Skip to content

Study · Animal study (in vivo) · rat · 1999

4 results

LH down-regulates gonadotropin-releasing hormone (GnRH) receptor, but not GnRH, mRNA levels in the rat testis.

Botté MC, Lerrant Y, Lozach A, Bérault A, Counis R, Kottler ML

The Journal of endocrinology1 Sept 1999Cited by 11 (Europe PMC)

PMID10467232 (opens in a new tab)DOI10.1677/joe.0.1620409 (opens in a new tab)PepBankPUB-10467232
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin reduced testicular GnRH mRNA after injection compared with control.

    In plain wordsIn rats, triptorelin reduced testicular GnRH genetic messages compared with control.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseTesticular GnRH mRNA
    Study

    ratn: not reported in source

    rat testis
    Comparator
    Control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GnRH mRNA
    ≈ 38 % of control
    24 h after injection

    Source sentences

    Summary
    We observed an acute reduction of both GnRH and GnRH-R mRNAs 24 h after the injection (about 38% of control).
    2 context sentences
    Summary · context
    To assess this hypothesis, we investigated the effects of GnRH analogs, gonadotropins and testosterone on the levels of both GnRH and GnRH-R mRNA in the rat testis.
    Summary · context
    Using dot blot hybridization, we measured the mRNA levels 2 to 120 h after the administration of the GnRH agonist, triptorelin.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin reduced testicular GnRH receptor mRNA after injection compared with control.

    In plain wordsIn rats, triptorelin reduced testicular GnRH receptor genetic messages compared with control.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseTesticular GnRH receptor mRNA
    Study

    ratn: not reported in source

    rat testis
    Comparator
    Control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GnRH-R mRNA
    ≈ 38 % of control
    24 h after injection

    Source sentences

    Summary
    We observed an acute reduction of both GnRH and GnRH-R mRNAs 24 h after the injection (about 38% of control).
    2 context sentences
    Summary · context
    To assess this hypothesis, we investigated the effects of GnRH analogs, gonadotropins and testosterone on the levels of both GnRH and GnRH-R mRNA in the rat testis.
    Summary · context
    Using dot blot hybridization, we measured the mRNA levels 2 to 120 h after the administration of the GnRH agonist, triptorelin.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats given triptorelin, serum LH initially peaked and then declined.

    In plain wordsIn rats given triptorelin, blood LH first peaked and then declined.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedSerum LH time course
    Study

    ratn: not reported in source

    rat testis
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Initially, the concentrations of serum LH and FSH peaked, then declined, probably due to the desensitization of the gonadotrope cells.
    2 context sentences
    Summary · context
    To assess this hypothesis, we investigated the effects of GnRH analogs, gonadotropins and testosterone on the levels of both GnRH and GnRH-R mRNA in the rat testis.
    Summary · context
    Using dot blot hybridization, we measured the mRNA levels 2 to 120 h after the administration of the GnRH agonist, triptorelin.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats given triptorelin, serum FSH initially peaked and then declined.

    In plain wordsIn rats given triptorelin, blood FSH first peaked and then declined.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedSerum FSH time course
    Study

    ratn: not reported in source

    rat testis
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Initially, the concentrations of serum LH and FSH peaked, then declined, probably due to the desensitization of the gonadotrope cells.
    2 context sentences
    Summary · context
    To assess this hypothesis, we investigated the effects of GnRH analogs, gonadotropins and testosterone on the levels of both GnRH and GnRH-R mRNA in the rat testis.
    Summary · context
    Using dot blot hybridization, we measured the mRNA levels 2 to 120 h after the administration of the GnRH agonist, triptorelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.