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Study · Animal study (in vivo) · rat · 1999

6 results

Thymosin beta4 accelerates wound healing.

Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK

The Journal of investigative dermatology1 Sept 1999Cited by 223 (Europe PMC)

PMID10469335 (opens in a new tab)DOI10.1046/j.1523-1747.1999.00708.x (opens in a new tab)PepBankPUB-10469335
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with full thickness wounds, topical or intraperitoneal thymosin beta4 increased reepithelialization by 42% over saline controls at day 4.

    In plain wordsIn rats with skin wounds, thymosin beta4 given on the skin or by injection increased skin regrowth more than saline at day 4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseReepithelialization at day 4
    Study

    ratn: not reported in source

    full thickness wound model
    Comparator
    Saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical or intraperitonealAs given in this study (rat).

    Measurements

    Reepithelialization increase vs saline
    42%
    day 4

    Source sentences

    Summary
    Addition of Tbeta4 topically or intraperitoneally increased reepithelialization by 42% over saline controls at 4 d
    1 context sentence
    Summary · context
    In this study, we investigated whether the angiogenic thymic peptide thymosin beta4 (Tbeta4) enhanced wound healing in a rat full thickness wound model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with full thickness wounds, topical or intraperitoneal thymosin beta4 increased reepithelialization by as much as 61% over saline controls at day 7.

    In plain wordsIn rats with skin wounds, thymosin beta4 increased skin regrowth more than saline at day 7.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseReepithelialization at day 7
    Study

    ratn: not reported in source

    full thickness wound model
    Comparator
    Saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical or intraperitonealAs given in this study (rat).

    Measurements

    Reepithelialization increase vs saline
    ≤ 61%
    day 7

    Source sentences

    Summary
    Addition of Tbeta4 topically or intraperitoneally increased reepithelialization by 42% over saline controls at 4 d and by as much as 61% at 7 d post-wounding.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with full thickness wounds, thymosin beta4-treated wounds contracted at least 11% more than controls by day 7.

    In plain wordsIn rats with skin wounds, wounds treated with thymosin beta4 contracted more than control wounds by day 7.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound contraction at day 7
    Study

    ratn: not reported in source

    full thickness wound model
    Comparator
    Saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical or intraperitonealAs given in this study (rat).

    Measurements

    Contraction vs controls
    ≥ 11%
    day 7

    Source sentences

    Summary
    Treated wounds also contracted at least 11% more than controls by day 7.
    1 context sentence
    Summary · context
    In this study, we investigated whether the angiogenic thymic peptide thymosin beta4 (Tbeta4) enhanced wound healing in a rat full thickness wound model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with full thickness wounds, thymosin beta4-treated wounds showed increased collagen deposition.

    In plain wordsIn rats with skin wounds, wounds treated with thymosin beta4 showed more collagen deposition.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCollagen deposition
    Study

    ratn: not reported in source

    full thickness wound model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Increased collagen deposition and angiogenesis were observed in the treated wounds.
    1 context sentence
    Summary · context
    In this study, we investigated whether the angiogenic thymic peptide thymosin beta4 (Tbeta4) enhanced wound healing in a rat full thickness wound model.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with full thickness wounds, thymosin beta4-treated wounds showed increased angiogenesis.

    In plain wordsIn rats with skin wounds, wounds treated with thymosin beta4 showed more new blood vessel growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAngiogenesis in wounds
    Study

    ratn: not reported in source

    full thickness wound model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Increased collagen deposition and angiogenesis were observed in the treated wounds.
    1 context sentence
    Summary · context
    In this study, we investigated whether the angiogenic thymic peptide thymosin beta4 (Tbeta4) enhanced wound healing in a rat full thickness wound model.
  6. 06LabIn vitro (cells)Activity measurement

    In a Boyden chamber assay, thymosin beta4 stimulated keratinocyte migration 2-3-fold over medium alone after 4-5 h, with as little as 10 pg added.

    In plain wordsIn lab tests, thymosin beta4 made skin cells called keratinocytes migrate more than medium alone, at a very low amount.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseKeratinocyte migration in Boyden chamber
    Study

    n: not reported in source

    keratinocytes in Boyden chamber assay
    Comparator
    Medium alone
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    as little as 10 pg · 4-5 hAs given in this study.

    Measurements

    Migration vs medium alone
    2 to 3 fold
    4-5 h

    Source sentences

    Summary
    We also found that Tbeta4 stimulated keratinocyte migration in the Boyden chamber assay. After 4-5 h, migration was stimulated 2-3-fold over migration with medium alone when as little as 10 pg of Tbeta4 was added to the assay.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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