Ovarian hyperstimulation following the sole administration of agonistic analogues of gonadotrophin releasing hormone.

Weissman A, Barash A, Shapiro H, Casper RF

Human reproduction (Oxford, England)1 Dec 1998Cited by 21 (Europe PMC)

PMID9886527DOI10.1093/humrep/13.12.3421PepBankPUB-09886527

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanCase report or seriesSafety outcome
In an infertile IVF patient, mid-luteal depot triptorelin was followed by ovarian hyperstimulation.
In plain wordsIn an infertile IVF patient, ovarian hyperstimulation occurred after depot triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvarian hyperstimulation with depot triptorelin
Study
n = 1
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The first patient developed ovarian hyperstimulation on two occasions, with mid-luteal depot administration of triptorelin and with early follicular triptorelin, administered as daily subcutaneous injections.
2 context sentences(design, population, supporting numbers)
Summary · context
We hereby report on two infertile patients undergoing in-vitro fertilization-embryo transfer who developed ovarian hyperstimulation under such circumstances.
Summary · context
In both patients, GnRHa were administered using the 'long protocol' regimen.
Report a problemFND-0988652701
02HumanCase report or seriesSafety outcome
In the same infertile IVF patient, daily early-follicular triptorelin was followed by another episode of ovarian hyperstimulation.
In plain wordsIn the same infertile IVF patient, ovarian hyperstimulation occurred again after daily triptorelin injections.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvarian hyperstimulation with daily triptorelin
Study
n = 1
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
The first patient developed ovarian hyperstimulation on two occasions, with mid-luteal depot administration of triptorelin and with early follicular triptorelin, administered as daily subcutaneous injections.
2 context sentences(design, population, supporting numbers)
Summary · context
We hereby report on two infertile patients undergoing in-vitro fertilization-embryo transfer who developed ovarian hyperstimulation under such circumstances.
Summary · context
In both patients, GnRHa were administered using the 'long protocol' regimen.
Report a problemFND-0988652702
03HumanCase report or seriesSafety outcome
In an infertile IVF patient, massive ovarian multifollicular enlargement occurred within 2 weeks in both triptorelin cycles.
In plain wordsIn an infertile IVF patient, the ovaries enlarged markedly during both triptorelin cycles.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvarian multifollicular enlargement
Study
n = 1
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In both cycles, within 2 weeks of triptorelin therapy, massive ovarian multifollicular enlargement occurred, concomitant with high serum oestradiol concentrations, which resolved spontaneously following expectant management.
3 context sentences(design, population, supporting numbers)
Summary · context
We hereby report on two infertile patients undergoing in-vitro fertilization-embryo transfer who developed ovarian hyperstimulation under such circumstances.
Summary · context
In both patients, GnRHa were administered using the 'long protocol' regimen.
Summary · context
The first patient developed ovarian hyperstimulation on two occasions, with mid-luteal depot administration of triptorelin and with early follicular triptorelin, administered as daily subcutaneous injections.
Report a problemFND-0988652703
04HumanCase report or seriesSafety outcome
In an infertile IVF patient, high serum oestradiol accompanied ovarian enlargement during both triptorelin cycles.
In plain wordsIn an infertile IVF patient, high blood oestradiol accompanied ovarian enlargement during both triptorelin cycles.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedHigh serum oestradiol
Study
n = 1
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In both cycles, within 2 weeks of triptorelin therapy, massive ovarian multifollicular enlargement occurred, concomitant with high serum oestradiol concentrations, which resolved spontaneously following expectant management.
3 context sentences(design, population, supporting numbers)
Summary · context
We hereby report on two infertile patients undergoing in-vitro fertilization-embryo transfer who developed ovarian hyperstimulation under such circumstances.
Summary · context
In both patients, GnRHa were administered using the 'long protocol' regimen.
Summary · context
The first patient developed ovarian hyperstimulation on two occasions, with mid-luteal depot administration of triptorelin and with early follicular triptorelin, administered as daily subcutaneous injections.
Report a problemFND-0988652704
05HumanCase report or seriesSafety outcome
In an infertile IVF patient, ovarian hyperstimulation during both triptorelin cycles resolved spontaneously with expectant management.
In plain wordsIn an infertile IVF patient, ovarian hyperstimulation after triptorelin resolved spontaneously with observation.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableSpontaneous resolution of ovarian hyperstimulation
Study
n = 1
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In both cycles, within 2 weeks of triptorelin therapy, massive ovarian multifollicular enlargement occurred, concomitant with high serum oestradiol concentrations, which resolved spontaneously following expectant management.
3 context sentences(design, population, supporting numbers)
Summary · context
We hereby report on two infertile patients undergoing in-vitro fertilization-embryo transfer who developed ovarian hyperstimulation under such circumstances.
Summary · context
In both patients, GnRHa were administered using the 'long protocol' regimen.
Summary · context
The first patient developed ovarian hyperstimulation on two occasions, with mid-luteal depot administration of triptorelin and with early follicular triptorelin, administered as daily subcutaneous injections.
Report a problemFND-0988652705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

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