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Study · Animal study (in vivo) · rabbit · 1999

7 results

Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation.

Sebecić B, Nikolić V, Sikirić P, Seiwerth S, Sosa T, Patrlj L, Grabarević Z, Rucman R, Petek M, Konjevoda P, Jadrijević S, Perović D, Slaj M

Bone1 Mar 1999Cited by 46 (Europe PMC)

PMID10071911 (opens in a new tab)DOI10.1016/s8756-3282(98)00180-x (opens in a new tab)PepBankPUB-10071911
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with a segmental radius defect, BPC‑157 significantly improved healing of the bone defect compared with controls that stayed incompletely healed.

    In plain wordsIn rabbits with a bone defect, BPC‑157 improved bone healing compared with saline controls.

    Peptide
    BPC-157
    Outcome
    IncreaseHealing of segmental bone defect
    Study

    rabbitn: not reported in source

    Segmental osteoperiosteal radius defect
    Comparator
    Saline controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg or 10 ng/kg · local, intramuscularAs given in this study (rabbit).

    Source sentences

    Summary
    Pentadecapeptide BPC-157 significantly improved the healing of segmental bone defects.
    1 context sentence
    Summary · context
    using a segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) that remained incompletely healed in all control rabbits for 6 weeks (assessed in 2 week intervals)
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, the BPC‑157 effect on callus surface corresponded to the improvement after local bone marrow or autologous cortical graft.

    In plain wordsIn rabbits, BPC‑157 improved callus surface about as much as bone marrow or a bone graft.

    Peptide
    BPC-157
    Outcome
    IncreaseCallus surface on radiography
    Study

    rabbitn: not reported in source

    Segmental osteoperiosteal radius defect
    Comparator
    Autologous bone marrow and autologous cortical graft
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg i.m. for 14 days · intramuscular · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    For instance, upon radiographic assessment, the callus surface, microphotodensitometry, quantitative histomorphometry (10 microg/kg body weight i.m. for 14 days), or quantitative histomorphometry (10 ng/kg body weight i.m. for 14 days) the effect of pentadecapeptide BPC-157 was shown to correspond t…
    1 context sentence
    Summary · context
    using a segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) that remained incompletely healed in all control rabbits for 6 weeks (assessed in 2 week intervals)
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, the BPC‑157 effect on microphotodensitometry corresponded to the improvement after local bone marrow or autologous cortical graft.

    In plain wordsIn rabbits, BPC‑157 improved bone density measures about as much as bone marrow or a bone graft.

    Peptide
    BPC-157
    Outcome
    IncreaseMicrophotodensitometry
    Study

    rabbitn: not reported in source

    Segmental osteoperiosteal radius defect
    Comparator
    Autologous bone marrow and autologous cortical graft
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg i.m. for 14 days · intramuscular · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    For instance, upon radiographic assessment, the callus surface, microphotodensitometry, quantitative histomorphometry (10 microg/kg body weight i.m. for 14 days), or quantitative histomorphometry (10 ng/kg body weight i.m. for 14 days) the effect of pentadecapeptide BPC-157 was shown to correspond t…
    1 context sentence
    Summary · context
    using a segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) that remained incompletely healed in all control rabbits for 6 weeks (assessed in 2 week intervals)
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, the BPC‑157 effect on quantitative histomorphometry at both doses corresponded to the improvement after local bone marrow or autologous cortical graft.

    In plain wordsIn rabbits, BPC‑157 improved bone tissue structure about as much as bone marrow or a bone graft.

    Peptide
    BPC-157
    Outcome
    IncreaseQuantitative histomorphometry
    Study

    rabbitn: not reported in source

    Segmental osteoperiosteal radius defect
    Comparator
    Autologous bone marrow and autologous cortical graft
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg or 10 ng/kg i.m. for 14 days · intramuscular · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    For instance, upon radiographic assessment, the callus surface, microphotodensitometry, quantitative histomorphometry (10 microg/kg body weight i.m. for 14 days), or quantitative histomorphometry (10 ng/kg body weight i.m. for 14 days) the effect of pentadecapeptide BPC-157 was shown to correspond t…
    1 context sentence
    Summary · context
    using a segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) that remained incompletely healed in all control rabbits for 6 weeks (assessed in 2 week intervals)
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, 14 days of intramuscular BPC‑157 increased the number of animals with a healed defect compared with controls, in which all defects were unhealed.

    In plain wordsIn rabbits, BPC‑157 injected into muscle for 14 days gave more healed bone defects than saline, where none healed.

    Peptide
    BPC-157
    Outcome
    IncreaseAnimals with healed defect, intramuscular for 14 days
    Study

    rabbitn: not reported in source

    Segmental osteoperiosteal radius defect
    Comparator
    Saline controls (all unhealed)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg or 10 ng/kg · intramuscular · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    besides pentadecapeptide intramuscular application for 14 days (i.e., local application of bone marrow or autologous cortical graft), also following other pentadecapeptide BPC-157 regimens (local application, or intermittent intramuscular administration), the number of animals with healed defect was increased
    1 context sentence
    Summary · context
    a comparison of the number of animals with unhealed defects (all controls) or healed defects (complete bony continuity across the defect site)
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, local BPC‑157 into the defect increased the number of animals with a healed defect compared with controls, in which all defects were unhealed.

    In plain wordsIn rabbits, BPC‑157 given into the bone defect gave more healed defects than saline, where none healed.

    Peptide
    BPC-157
    Outcome
    IncreaseAnimals with healed defect, local application
    Study

    rabbitn: not reported in source

    Segmental osteoperiosteal radius defect
    Comparator
    Saline controls (all unhealed)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg · local, percutaneous into the defectAs given in this study (rabbit).

    Source sentences

    Summary
    besides pentadecapeptide intramuscular application for 14 days (i.e., local application of bone marrow or autologous cortical graft), also following other pentadecapeptide BPC-157 regimens (local application, or intermittent intramuscular administration), the number of animals with healed defect was increased
    1 context sentence
    Summary · context
    a comparison of the number of animals with unhealed defects (all controls) or healed defects (complete bony continuity across the defect site)
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, intermittent intramuscular BPC‑157 increased the number of animals with a healed defect compared with controls, in which all defects were unhealed.

    In plain wordsIn rabbits, intermittent BPC‑157 injections into muscle gave more healed bone defects than saline, where none healed.

    Peptide
    BPC-157
    Outcome
    IncreaseAnimals with healed defect, intermittent intramuscular
    Study

    rabbitn: not reported in source

    Segmental osteoperiosteal radius defect
    Comparator
    Saline controls (all unhealed)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg · intramuscular, intermittentAs given in this study (rabbit).

    Source sentences

    Summary
    besides pentadecapeptide intramuscular application for 14 days (i.e., local application of bone marrow or autologous cortical graft), also following other pentadecapeptide BPC-157 regimens (local application, or intermittent intramuscular administration), the number of animals with healed defect was increased
    1 context sentence
    Summary · context
    a comparison of the number of animals with unhealed defects (all controls) or healed defects (complete bony continuity across the defect site)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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