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Study · Animal study (in vivo) · rat · 1998

7 results

Central injection in rats of alpha-melanocyte-stimulating hormone analog: effects on food intake and brain Fos.

Brown KS, Gentry RM, Rowland NE

Regulatory peptides1 Nov 1998Cited by 70 (Europe PMC)

PMID9879751 (opens in a new tab)DOI10.1016/s0167-0115(98)00127-x (opens in a new tab)PepBankPUB-09879751
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In food-deprived rats, lateral cerebroventricular NDP-MSH inhibited food intake.

    In plain wordsIn rats, NDP-MSH given into the brain ventricle reduced food intake in hungry animals.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseFood intake in food-deprived rats after lateral ventricle injection
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    Lateral cerebroventricular (LCVT) administration of the alpha-MSH agonist analog Nle4DPhe7alpha-MSH (NDP-MSH) inhibited food intake in food-deprived rats, but did not inhibit water intake in water-deprived rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In water-deprived rats, lateral cerebroventricular NDP-MSH did not inhibit water intake.

    In plain wordsIn rats, NDP-MSH given into the brain ventricle did not reduce water intake in thirsty animals.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeWater intake in water-deprived rats after lateral ventricle injection
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    Lateral cerebroventricular (LCVT) administration of the alpha-MSH agonist analog Nle4DPhe7alpha-MSH (NDP-MSH) inhibited food intake in food-deprived rats, but did not inhibit water intake in water-deprived rats
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    NDP-MSH given into the fourth ventricle suppressed food intake in rats, comparable to the lateral ventricle route.

    In plain wordsIn rats, NDP-MSH given into the fourth brain ventricle reduced food intake, as it did with the lateral ventricle.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseFood intake after fourth ventricle injection
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (fourth ventricle)As given in this study (rat).

    Source sentences

    Summary
    When NDP-MSH was administered into the fourth ventricle (4CVT), comparable suppressions of food intake were observed.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    Lateral and fourth ventricle NDP-MSH reduced spontaneous 24 h food intake in rats.

    In plain wordsIn rats, NDP-MSH given into the brain ventricles reduced normal food intake over 24 hours.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseSpontaneous 24 h food intake
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (lateral and fourth ventricle)As given in this study (rat).

    Source sentences

    Summary
    LCVT and 4CVT administration of NDP-MSH also reduced spontaneous 24 h food intake.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In sated rats, lateral cerebroventricular NDP-MSH greatly attenuated the food intake that acute neuropeptide Y administration stimulated.

    In plain wordsIn rats, NDP-MSH given into the brain ventricle strongly reduced the extra eating caused by neuropeptide Y.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseNeuropeptide Y-stimulated food intake in sated rats
    Study

    ratn: not reported in source

    Comparator
    Neuropeptide Y alone
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    LCVT injection of NDP-MSH greatly attenuated food intake stimulated in sated rats by acute CVT administration of neuropeptide Y (NPY).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, lateral cerebroventricular NDP-MSH induced Fos-like immunoreactivity in forebrain regions including cortex, striatum, bed nucleus of the stria terminalis, paraventricular nucleus and arcuate nucleus.

    In plain wordsIn rats, NDP-MSH given into the brain ventricle switched on a neuronal activity marker in several forebrain regions.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseFos-like immunoreactive neurons in forebrain regions
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    LCVT injection of NDP-MSH induced Fos-ir in several forebrain regions including cortex, striatum, bed nucleus of the stria terminalis, paraventricular nucleus of the hypothalamus and arcuate nucleus.
    1 context sentence
    Summary · context
    In an attempt to assess further the sites of action of NDP-MSH, a qualitative mapping study of Fos-like immunoreactive (Fos-ir) neurons was performed following LCVT administration of NDP-MSH.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, adding NDP-MSH to the neuropeptide Y challenge produced no obvious antagonism or cancellation of Fos effects in any region examined.

    In plain wordsIn rats, adding NDP-MSH to a neuropeptide Y challenge did not cancel the brain activity marker effects in any region checked.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeFos-like immunoreactivity with NPY and NDP-MSH combined
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The combination of NPY and NDP-MSH did not produce obvious antagonism or cancellation of effects in any region examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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