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Study · Randomized controlled trial · n = 7 · 1999

8 results

Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans.

Bisi G, Podio V, Valetto MR, Broglio F, Bertuccio G, Del Rio G, Arvat E, Boghen MF, Deghenghi R, Muccioli G, Ong H, Ghigo E

Journal of endocrinological investigation1 Apr 1999Cited by 53 (Europe PMC)

PMID10342360 (opens in a new tab)DOI10.1007/bf03343555 (opens in a new tab)PepBankPUB-10342360
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male volunteers, hexarelin and rhGH increased circulating GH levels to the same extent.

    In plain wordsIn healthy men, hexarelin raised growth hormone levels as much as injected growth hormone did.

    Peptide
    Hexarelin
    Outcome
    IncreaseCirculating GH after hexarelin versus rhGH
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    GH AUC(90 min)
    1739.3 microg/l/min
    hexarelin
    GH AUC(90 min)
    1594.6 microg/l/min
    rhGH

    Source sentences

    Summary
    The administration of rhGH or HEX increased circulating GH levels to the same extent (AUC: 1594.6+/-88.1 vs 1739.3+/-262.2 microg/l/min for 90 min)
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male volunteers, aldosterone levels did not change after hexarelin or rhGH.

    In plain wordsIn healthy men, aldosterone did not change after hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeAldosterone
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    while aldosterone and catecholamine levels did not change
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male volunteers, catecholamine levels did not change after hexarelin or rhGH.

    In plain wordsIn healthy men, catecholamines did not change after hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeCatecholamines
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    while aldosterone and catecholamine levels did not change
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In male volunteers, hexarelin, but not rhGH, significantly increased cortisol levels.

    In plain wordsIn healthy men, hexarelin raised cortisol, but injected growth hormone did not.

    Peptide
    Hexarelin
    Outcome
    IncreaseCortisol after hexarelin versus rhGH
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    HEX, but not rhGH, significantly increased cortisol levels.
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In male volunteers, hexarelin significantly increased left ventricular ejection fraction.

    In plain wordsIn healthy men, hexarelin increased the heart's pumping fraction.

    Peptide
    Hexarelin
    Outcome
    IncreaseLeft ventricular ejection fraction
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    LVEF
    70.7%
    after hexarelin
    LVEF
    64%
    before hexarelin

    Source sentences

    Summary
    HEX increased LVEF (70.7+/-3.0 vs 64.0+/-1.5%, p<0.03)
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In male volunteers, hexarelin did not significantly change mean blood pressure.

    In plain wordsIn healthy men, hexarelin did not change blood pressure.

    Peptide
    Hexarelin
    Outcome
    No significant changeMean blood pressure
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    MBP
    92.8 mm Hg
    after hexarelin
    MBP
    92.4 mm Hg
    before hexarelin

    Source sentences

    Summary
    without significant changes in MBP and HR (92.8+/-4.7 vs 92.4+/-3.2 mm Hg, 63.1+/-2.1 vs 67.0+/-2.9 bpm).
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In male volunteers, hexarelin did not significantly change heart rate.

    In plain wordsIn healthy men, hexarelin did not change heart rate.

    Peptide
    Hexarelin
    Outcome
    No significant changeHeart rate
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    HR
    63.1 bpm
    after hexarelin
    HR
    67 bpm
    before hexarelin

    Source sentences

    Summary
    without significant changes in MBP and HR (92.8+/-4.7 vs 92.4+/-3.2 mm Hg, 63.1+/-2.1 vs 67.0+/-2.9 bpm).
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In male volunteers, ejection fraction rose significantly at 15 min after hexarelin, peaked at 30 min and lasted up to 60 min.

    In plain wordsIn healthy men, the heart's pumping fraction rose within 15 minutes of hexarelin, peaked at 30 minutes and lasted up to 60 minutes.

    Peptide
    Hexarelin
    Outcome
    IncreaseTime course of left ventricular ejection fraction
    Study

    n = 7

    Comparator
    rhGH
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    LVEF significantly raised at 15 min, peaked at 30 min and lasted up to 60 min after HEX.
    1 context sentence
    Summary · context
    In 7 male volunteers, we studied cardiac performance by radionuclide angiocardiography after iv administration of rhGH or hexarelin (HEX), a peptidyl GHS.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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