The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants.

Korbonits M, Little JA, Forsling ML, Tringali G, Costa A, Navarra P, Trainer PJ, Grossman AB

Journal of neuroendocrinology1 Jul 1999Cited by 48 (Europe PMC)

PMID10444309DOI10.1046/j.1365-2826.1999.00353.xPepBankPUB-10444309

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, GHRP‑6 at low concentrations did not change basal or potassium-stimulated GHRH release.
In plain wordsIn rat brain tissue in a dish, low doses of GHRP‑6 did not change release of GHRH.
Peptide
GHRP-6
Outcome
No significant changeBasal and potassium-stimulated GHRH release at low concentrations
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
There was no significant change in either the basal or potassium-stimulated release of GHRH or SS at low concentrations of any of the secretagogues
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430901
02LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, GHRP‑6 at low concentrations did not change basal or potassium-stimulated somatostatin release.
In plain wordsIn rat brain tissue in a dish, low doses of GHRP‑6 did not change release of somatostatin.
Peptide
GHRP-6
Outcome
No significant changeBasal and potassium-stimulated somatostatin release at low concentrations
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
There was no significant change in either the basal or potassium-stimulated release of GHRH or SS at low concentrations of any of the secretagogues
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430902
03LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, GHRP‑6 at millimolar doses paradoxically inhibited GHRH release.
In plain wordsIn rat brain tissue in a dish, very high doses of GHRP‑6 reduced release of GHRH.
Peptide
GHRP-6
Outcome
DecreaseGHRH release at millimolar doses
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
millimolarAs given in this study (rat).
Measurements
GHRH release ratio to preceding basal release at 20 min
0.55 ratio
GHRP-6
GHRH release ratio to preceding basal release at 20 min
0.97 ratio
control
Source sentences
Summary
at millimolar doses a paradoxical inhibition of GHRH was observed with GHRP-6, hexarelin and L-692 585
2 context sentences(design, population, supporting numbers)
Summary · context
at 20 min control group: 0.97+/-0.02, GHRP-6: 0.55+/-0.04, P<0.001 compared to control group
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430903
04LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, GHRP‑6 stimulated hypothalamic AVP release.
In plain wordsIn rat brain tissue in a dish, GHRP‑6 increased release of vasopressin.
Peptide
GHRP-6
Outcome
IncreaseVasopressin (AVP) release
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
10-4 MAs given in this study (rat).
Source sentences
Summary
GHSs stimulated hypothalamic AVP release (at 20 min control: 0. 99+/-0.06 ratio to basal release, 10-4 M concentration of GHRP-6: 6. 31+/-1, P<0.001, hexarelin: 1.88+/-0.4, P<0.01, L-692,429: 1.90+/-0. 5, P<0.05 and L-692,585: 2.34+/-0.96, P<0.01), while no stimulatory effect was found on CRH release.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430904
05LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, GHRP‑6 had no stimulatory effect on CRH release.
In plain wordsIn rat brain tissue in a dish, GHRP‑6 did not increase release of CRH.
Peptide
GHRP-6
Outcome
No significant changeCRH release
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
GHSs stimulated hypothalamic AVP release (at 20 min control: 0. 99+/-0.06 ratio to basal release, 10-4 M concentration of GHRP-6: 6. 31+/-1, P<0.001, hexarelin: 1.88+/-0.4, P<0.01, L-692,429: 1.90+/-0. 5, P<0.05 and L-692,585: 2.34+/-0.96, P<0.01), while no stimulatory effect was found on CRH release.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430905
06LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, hexarelin at low concentrations did not change basal or potassium-stimulated GHRH release.
In plain wordsIn rat brain tissue in a dish, low doses of hexarelin did not change release of GHRH.
Peptide
Hexarelin
Outcome
No significant changeBasal and potassium-stimulated GHRH release at low concentrations
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
There was no significant change in either the basal or potassium-stimulated release of GHRH or SS at low concentrations of any of the secretagogues
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430906
07LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, hexarelin at low concentrations did not change basal or potassium-stimulated somatostatin release.
In plain wordsIn rat brain tissue in a dish, low doses of hexarelin did not change release of somatostatin.
Peptide
Hexarelin
Outcome
No significant changeBasal and potassium-stimulated somatostatin release at low concentrations
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
There was no significant change in either the basal or potassium-stimulated release of GHRH or SS at low concentrations of any of the secretagogues
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430907
08LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, hexarelin at millimolar doses paradoxically inhibited GHRH release.
In plain wordsIn rat brain tissue in a dish, very high doses of hexarelin reduced release of GHRH.
Peptide
Hexarelin
Outcome
DecreaseGHRH release at millimolar doses
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
millimolarAs given in this study (rat).
Source sentences
Summary
at millimolar doses a paradoxical inhibition of GHRH was observed with GHRP-6, hexarelin and L-692 585
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430908
09LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, hexarelin stimulated somatostatin release after 60 or 80 min.
In plain wordsIn rat brain tissue in a dish, hexarelin increased release of somatostatin after an hour or more.
Peptide
Hexarelin
Outcome
IncreaseSomatostatin release after 60 or 80 min
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Somatostatin release ratio to preceding basal release at 80 min
1.23 ratio
hexarelin
Somatostatin release ratio to preceding basal release at 80 min
0.8 ratio
control
Source sentences
Summary
while SS was stimulated after 60 or 80 min (at 80 min control: 0.80+/-0.03, hexarelin: 1.23+/-0.07, P<0.05
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430909
10LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, hexarelin stimulated hypothalamic AVP release.
In plain wordsIn rat brain tissue in a dish, hexarelin increased release of vasopressin.
Peptide
Hexarelin
Outcome
IncreaseVasopressin (AVP) release
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Measurements
AVP release ratio to basal release
1.88 ratio
hexarelin
Source sentences
Summary
GHSs stimulated hypothalamic AVP release (at 20 min control: 0. 99+/-0.06 ratio to basal release, 10-4 M concentration of GHRP-6: 6. 31+/-1, P<0.001, hexarelin: 1.88+/-0.4, P<0.01, L-692,429: 1.90+/-0. 5, P<0.05 and L-692,585: 2.34+/-0.96, P<0.01), while no stimulatory effect was found on CRH release.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430910
11LabEx vivo tissueActivity measurement
In acute rat hypothalamic explants, hexarelin had no stimulatory effect on CRH release.
In plain wordsIn rat brain tissue in a dish, hexarelin did not increase release of CRH.
Peptide
Hexarelin
Outcome
No significant changeCRH release
Study
ratn: not reported in source
acute hypothalamic explants
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
GHSs stimulated hypothalamic AVP release (at 20 min control: 0. 99+/-0.06 ratio to basal release, 10-4 M concentration of GHRP-6: 6. 31+/-1, P<0.001, hexarelin: 1.88+/-0.4, P<0.01, L-692,429: 1.90+/-0. 5, P<0.05 and L-692,585: 2.34+/-0.96, P<0.01), while no stimulatory effect was found on CRH release.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have therefore investigated the direct effect of several GHSs (GHRP-6, hexarelin and the non-peptide analogues L-692, 429 and L-692, 585) on GHRH, somatostatin (SS), corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro in an acute rat hypoth…
Report a problemFND-1044430911

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 2
13 Oct 2026, 16:31 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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