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Study · Randomized controlled trial · n = 30 · 1999

4 results

Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study.

Bouvattier C, Coste J, Rodrigue D, Teinturier C, Carel JC, Chaussain JL, Bougnères PF

The Journal of clinical endocrinology and metabolism1 Oct 1999Cited by 73 (Europe PMC)

PMID10522998 (opens in a new tab)DOI10.1210/jcem.84.10.6032 (opens in a new tab)PepBankPUB-10522998
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In girls with advanced puberty, triptorelin transiently delayed sexual maturation compared with no treatment.

    In plain wordsIn girls with advanced puberty, triptorelin temporarily delayed sexual maturation compared with no treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSexual maturation
    Study

    n = 30

    Comparator
    No treatment
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 yrAs given in this study (human).

    Source sentences

    Summary
    Although GnRH agonists transiently delayed sexual maturation as well as bone age and growth rate, they had no clear-cut long-standing effect, and final height was comparable in treated (157.6 +/- 4.0 cm) and untreated girls (156.1 +/- 5.3 cm) (NS).
    2 context sentences
    Summary · context
    To test if a comparable effect can be obtained in older girls, we performed a long-term controlled study in 30 caucasian girls whose puberty started between 8.4 and 10 yr (9.4 +/- 0.1 yr), a variant of normal called "advanced" puberty.
    Summary · context
    They were randomized 2:1 to receive 3.75 mg triptorelin im every 4 weeks for 2 yr (n = 20, group I) or no treatment (n = 10, group II).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In girls with advanced puberty, triptorelin transiently delayed bone age progression compared with no treatment.

    In plain wordsIn girls with advanced puberty, triptorelin temporarily delayed bone maturation compared with no treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseBone age progression
    Study

    n = 30

    Comparator
    No treatment
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 yrAs given in this study (human).

    Source sentences

    Summary
    Although GnRH agonists transiently delayed sexual maturation as well as bone age and growth rate, they had no clear-cut long-standing effect, and final height was comparable in treated (157.6 +/- 4.0 cm) and untreated girls (156.1 +/- 5.3 cm) (NS).
    2 context sentences
    Summary · context
    To test if a comparable effect can be obtained in older girls, we performed a long-term controlled study in 30 caucasian girls whose puberty started between 8.4 and 10 yr (9.4 +/- 0.1 yr), a variant of normal called "advanced" puberty.
    Summary · context
    They were randomized 2:1 to receive 3.75 mg triptorelin im every 4 weeks for 2 yr (n = 20, group I) or no treatment (n = 10, group II).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In girls with advanced puberty, triptorelin transiently slowed growth compared with no treatment.

    In plain wordsIn girls with advanced puberty, triptorelin temporarily slowed growth compared with no treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseGrowth rate
    Study

    n = 30

    Comparator
    No treatment
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 yrAs given in this study (human).

    Source sentences

    Summary
    Although GnRH agonists transiently delayed sexual maturation as well as bone age and growth rate, they had no clear-cut long-standing effect, and final height was comparable in treated (157.6 +/- 4.0 cm) and untreated girls (156.1 +/- 5.3 cm) (NS).
    2 context sentences
    Summary · context
    To test if a comparable effect can be obtained in older girls, we performed a long-term controlled study in 30 caucasian girls whose puberty started between 8.4 and 10 yr (9.4 +/- 0.1 yr), a variant of normal called "advanced" puberty.
    Summary · context
    They were randomized 2:1 to receive 3.75 mg triptorelin im every 4 weeks for 2 yr (n = 20, group I) or no treatment (n = 10, group II).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In girls with advanced puberty, final height was comparable with triptorelin and no treatment.

    In plain wordsIn girls with advanced puberty, final height was similar with triptorelin and no treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFinal height
    Study

    n = 30

    Comparator
    No treatment
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 yrAs given in this study (human).

    Measurements

    Final height
    157.6 cm
    treated
    Final height
    156.1 cm
    untreated

    Source sentences

    Summary
    Although GnRH agonists transiently delayed sexual maturation as well as bone age and growth rate, they had no clear-cut long-standing effect, and final height was comparable in treated (157.6 +/- 4.0 cm) and untreated girls (156.1 +/- 5.3 cm) (NS).
    2 context sentences
    Summary · context
    To test if a comparable effect can be obtained in older girls, we performed a long-term controlled study in 30 caucasian girls whose puberty started between 8.4 and 10 yr (9.4 +/- 0.1 yr), a variant of normal called "advanced" puberty.
    Summary · context
    They were randomized 2:1 to receive 3.75 mg triptorelin im every 4 weeks for 2 yr (n = 20, group I) or no treatment (n = 10, group II).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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