The effect of ovariectomy and oestrogen replacement on small artery biomechanics in the rat.

Acs N, Székács B, Nádasy GL, Várbíró S, Kakucs R, Monos E

British journal of obstetrics and gynaecology1 Feb 1999Cited by 22 (Europe PMC)

PMID10426681DOI10.1111/j.1471-0528.1999.tb08215.xPepBankPUB-10426681

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats, triptorelin-induced pharmacological ovariectomy decreased passive artery diameter versus controls.
In plain wordsIn rats, triptorelin-induced ovarian suppression decreased passive artery diameter versus controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePassive artery diameter after pharmacological ovariectomy
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Comparator
Vehicle controls
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Pharmacological ovariectomy decreased the passive diameter of the arteries and oestrogen replacement therapy prevented this.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668101
02AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats with triptorelin-induced ovarian suppression, oestrogen replacement prevented the passive artery diameter reduction.
In plain wordsIn rats with triptorelin-induced ovarian suppression, oestrogen prevented artery narrowing compared with no oestrogen replacement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOestrogen prevention of passive diameter reduction
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Comparator
Pharmacological ovariectomy without oestradiol
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Pharmacological ovariectomy decreased the passive diameter of the arteries and oestrogen replacement therapy prevented this.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668102
03AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats with triptorelin-induced ovarian suppression, oestrogen restored decreased norepinephrine reactivity.
In plain wordsIn rats with triptorelin-induced ovarian suppression, oestrogen restored norepinephrine reactivity compared with no oestrogen replacement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseNorepinephrine reactivity rescue
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Comparator
Pharmacological ovariectomy without oestradiol
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Decreased reactivity to norepinephrine was also restored by oestrogen treatment.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668103
04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats, triptorelin-induced ovarian suppression significantly decreased pressure-induced myogenic tone versus controls.
In plain wordsIn rats, triptorelin-induced ovarian suppression lowered pressure-induced artery tone versus controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseMyogenic tone after ovarian suppression
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Comparator
Vehicle controls
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Pressure induced myogenic tone was decreased significantly by oophorectomy and increased after oestradiol treatment.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668104
05AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats with triptorelin-induced ovarian suppression, oestradiol increased pressure-induced myogenic tone.
In plain wordsIn rats with triptorelin-induced ovarian suppression, oestradiol increased pressure-induced artery tone compared with no oestradiol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseMyogenic tone after oestradiol
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Comparator
Pharmacological ovariectomy without oestradiol
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Pressure induced myogenic tone was decreased significantly by oophorectomy and increased after oestradiol treatment.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668105
06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats in the triptorelin-induced ovarian suppression experiment, artery wall thickness did not change significantly.
In plain wordsIn rats in the triptorelin-induced ovarian suppression experiment, artery wall thickness did not change significantly.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeWall thickness
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
No significant changes were found in wall thickness, distensibility, elastic modulus or tangential stress.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668106
07AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats in the triptorelin-induced ovarian suppression experiment, artery distensibility did not change significantly.
In plain wordsIn rats in the triptorelin-induced ovarian suppression experiment, artery stretchability did not change significantly.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeDistensibility
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
No significant changes were found in wall thickness, distensibility, elastic modulus or tangential stress.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668107
08AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats in the triptorelin-induced ovarian suppression experiment, artery elastic modulus did not change significantly.
In plain wordsIn rats in the triptorelin-induced ovarian suppression experiment, artery stiffness did not change significantly.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeElastic modulus
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
No significant changes were found in wall thickness, distensibility, elastic modulus or tangential stress.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668108
09AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats in the triptorelin-induced ovarian suppression experiment, artery tangential stress did not change significantly.
In plain wordsIn rats in the triptorelin-induced ovarian suppression experiment, artery tangential stress did not change significantly.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeTangential stress
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
No significant changes were found in wall thickness, distensibility, elastic modulus or tangential stress.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668109
10AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats in the triptorelin-induced ovarian suppression experiment, vessel walls showed no significant histological alterations.
In plain wordsIn rats in the triptorelin-induced ovarian suppression experiment, vessel wall tissue showed no significant changes.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeVessel wall histology
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
No significant histological alterations were seen in the vessel wall.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668110
11AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In rats, oestradiol was lower after triptorelin-induced ovarian suppression than in controls and oestradiol-replaced animals.
In plain wordsIn rats, oestradiol was lower after triptorelin-induced ovarian suppression than in controls and animals receiving oestradiol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum oestradiol
Study
ratn: not reported in source
Female Sprague-Dawley rats with pharmacological ovariectomy
Comparator
Vehicle controls and oestradiol-replaced animals
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Oestradiol levels were significantly decreased in the castrated animals compared with the other two groups.
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty non-pregnant female Sprague-Dawley rats.
Summary · context
Twenty animals were pharmacologically ovariectomised by triptorelin and received either oestradiol propionate or its vehicle.
Summary · context
Ten other animals received only the vehicle for the same period of time (control group).
Summary · context
After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1042668111

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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