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Study · Case report or series · n = 4 · 1999

4 results

Selective lack of growth hormone (GH) response to the GH-releasing peptide hexarelin in patients with GH-releasing hormone receptor deficiency.

Maheshwari HG, Rahim A, Shalet SM, Baumann G

The Journal of clinical endocrinology and metabolism1 Mar 1999Cited by 36 (Europe PMC)

PMID10084578 (opens in a new tab)DOI10.1210/jcem.84.3.5523 (opens in a new tab)PepBankPUB-10084578
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In four men with GHRH receptor deficiency, hexarelin caused no rise in plasma GH.

    In plain wordsIn four men with GHRH receptor deficiency, hexarelin did not raise growth hormone.

    Peptide
    Hexarelin
    Outcome
    No significant changePlasma GH response to hexarelin
    Study

    n = 4

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Measurements

    Plasma GH
    < 1 ng/mL
    after hexarelin

    Source sentences

    Summary
    Intravenous administration of hexarelin (2 microg/kg) to four male adult patients (dwarfs of Sindh) resulted in a complete lack of elevation in plasma GH levels (< 1 ng/mL), an at least 50- to 100-fold deviation from the normal response.
    1 context sentence
    Summary · context
    We report the response to hexarelin, a potent GHRP, in patients affected with a homozygous mutation in the GHRH receptor gene, with consequent GHRH resistance and GH-deficient dwarfism.
  2. 02HumanCase report or seriesEfficacy outcome

    In men with GHRH receptor deficiency, plasma prolactin rose in a normal manner after hexarelin.

    In plain wordsIn men with GHRH receptor deficiency, hexarelin raised prolactin as normal.

    Peptide
    Hexarelin
    Outcome
    IncreasePlasma PRL response to hexarelin
    Study

    n = 4

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    In contrast, plasma PRL, ACTH, and cortisol levels rose in a normal manner in response to hexarelin.
    1 context sentence
    Summary · context
    We report the response to hexarelin, a potent GHRP, in patients affected with a homozygous mutation in the GHRH receptor gene, with consequent GHRH resistance and GH-deficient dwarfism.
  3. 03HumanCase report or seriesEfficacy outcome

    In men with GHRH receptor deficiency, plasma ACTH rose in a normal manner after hexarelin.

    In plain wordsIn men with GHRH receptor deficiency, hexarelin raised ACTH as normal.

    Peptide
    Hexarelin
    Outcome
    IncreasePlasma ACTH response to hexarelin
    Study

    n = 4

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    In contrast, plasma PRL, ACTH, and cortisol levels rose in a normal manner in response to hexarelin.
    1 context sentence
    Summary · context
    We report the response to hexarelin, a potent GHRP, in patients affected with a homozygous mutation in the GHRH receptor gene, with consequent GHRH resistance and GH-deficient dwarfism.
  4. 04HumanCase report or seriesEfficacy outcome

    In men with GHRH receptor deficiency, plasma cortisol rose in a normal manner after hexarelin.

    In plain wordsIn men with GHRH receptor deficiency, hexarelin raised cortisol as normal.

    Peptide
    Hexarelin
    Outcome
    IncreasePlasma cortisol response to hexarelin
    Study

    n = 4

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    In contrast, plasma PRL, ACTH, and cortisol levels rose in a normal manner in response to hexarelin.
    1 context sentence
    Summary · context
    We report the response to hexarelin, a potent GHRP, in patients affected with a homozygous mutation in the GHRH receptor gene, with consequent GHRH resistance and GH-deficient dwarfism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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