Use of methylene blue in patients with refractory septic shock: impact on hemodynamics and gas exchange.

Andresen M, Dougnac A, Díaz O, Hernández G, Castillo L, Bugedo G, Alvarez M, Dagnino J

Journal of critical care1 Dec 1998Cited by 62 (Europe PMC)

PMID9869542DOI10.1016/s0883-9441(98)90001-6PepBankPUB-09869542

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanNon-randomized trialEfficacy outcome
In patients with refractory septic shock, methylene blue significantly increased systolic blood pressure from baseline.
In plain wordsMethylene blue increased systolic blood pressure compared with baseline in patients with refractory septic shock.
Peptide
Methylene blue
Outcome
IncreaseSystolic blood pressure
Study
n = 10
Comparator
Baseline
Outcome group
Blood pressure · Cardiovascular
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio.
3 context sentences(design, population, supporting numbers)
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954201
02HumanNon-randomized trialEfficacy outcome
In patients with refractory septic shock, methylene blue significantly increased diastolic blood pressure from baseline.
In plain wordsMethylene blue increased diastolic blood pressure compared with baseline in patients with refractory septic shock.
Peptide
Methylene blue
Outcome
IncreaseDiastolic blood pressure
Study
n = 10
Comparator
Baseline
Outcome group
Blood pressure · Cardiovascular
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio.
3 context sentences(design, population, supporting numbers)
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954202
03HumanNon-randomized trialEfficacy outcome
In patients with refractory septic shock, methylene blue significantly increased mean arterial blood pressure from baseline.
In plain wordsMethylene blue increased mean blood pressure compared with baseline in patients with refractory septic shock.
Peptide
Methylene blue
Outcome
IncreaseMean arterial blood pressure
Study
n = 10
Comparator
Baseline
Outcome group
Blood pressure · Cardiovascular
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio.
3 context sentences(design, population, supporting numbers)
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954203
04HumanNon-randomized trialEfficacy outcome
In patients with refractory septic shock, methylene blue significantly increased systemic vascular resistance from baseline.
In plain wordsMethylene blue increased blood vessel resistance compared with baseline in patients with refractory septic shock.
Peptide
Methylene blue
Outcome
IncreaseSystemic vascular resistance
Study
n = 10
Comparator
Baseline
Outcome group
Vascular function · Cardiovascular
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio.
3 context sentences(design, population, supporting numbers)
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954204
05HumanNon-randomized trialEfficacy outcome
In patients with refractory septic shock, cardiac output did not change significantly after methylene blue.
In plain wordsHeart blood output did not change significantly from baseline after methylene blue in patients with refractory septic shock.
Peptide
Methylene blue
Outcome
No significant changeCardiac output
Study
n = 10
Comparator
Baseline
Outcome group
Heart function · Cardiovascular
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio.
3 context sentences(design, population, supporting numbers)
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954205
06HumanNon-randomized trialEfficacy outcome
In patients with refractory septic shock, oxygen consumption did not change significantly after methylene blue.
In plain wordsOxygen consumption did not change significantly from baseline after methylene blue in patients with refractory septic shock.
Peptide
Methylene blue
Outcome
No significant changeOxygen consumption
Study
n = 10
Comparator
Baseline
Outcome group
Blood oxygenation and oxygen transport · Whole body
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio.
3 context sentences(design, population, supporting numbers)
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954206
07HumanNon-randomized trialEfficacy outcome
In patients with refractory septic shock, oxygen extraction ratio did not change significantly after methylene blue.
In plain wordsOxygen extraction did not change significantly from baseline after methylene blue in patients with refractory septic shock.
Peptide
Methylene blue
Outcome
No significant changeOxygen extraction ratio
Study
n = 10
Comparator
Baseline
Outcome group
Blood oxygenation and oxygen transport · Whole body
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio.
3 context sentences(design, population, supporting numbers)
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954207
08HumanNon-randomized trialEfficacy outcome
In septic shock patients with acute lung injury, gas exchange remained unaffected after methylene blue.
In plain wordsGas exchange remained unchanged from baseline after methylene blue in septic shock patients with acute lung injury.
Peptide
Methylene blue
Outcome
No significant changeGas exchange in acute lung injury
Study
n = 6
Comparator
Baseline
Outcome group
Respiratory function · Respiratory
Studied dose
1 mg/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Gas exchange remained unaffected in patients with acute lung injury.
4 context sentences(design, population, supporting numbers)
Summary · context
Six of them also developed acute lung injury.
Summary · context
Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs.
Summary · context
All received 1 mg/kg intravenous bolus of methylene blue.
Summary · context
Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
Report a problemFND-0986954208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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