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Study · Non-randomized trial · n = 20 · 1999

6 results

Desmopressin in the treatment of nocturnal polyuria in the male.

Cannon A, Carter PG, McConnell AA, Abrams P

BJU international1 Jul 1999Cited by 41 (Europe PMC)

PMID10444118 (opens in a new tab)DOI10.1046/j.1464-410x.1999.00125.x (opens in a new tab)PepBankPUB-10444118
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In elderly men with nocturnal polyuria, desmopressin significantly reduced nocturnal urine volume.

    In plain wordsIn elderly men with nocturnal polyuria, desmopressin reduced night-time urine volume.

    Peptide
    Desmopressin
    Outcome
    DecreaseNocturnal urine volume
    Study

    n = 20

    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    20 microg and 40 microg · intranasal · 2-week treatment periodsAs given in this study (human).

    Source sentences

    Summary
    Desmopressin caused a significant reduction in nocturnal urine volume and the percentage of urine passed at night, but the reduction in nocturnal frequency was only significant during treatment with 40 microg desmopressin.
    2 context sentences
    Summary · context
    Twenty men (age 52-80 years) complaining of nocturia were found to have nocturnal polyuria, determined from frequency-volume charts and defined as the production of >33% of the 24 h urine volume overnight, averaged over a 1-week period.
    Summary · context
    In a double-blind study of cross-over design, a 1-week placebo run-in period was followed by two 2-week periods of placebo or 20 microg intranasal desmopressin, and ended with an open 2-week treatment period with 40 microg desmopressin.
  2. 02HumanNon-randomized trialEfficacy outcome

    In elderly men with nocturnal polyuria, desmopressin significantly reduced the percentage of urine passed at night.

    In plain wordsIn elderly men, desmopressin reduced the proportion of urine passed at night.

    Peptide
    Desmopressin
    Outcome
    DecreasePercentage of urine passed at night
    Study

    n = 20

    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    20 microg and 40 microg · intranasal · 2-week treatment periodsAs given in this study (human).

    Source sentences

    Summary
    Desmopressin caused a significant reduction in nocturnal urine volume and the percentage of urine passed at night, but the reduction in nocturnal frequency was only significant during treatment with 40 microg desmopressin.
    2 context sentences
    Summary · context
    Twenty men (age 52-80 years) complaining of nocturia were found to have nocturnal polyuria, determined from frequency-volume charts and defined as the production of >33% of the 24 h urine volume overnight, averaged over a 1-week period.
    Summary · context
    In a double-blind study of cross-over design, a 1-week placebo run-in period was followed by two 2-week periods of placebo or 20 microg intranasal desmopressin, and ended with an open 2-week treatment period with 40 microg desmopressin.
  3. 03HumanNon-randomized trialEfficacy outcome

    In elderly men, nocturnal frequency decreased significantly only with 40 microg desmopressin.

    In plain wordsIn elderly men, night-time urination decreased significantly only with 40 microg desmopressin.

    Peptide
    Desmopressin
    Outcome
    DecreaseNocturnal frequency
    Study

    n = 20

    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    40 microg · intranasal · 2 weeksAs given in this study (human).

    Source sentences

    Summary
    Desmopressin caused a significant reduction in nocturnal urine volume and the percentage of urine passed at night, but the reduction in nocturnal frequency was only significant during treatment with 40 microg desmopressin.
    2 context sentences
    Summary · context
    Twenty men (age 52-80 years) complaining of nocturia were found to have nocturnal polyuria, determined from frequency-volume charts and defined as the production of >33% of the 24 h urine volume overnight, averaged over a 1-week period.
    Summary · context
    In a double-blind study of cross-over design, a 1-week placebo run-in period was followed by two 2-week periods of placebo or 20 microg intranasal desmopressin, and ended with an open 2-week treatment period with 40 microg desmopressin.
  4. 04HumanNon-randomized trialSafety outcome

    Four elderly men experienced side effects on desmopressin.

    In plain wordsFour elderly men experienced side effects on desmopressin.

    Peptide
    Desmopressin
    Outcome
    Not applicableSide effects
    Study

    n = 20

    Outcome group
    Adverse events · Whole body
    Studied dose
    20 microg and 40 microg · intranasal · 2-week treatment periodsAs given in this study (human).

    Measurements

    Patients with side-effects
    4 patients
    on desmopressin

    Source sentences

    Summary
    Four patients on desmopressin experienced side-effects, three of which were thought to be due to fluid retention.
    2 context sentences
    Summary · context
    Twenty men (age 52-80 years) complaining of nocturia were found to have nocturnal polyuria, determined from frequency-volume charts and defined as the production of >33% of the 24 h urine volume overnight, averaged over a 1-week period.
    Summary · context
    In a double-blind study of cross-over design, a 1-week placebo run-in period was followed by two 2-week periods of placebo or 20 microg intranasal desmopressin, and ended with an open 2-week treatment period with 40 microg desmopressin.
  5. 05HumanNon-randomized trialSafety outcome

    In elderly men on desmopressin, three side effects were thought to reflect fluid retention.

    In plain wordsIn elderly men on desmopressin, three side effects were thought to reflect fluid retention.

    Peptide
    Desmopressin
    Outcome
    Not applicableSuspected fluid retention
    Study

    n = 20

    Outcome group
    Adverse events · Kidney and urinary
    Studied dose
    20 microg and 40 microg · intranasal · 2-week treatment periodsAs given in this study (human).

    Measurements

    Side-effects thought due to fluid retention
    3 patients
    of four patients with side-effects on desmopressin

    Source sentences

    Summary
    Four patients on desmopressin experienced side-effects, three of which were thought to be due to fluid retention.
    2 context sentences
    Summary · context
    Twenty men (age 52-80 years) complaining of nocturia were found to have nocturnal polyuria, determined from frequency-volume charts and defined as the production of >33% of the 24 h urine volume overnight, averaged over a 1-week period.
    Summary · context
    In a double-blind study of cross-over design, a 1-week placebo run-in period was followed by two 2-week periods of placebo or 20 microg intranasal desmopressin, and ended with an open 2-week treatment period with 40 microg desmopressin.
  6. 06HumanNon-randomized trialEfficacy outcome

    In men with nocturnal polyuria, nocturnal frequency did not decrease significantly during treatment with 20 microg intranasal desmopressin.

    In plain wordsIn men with nocturnal polyuria, night-time urination did not decrease significantly with 20 microg desmopressin.

    Peptide
    Desmopressin
    Outcome
    No significant changeNocturnal frequency at 20 microg
    Study

    n = 20

    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    20 microg · intranasal · 2 weeksAs given in this study (human).

    Source sentences

    Summary
    Desmopressin caused a significant reduction in nocturnal urine volume and the percentage of urine passed at night, but the reduction in nocturnal frequency was only significant during treatment with 40 microg desmopressin.
    2 context sentences
    Summary · context
    Twenty men (age 52-80 years) complaining of nocturia were found to have nocturnal polyuria, determined from frequency-volume charts and defined as the production of >33% of the 24 h urine volume overnight, averaged over a 1-week period.
    Summary · context
    In a double-blind study of cross-over design, a 1-week placebo run-in period was followed by two 2-week periods of placebo or 20 microg intranasal desmopressin, and ended with an open 2-week treatment period with 40 microg desmopressin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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