The effects of dose, nutrition, and age on hexarelin-induced anterior pituitary hormone secretion in adult patients on maintenance hemodialysis.

Jenkins RC, El Nahas AM, Wilkie ME, Brown CB, Jones J, Ghigo E, Ross RJ

The Journal of clinical endocrinology and metabolism1 Apr 1999Cited by 1 (Europe PMC)

PMID10199757DOI10.1210/jcem.84.4.5635PepBankPUB-10199757

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanNon-randomized trialEfficacy outcome
In well nourished hemodialysis patients, hexarelin at the higher dose increased GH secretion more than placebo.
In plain wordsIn well nourished dialysis patients, hexarelin raised growth hormone more than placebo.
Peptide
Hexarelin
Outcome
IncreaseGH secretion after 2 microg/kg versus placebo
Study
n = 6
Comparator
placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 microg/kg · intravenousAs given in this study (human).
Measurements
GH AUC(0-180 min)
10.7 min/U x L
2 microg/kg
GH AUC(0-180 min)
0.6 min/U x L
placebo
Source sentences
Summary
GH secretion (area under the curve over 180 min, mean +/- SE) after 2 and 1 microg/kg doses (10.7 +/- 4.2 and 8.2 +/- 5.2 min/U x L, respectively) was greater than after placebo (0.60 +/- 0.11 min/U x L; P < 0.001 and P < 0.05, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975701
02HumanNon-randomized trialEfficacy outcome
In well nourished hemodialysis patients, hexarelin at the lower dose increased GH secretion more than placebo.
In plain wordsIn well nourished dialysis patients, a lower hexarelin dose raised growth hormone more than placebo.
Peptide
Hexarelin
Outcome
IncreaseGH secretion after 1 microg/kg versus placebo
Study
n = 6
Comparator
placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microg/kg · intravenousAs given in this study (human).
Measurements
GH AUC(0-180 min)
8.2 min/U x L
1 microg/kg
GH AUC(0-180 min)
0.6 min/U x L
placebo
Source sentences
Summary
GH secretion (area under the curve over 180 min, mean +/- SE) after 2 and 1 microg/kg doses (10.7 +/- 4.2 and 8.2 +/- 5.2 min/U x L, respectively) was greater than after placebo (0.60 +/- 0.11 min/U x L; P < 0.001 and P < 0.05, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975702
03HumanNon-randomized trialEfficacy outcome
In healthy controls, the most effective hexarelin dose produced GH secretion similar to that in hemodialysis patients.
In plain wordsIn healthy adults, hexarelin raised growth hormone about as much as in dialysis patients.
Peptide
Hexarelin
Outcome
No significant changeGH secretion in healthy controls
Study
n = 6
Comparator
well nourished hemodialysis patients
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 microg/kg · intravenousAs given in this study (human).
Measurements
GH AUC(0-180 min)
11.4 min/U x L
healthy controls
Source sentences
Summary
The most effective dose (2 microg/kg) produced similar GH secretion (11.4 +/- 3.3 min/U x L) in controls.
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975703
04HumanNon-randomized trialEfficacy outcome
GH secretion in younger poorly nourished hemodialysis patients was not significantly different from that in well nourished patients.
In plain wordsHexarelin raised growth hormone in younger malnourished dialysis patients about as much as in well nourished patients.
Peptide
Hexarelin
Outcome
No significant changeGH secretion in younger poorly nourished versus well nourished patients
Study
n: not reported in source
Comparator
well nourished hemodialysis patients aged 20 to 40
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 microg/kg · intravenousAs given in this study (human).
Measurements
GH AUC(0-180 min)
19 min/U x L
younger poorly nourished
Source sentences
Summary
GH secretion in the younger poorly nourished HD group (19.0 +/- 4.4 min/U x L) was not significantly different from that in the well nourished 20- to 40-yr-old HD patients (P = 0.06).
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975704
05HumanNon-randomized trialEfficacy outcome
GH secretion in older poorly nourished hemodialysis patients was similar to that in younger poorly nourished patients.
In plain wordsHexarelin raised growth hormone in older malnourished dialysis patients about as much as in younger ones.
Peptide
Hexarelin
Outcome
No significant changeGH secretion in older versus younger poorly nourished patients
Study
n: not reported in source
Comparator
younger poorly nourished hemodialysis patients
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 microg/kg · intravenousAs given in this study (human).
Measurements
GH AUC(0-180 min)
9.4 min/U x L
older poorly nourished
Source sentences
Summary
GH secretion in the older, poorly nourished HD patients (9.4 +/- 2.2 min/U x L) was similar to that in the young, poorly nourished group (P = 0.18).
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975705
06HumanNon-randomized trialEfficacy outcome
In hemodialysis patients and controls, ACTH concentrations increased after hexarelin in all groups.
In plain wordsIn dialysis patients and healthy adults, ACTH rose after hexarelin in every group.
Peptide
Hexarelin
Outcome
IncreaseACTH concentration
Study
n: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
ACTH and cortisol concentrations increased in all groups
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975706
07HumanNon-randomized trialEfficacy outcome
In hemodialysis patients and controls, cortisol concentrations increased after hexarelin in all groups.
In plain wordsIn dialysis patients and healthy adults, cortisol rose after hexarelin in every group.
Peptide
Hexarelin
Outcome
IncreaseCortisol concentration
Study
n: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
ACTH and cortisol concentrations increased in all groups
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975707
08HumanNon-randomized trialEfficacy outcome
In patients with chronic renal failure, prolactin concentrations were not affected by hexarelin.
In plain wordsIn patients with kidney failure, hexarelin did not change prolactin.
Peptide
Hexarelin
Outcome
No significant changePRL concentration in chronic renal failure
Study
n: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
whereas PRL concentrations were not affected in CRF.
1 context sentence(design, population, supporting numbers)
Summary · context
An iv dose-response study in six 20- to 40-yr-old well nourished hemodialysis (HD) patients was followed by administration of the maximally effective dose to six 20- to 40-yr-old healthy controls, six 20- to 40-yr-old poorly nourished HD patients, and six 50- to 70-yr-old poorly nourished HD patients.
Report a problemFND-1019975708

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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