin
    Outcome
    DecreaseLiver retention
    Study

    mousen: not reported in source

    CF-1 mice
    Comparator
    DPP
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    Studies of the organ distribution in mice indicated that the liver retention of DPP was longer than that of DDAVP.
    1 context sentence
    Summary · context
    Preliminary pharmacokinetic and biodistribution studies of intravenously injected DDAVP and DPP were carried out in CF-1 mice.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In mice, intestinal excretion of native DDAVP exceeded that of DPP significantly.

    In plain wordsIn mice, intestinal excretion of native desmopressin exceeded that of DPP.

    Peptide
    Desmopressin
    Outcome
    IncreaseIntestinal excretion
    Study

    mousen: not reported in source

    CF-1 mice
    Comparator
    DPP
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    On the other hand, the intestinal excretion of DPP was significantly less than that of DDAVP.
    1 context sentence
    Summary · context
    Preliminary pharmacokinetic and biodistribution studies of intravenously injected DDAVP and DPP were carried out in CF-1 mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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