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Study · Non-randomized trial · n = 21 · 1998

10 results

The effect of body composition on hexarelin-induced growth hormone release in normal elderly subjects.

Rahim A, O'Neill P, Shalet SM

Clinical endocrinology1 Nov 1998Cited by 2 (Europe PMC)

PMID10197083 (opens in a new tab)DOI10.1046/j.1365-2265.1998.00586.x (opens in a new tab)PepBankPUB-10197083
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, peak GH response to subcutaneous hexarelin correlated negatively with fat mass (r = -0.72, P = 0.0001).

    In plain wordsIn healthy older adults, people with more body fat had a smaller peak growth hormone rise after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreasePeak GH response versus fat mass
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    Correlation r
    −0.72 r
    peak GH vs fat mass

    Source sentences

    Summary
    Peak GH response correlated negatively with fat mass, BMI, percentage body fat, and weight [r = -0.72, P = 0.0001; r = -0.56, P = 0.009; r = -0.63, P = 0.002 and r = -0.48, P = 0.029, respectively,].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, peak GH response to hexarelin correlated negatively with BMI (r = -0.56, P = 0.009).

    In plain wordsIn healthy older adults, a higher BMI was linked to a smaller peak growth hormone rise after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreasePeak GH response versus BMI
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    Correlation r
    −0.56 r
    peak GH vs BMI

    Source sentences

    Summary
    Peak GH response correlated negatively with fat mass, BMI, percentage body fat, and weight [r = -0.72, P = 0.0001; r = -0.56, P = 0.009; r = -0.63, P = 0.002 and r = -0.48, P = 0.029, respectively,].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, peak GH response to hexarelin correlated negatively with percentage body fat (r = -0.63, P = 0.002).

    In plain wordsIn healthy older adults, a higher percentage of body fat was linked to a smaller peak growth hormone rise after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreasePeak GH response versus percentage body fat
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    Correlation r
    −0.63 r
    peak GH vs percentage body fat

    Source sentences

    Summary
    Peak GH response correlated negatively with fat mass, BMI, percentage body fat, and weight [r = -0.72, P = 0.0001; r = -0.56, P = 0.009; r = -0.63, P = 0.002 and r = -0.48, P = 0.029, respectively,].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, peak GH response to hexarelin correlated negatively with weight (r = -0.48, P = 0.029).

    In plain wordsIn healthy older adults, higher body weight was linked to a smaller peak growth hormone rise after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreasePeak GH response versus body weight
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    Correlation r
    −0.48 r
    peak GH vs weight

    Source sentences

    Summary
    Peak GH response correlated negatively with fat mass, BMI, percentage body fat, and weight [r = -0.72, P = 0.0001; r = -0.56, P = 0.009; r = -0.63, P = 0.002 and r = -0.48, P = 0.029, respectively,].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  5. 05HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, AUC GH after hexarelin correlated negatively with fat mass (r = -0.58, P = 0.006).

    In plain wordsIn healthy older adults, more body fat was linked to a smaller total growth hormone response after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH AUC versus fat mass
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    Correlation r
    −0.58 r
    AUC GH vs fat mass

    Source sentences

    Summary
    AUC GH correlated negatively with fat mass, BMI and percentage fat mass [r = -0.58, P = 0.006; r = -0.51, P = 0.019 and r = -0.66, P = 0.001 respectively].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  6. 06HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, AUC GH after hexarelin correlated negatively with BMI (r = -0.51, P = 0.019).

    In plain wordsIn healthy older adults, a higher BMI was linked to a smaller total growth hormone response after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH AUC versus BMI
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    Correlation r
    −0.51 r
    AUC GH vs BMI

    Source sentences

    Summary
    AUC GH correlated negatively with fat mass, BMI and percentage fat mass [r = -0.58, P = 0.006; r = -0.51, P = 0.019 and r = -0.66, P = 0.001 respectively].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  7. 07HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, AUC GH after hexarelin correlated negatively with percentage fat mass (r = -0.66, P = 0.001).

    In plain wordsIn healthy older adults, a higher percentage of body fat was linked to a smaller total growth hormone response after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH AUC versus percentage fat mass
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    Correlation r
    −0.66 r
    AUC GH vs percentage fat mass

    Source sentences

    Summary
    AUC GH correlated negatively with fat mass, BMI and percentage fat mass [r = -0.58, P = 0.006; r = -0.51, P = 0.019 and r = -0.66, P = 0.001 respectively].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  8. 08HumanNon-randomized trialEfficacy outcome

    In multiple linear regression in healthy elderly subjects, fat mass was the most useful predictor of peak GH response to hexarelin (R2 = 0.61, P < 0.0001).

    In plain wordsIn healthy older adults, body fat mass was the best predictor of the peak growth hormone rise after hexarelin.

    Peptide
    Hexarelin
    Outcome
    Not applicableFat mass as predictor of peak GH response
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    R2
    0.61
    peak GH response

    Source sentences

    Summary
    Using multiple linear regression, fat mass was the most useful predictor for both peak GH response [R2 = 0.61, P < 0.0001] and AUC GH [R2 = 0.38, P = 0.003].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  9. 09HumanNon-randomized trialEfficacy outcome

    In multiple linear regression in healthy elderly subjects, fat mass was the most useful predictor of AUC GH after hexarelin (R2 = 0.38, P = 0.003).

    In plain wordsIn healthy older adults, body fat mass was the best predictor of the total growth hormone response after hexarelin.

    Peptide
    Hexarelin
    Outcome
    Not applicableFat mass as predictor of GH AUC
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Measurements

    R2
    0.38
    AUC GH

    Source sentences

    Summary
    Using multiple linear regression, fat mass was the most useful predictor for both peak GH response [R2 = 0.61, P < 0.0001] and AUC GH [R2 = 0.38, P = 0.003].
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.
  10. 10HumanNon-randomized trialEfficacy outcome

    In healthy elderly subjects, gender was not a significant variable for the GH response to hexarelin.

    In plain wordsIn healthy older adults, sex did not significantly affect the growth hormone response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeGender effect on GH response
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 micrograms per kg of body weight · subcutaneous · single bolusAs given in this study (human).

    Source sentences

    Summary
    Gender was not a significant variable.
    2 context sentences
    Summary · context
    A single bolus of subcutaneous hexarelin at a dose of 1.5 micrograms per kg of body weight was administered at time 0.
    Summary · context
    Twenty-one (eight male) healthy elderly subjects with a median (range) age of 68 (60-81) years and BMI of 26 (19-30) kg/m2 were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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