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Study · In vitro (cells) · 1999

7 results

Expression of functional growth hormone secretagogue receptors in human pituitary adenomas: polymerase chain reaction, triple in-situ hybridization and cell culture studies.

Barlier A, Zamora AJ, Grino M, Gunz G, Pellegrini-Bouiller I, Morange-Ramos I, Figarella-Branger D, Dufour H, Jaquet P, Enjalbert A

Journal of neuroendocrinology1 Jul 1999Cited by 34 (Europe PMC)

PMID10444306 (opens in a new tab)DOI10.1046/j.1365-2826.1999.00351.x (opens in a new tab)PepBankPUB-10444306
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured human somatotroph and mammosomatotroph adenoma cells, MK-0677 stimulated GH release dose-dependently, with maximal effect at 6 h.

    In plain wordsIn cells from human pituitary tumors, MK-0677 increased growth hormone release as dose increased.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseGH release
    Study

    Humann = 8

    Cultured somatotroph and mammosomatotroph adenoma cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In cultured cells from six somatotroph and two mammosomatotroph adenomas, the powerful GHS MK-0677 stimulated GH release in a dose-dependent manner, with maximal effect at 6 h.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured human adenoma cells, MK-0677 stimulated GH release in six somatotroph and two mammosomatotroph adenomas, versus three and two with GHRH.

    In plain wordsIn cells from human pituitary tumors, MK-0677 stimulated growth hormone release in more somatotroph adenomas than GHRH.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseAdenomas with stimulated GH release versus GHRH
    Study

    Humann = 8

    Cultured somatotroph and mammosomatotroph adenoma cells
    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In cultured cells from six somatotroph and two mammosomatotroph adenomas, the powerful GHS MK-0677 stimulated GH release in a dose-dependent manner, with maximal effect at 6 h.
    1 context sentence
    Summary · context
    Contrarily, when GHRH was applied, only three somatotrophs and two mamosomatotrophs were stimulated.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human mammosomatotroph adenoma cells, the PRL response to MK-0677 resembled its GH response.

    In plain wordsIn cells from human pituitary tumors, MK-0677 stimulated prolactin release similarly to growth hormone release.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreasePRL release in mammosomatotrophs
    Study

    Humann = 2

    Cultured mammosomatotroph adenoma cells
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the two mammosomatotrophs, the PRL response to MK-0677 and to GHRH was similar to the GH response.
    1 context sentence
    Summary · context
    In cultured cells from six somatotroph and two mammosomatotroph adenomas, the powerful GHS MK-0677 stimulated GH release in a dose-dependent manner, with maximal effect at 6 h.
  4. 04LabIn vitro (cells)Mechanism

    In cultured human pituitary adenoma cells, GHS-R showed homologous desensitization 24 h after an initial agonist dose.

    In plain wordsIn cells from human pituitary tumors, the secretagogue receptor became less responsive after its first stimulation.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    DecreaseHomologous receptor desensitization
    Study

    Humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An homologous desensitization of the GHS-R and the GHRH receptor was observed 24 h after a first stimulation by a single dose of the corresponding agonist.
    1 context sentence
    Summary · context
    In cultured cells from six somatotroph and two mammosomatotroph adenomas, the powerful GHS MK-0677 stimulated GH release in a dose-dependent manner, with maximal effect at 6 h.
  5. 05LabIn vitro (cells)Mechanism

    In cultured human pituitary adenoma cells, heterologous desensitization between GHS-R and GHRH receptors was not observed.

    In plain wordsIn cells from human pituitary tumors, stimulation of one receptor did not desensitize the other receptor.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeHeterologous receptor desensitization
    Study

    Humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Heterologous desensitization was not observed.
    2 context sentences
    Summary · context
    An homologous desensitization of the GHS-R and the GHRH receptor was observed 24 h after a first stimulation by a single dose of the corresponding agonist.
    Summary · context
    In cultured cells from six somatotroph and two mammosomatotroph adenomas, the powerful GHS MK-0677 stimulated GH release in a dose-dependent manner, with maximal effect at 6 h.
  6. 06LabIn vitro (cells)Efficacy outcome

    In cultured human lactotroph adenoma cells, MK-0677 stimulated hormone release dose-dependently in all tested adenomas.

    In plain wordsIn cells from human lactotroph tumors, MK-0677 increased hormone release as dose increased.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseHormone release in lactotroph adenomas
    Study

    Humann: not reported in source

    Cultured lactotroph adenoma cells
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, MK-0677 also stimulated, in a dose-dependent way, the hormone release of cells from all tested lactotroph and corticotroph adenomas.
  7. 07LabIn vitro (cells)Efficacy outcome

    In cultured human corticotroph adenoma cells, MK-0677 stimulated hormone release dose-dependently in all tested adenomas.

    In plain wordsIn cells from human corticotroph tumors, MK-0677 increased hormone release as dose increased.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseHormone release in corticotroph adenomas
    Study

    Humann: not reported in source

    Cultured corticotroph adenoma cells
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, MK-0677 also stimulated, in a dose-dependent way, the hormone release of cells from all tested lactotroph and corticotroph adenomas.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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