Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of Hexarelin and GHRP-2 in humans.

Arvat E, Di Vito L, Lanfranco F, Broglio F, Giordano R, Benso A, Muccioli GP, Deghenghi R, Ghigo E

Journal of endocrinological investigation1 Feb 1999Cited by 9 (Europe PMC)

PMID10195374DOI10.1007/bf03350886PepBankPUB-10195374

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. 12 results from people.

01HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, intravenous hexarelin 2.0 microg/kg induced a strong GH response (Cmax 77.3 microg/l).
In plain wordsIn 7 young adults, hexarelin by injection caused a strong rise in growth hormone.
Peptide
Hexarelin
Outcome
IncreaseGH response (Cmax and AUC)
Study
n = 7
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
GH Cmax
77.3 microg/l
hexarelin
GH AUC
2596.7 microg*min/l
hexarelin
Source sentences
Summary
HEX and GHRP-2 administration induced the well known strong GH response (Cmax, mean+/-SE: 77.3+/-6.0 and 74.1+/-12.1 microg/l; AUC, mean+/-SE: 2596.7+/-251.1 and 2480.0+/-343.6 microg*min/l).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537401
02HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, intravenous GHRP‑2 2.0 microg/kg induced a strong GH response (Cmax 74.1 microg/l).
In plain wordsIn 7 young adults, GHRP‑2 by injection caused a strong rise in growth hormone.
Peptide
GHRP-2
Outcome
IncreaseGH response (Cmax and AUC)
Study
n = 7
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
GH Cmax
74.1 microg/l
GHRP-2
GH AUC
2480 microg*min/l
GHRP-2
Source sentences
Summary
HEX and GHRP-2 administration induced the well known strong GH response (Cmax, mean+/-SE: 77.3+/-6.0 and 74.1+/-12.1 microg/l; AUC, mean+/-SE: 2596.7+/-251.1 and 2480.0+/-343.6 microg*min/l).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537402
03HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, the GH response to hexarelin was similar to that induced by Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, hexarelin and Tyr-Ala-hexarelin caused a similar growth hormone rise.
Peptide
Hexarelin
Outcome
No significant changeGH response versus Tyr-Ala-hexarelin
Study
n = 7
Comparator
Tyr-Ala-hexarelin
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
These responses were similar to that induced by Tyr-Ala-HEX (63.7+/-18.5 microg/l; 1986.6+/-622.4 microg*min/l).
2 context sentences(design, population, supporting numbers)
Summary · context
HEX and GHRP-2 administration induced the well known strong GH response (Cmax, mean+/-SE: 77.3+/-6.0 and 74.1+/-12.1 microg/l; AUC, mean+/-SE: 2596.7+/-251.1 and 2480.0+/-343.6 microg*min/l).
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537403
04HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, the GH response to GHRP‑2 was similar to that induced by Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, GHRP‑2 and Tyr-Ala-hexarelin caused a similar growth hormone rise.
Peptide
GHRP-2
Outcome
No significant changeGH response versus Tyr-Ala-hexarelin
Study
n = 7
Comparator
Tyr-Ala-hexarelin
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
These responses were similar to that induced by Tyr-Ala-HEX (63.7+/-18.5 microg/l; 1986.6+/-622.4 microg*min/l).
2 context sentences(design, population, supporting numbers)
Summary · context
HEX and GHRP-2 administration induced the well known strong GH response (Cmax, mean+/-SE: 77.3+/-6.0 and 74.1+/-12.1 microg/l; AUC, mean+/-SE: 2596.7+/-251.1 and 2480.0+/-343.6 microg*min/l).
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537404
05HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, hexarelin significantly stimulated PRL (Cmax 14.9 microg/l), the same effect as GHRP-2 and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, hexarelin raised prolactin, as did GHRP-2 and Tyr-Ala-hexarelin.
Peptide
Hexarelin
Outcome
IncreaseProlactin (PRL) response
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
PRL Cmax
14.9 microg/l
hexarelin
PRL AUC
497.8 microg*min/l
hexarelin
Source sentences
Summary
HEX, GHRP-2 and Tyr-Ala-HEX had the same significant stimulatory effect on PRL (14.9+/-2.5, 12.3+/-2.0 and 10.0+/-1.5 microg/l; 497.8+/-61.8, 480.4+/-66.9 and 415.8+/-58.5 microg*min/l)
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537405
06HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, GHRP‑2 significantly stimulated PRL (Cmax 12.3 microg/l), the same effect as hexarelin and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, GHRP‑2 raised prolactin, as did hexarelin and Tyr-Ala-hexarelin.
Peptide
GHRP-2
Outcome
IncreaseProlactin (PRL) response
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
PRL Cmax
12.3 microg/l
GHRP-2
PRL AUC
480.4 microg*min/l
GHRP-2
Source sentences
Summary
HEX, GHRP-2 and Tyr-Ala-HEX had the same significant stimulatory effect on PRL (14.9+/-2.5, 12.3+/-2.0 and 10.0+/-1.5 microg/l; 497.8+/-61.8, 480.4+/-66.9 and 415.8+/-58.5 microg*min/l)
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537406
07HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, hexarelin significantly stimulated ACTH (Cmax 48.0 pg/ml), the same effect as GHRP-2 and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, hexarelin raised ACTH, as did GHRP-2 and Tyr-Ala-hexarelin.
Peptide
Hexarelin
Outcome
IncreaseACTH response
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
ACTH Cmax
48 pg/ml
hexarelin
ACTH AUC
1531.6 pg*min/ml
hexarelin
Source sentences
Summary
ACTH (48.0+/-10.1, 51.4+/-10.6 and 44.9+/-12.2 pg/ml; 1531.6+/-235.7, 1586.7+/-277.0 and 1338.1+/-164.5 pg*min/ml)
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537407
08HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, GHRP‑2 significantly stimulated ACTH (Cmax 51.4 pg/ml), the same effect as hexarelin and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, GHRP‑2 raised ACTH, as did hexarelin and Tyr-Ala-hexarelin.
Peptide
GHRP-2
Outcome
IncreaseACTH response
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
ACTH Cmax
51.4 pg/ml
GHRP-2
ACTH AUC
1586.7 pg*min/ml
GHRP-2
Source sentences
Summary
ACTH (48.0+/-10.1, 51.4+/-10.6 and 44.9+/-12.2 pg/ml; 1531.6+/-235.7, 1586.7+/-277.0 and 1338.1+/-164.5 pg*min/ml)
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537408
09HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, hexarelin significantly stimulated cortisol (Cmax 179.9 microg/l), the same effect as GHRP-2 and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, hexarelin raised cortisol, as did GHRP-2 and Tyr-Ala-hexarelin.
Peptide
Hexarelin
Outcome
IncreaseCortisol response
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
cortisol Cmax
179.9 microg/l
hexarelin
cortisol AUC
8465 microg*min/l
hexarelin
Source sentences
Summary
cortisol (179.9+/-10.0, 181.2+/-14.1 and 149.7+/-20.1 microg/l; 8465.0+/-406.6, 8689.2+/-788.1 and 6295.2+/-797.0 microg*min/l)
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537409
10HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, GHRP‑2 significantly stimulated cortisol (Cmax 181.2 microg/l), the same effect as hexarelin and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, GHRP‑2 raised cortisol, as did hexarelin and Tyr-Ala-hexarelin.
Peptide
GHRP-2
Outcome
IncreaseCortisol response
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Measurements
cortisol Cmax
181.2 microg/l
GHRP-2
cortisol AUC
8689.2 microg*min/l
GHRP-2
Source sentences
Summary
cortisol (179.9+/-10.0, 181.2+/-14.1 and 149.7+/-20.1 microg/l; 8465.0+/-406.6, 8689.2+/-788.1 and 6295.2+/-797.0 microg*min/l)
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537410
11HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, the mean Tmax of the endocrine responses to hexarelin was similar to that of GHRP-2 and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, the time to peak hormone response was similar for hexarelin, GHRP-2 and Tyr-Ala-hexarelin.
Peptide
Hexarelin
Outcome
No significant changeTmax of endocrine responses
Study
n = 7
Comparator
Tyr-Ala-hexarelin
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
Also the mean Tmax of the endocrine responses to HEX, GHRP-2 and Tyr-Ala-HEX were similar.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537411
12HumanNon-randomized trialEfficacy outcome
In 7 young adult volunteers, the mean Tmax of the endocrine responses to GHRP‑2 was similar to that of hexarelin and Tyr-Ala-hexarelin.
In plain wordsIn 7 young adults, the time to peak hormone response was similar for GHRP‑2, hexarelin and Tyr-Ala-hexarelin.
Peptide
GHRP-2
Outcome
No significant changeTmax of endocrine responses
Study
n = 7
Comparator
Tyr-Ala-hexarelin
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
Also the mean Tmax of the endocrine responses to HEX, GHRP-2 and Tyr-Ala-HEX were similar.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the endocrine activities of Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of the maximal effective dose of HEX (2.0 microg/kg i.v.) or GHRP-2 (2.0 microg/kg i.v.) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels.
Report a problemFND-1019537412

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 5 to 19Current
28 Oct 2026, 02:02 UTC
The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.
Study results updated
Versions 3 to 4
13 Oct 2026, 16:31 UTC
The same notice was added 2 times, first on 13 Oct 2026, 16:31 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of Hexarelin and GHRP-2 in humans.

Summary

Results from this study12

Version history

Subjects

Publication types

MeSH terms