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Study · Animal study (in vivo) · rat · 1999

5 results

Growth hormone and hexarelin prevent endothelial vasodilator dysfunction in aortic rings of the hypophysectomized rat.

Rossoni G, Locatelli V, De Gennaro Colonna V, Torsello A, Schweiger F, Boghen M, Nilsson M, Bernareggi M, Müller EE, Berti F

Journal of cardiovascular pharmacology1 Sept 1999Cited by 17 (Europe PMC)

PMID10471007 (opens in a new tab)DOI10.1097/00005344-199909000-00021 (opens in a new tab)PepBankPUB-10471007
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, hexarelin pretreatment antagonized the hyperresponsiveness of aortic tissue to endothelin-1.

    In plain wordsIn rats with the pituitary gland removed, hexarelin reduced the strong response of aortic tissue to endothelin-1.

    Peptide
    Hexarelin
    Outcome
    DecreaseAortic hyperresponsiveness to endothelin-1
    Study

    ratn: not reported in source

    Hypophysectomized rat, aortic rings
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    80 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment of hypophysectomized rats with GH or hexarelin markedly antagonized the hyperresponsiveness of the aortic tissue to ET-1 and allowed a consistent recovery of both the relaxant activity of ACh and the generation of 6-keto-PGF1alpha.
    1 context sentence
    Summary · context
    The endothelial vasodilation mechanism(s) has been investigated in aortic rings of hypophysectomized male rats as well as hypophysectomized rats treated for 7 days with growth hormone (GH, 400 microg/kg, s.c.) or hexarelin (80 microg/kg, s.c.).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, hexarelin pretreatment allowed a consistent recovery of the relaxant activity of acetylcholine in aortic rings.

    In plain wordsIn rats with the pituitary gland removed, hexarelin helped aortic tissue recover its ability to relax in response to acetylcholine.

    Peptide
    Hexarelin
    Outcome
    IncreaseRelaxant activity of acetylcholine in aortic rings
    Study

    ratn: not reported in source

    Hypophysectomized rat, aortic rings
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    80 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment of hypophysectomized rats with GH or hexarelin markedly antagonized the hyperresponsiveness of the aortic tissue to ET-1 and allowed a consistent recovery of both the relaxant activity of ACh and the generation of 6-keto-PGF1alpha.
    1 context sentence
    Summary · context
    The endothelial vasodilation mechanism(s) has been investigated in aortic rings of hypophysectomized male rats as well as hypophysectomized rats treated for 7 days with growth hormone (GH, 400 microg/kg, s.c.) or hexarelin (80 microg/kg, s.c.).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, hexarelin pretreatment allowed a consistent recovery of the generation of 6-keto-PGF1alpha by aortic rings.

    In plain wordsIn rats with the pituitary gland removed, hexarelin helped restore release of a prostacyclin by-product from aortic tissue.

    Peptide
    Hexarelin
    Outcome
    Increase6-keto-PGF1alpha generation by aortic rings
    Study

    ratn: not reported in source

    Hypophysectomized rat, aortic rings
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    80 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment of hypophysectomized rats with GH or hexarelin markedly antagonized the hyperresponsiveness of the aortic tissue to ET-1 and allowed a consistent recovery of both the relaxant activity of ACh and the generation of 6-keto-PGF1alpha.
    1 context sentence
    Summary · context
    The endothelial vasodilation mechanism(s) has been investigated in aortic rings of hypophysectomized male rats as well as hypophysectomized rats treated for 7 days with growth hormone (GH, 400 microg/kg, s.c.) or hexarelin (80 microg/kg, s.c.).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, hexarelin replacement did not increase body weight, unlike GH.

    In plain wordsIn rats with the pituitary gland removed, hexarelin did not raise body weight, unlike growth hormone.

    Peptide
    Hexarelin
    Outcome
    No significant changeBody weight
    Study

    ratn: not reported in source

    Hypophysectomized rat, aortic rings
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    80 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    hexarelin replacement neither increased body weight
    1 context sentence
    Summary · context
    The endothelial vasodilation mechanism(s) has been investigated in aortic rings of hypophysectomized male rats as well as hypophysectomized rats treated for 7 days with growth hormone (GH, 400 microg/kg, s.c.) or hexarelin (80 microg/kg, s.c.).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, hexarelin replacement did not affect plasma IGF-I concentrations, unlike GH.

    In plain wordsIn rats with the pituitary gland removed, hexarelin did not change blood IGF-I levels, unlike growth hormone.

    Peptide
    Hexarelin
    Outcome
    No significant changePlasma IGF-I concentration
    Study

    ratn: not reported in source

    Hypophysectomized rat, aortic rings
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    80 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    hexarelin replacement neither increased body weight nor affected the plasma concentrations of IGF-I
    1 context sentence
    Summary · context
    The endothelial vasodilation mechanism(s) has been investigated in aortic rings of hypophysectomized male rats as well as hypophysectomized rats treated for 7 days with growth hormone (GH, 400 microg/kg, s.c.) or hexarelin (80 microg/kg, s.c.).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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