Influence of galanin and serotonin on the endocrine response to Hexarelin, a synthetic peptidyl GH-secretagogue, in normal women.

Arvat E, Maccagno B, Ramunni J, Broglio F, Lanfranco F, Giordano R, Benso A, Deghenghi R, Ghigo E

Journal of endocrinological investigation1 Nov 1998Cited by 6 (Europe PMC)

PMID9854683DOI10.1007/bf03350797PepBankPUB-09854683

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialEfficacy outcome
In normal young volunteers, the GH response to hexarelin was higher than that to galanin alone.
In plain wordsIn healthy young adults, hexarelin raised growth hormone more than galanin alone.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin versus galanin alone
Study
n = 5
Comparator
Galanin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH response
1204.2 micrograms*min/L
hexarelin
GH response
305.6 micrograms*min/L
galanin alone
Source sentences
Summary
In group A, the GH response to HEX (1204.2 +/- 312.9 micrograms*min/L) was higher (p < 0.05) than that to GAL alone (305.6 +/- 35.5 micrograms*min/L) and was not modified by GAL co-administration (1021.8 +/- 249.9 micrograms*min/L).
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
Report a problemFND-0985468301
02HumanNon-randomized trialEfficacy outcome
In normal young volunteers, hexarelin and galanin increased prolactin secretion to the same extent.
In plain wordsIn healthy young adults, hexarelin and galanin each raised prolactin to a similar degree.
Peptide
Hexarelin
Outcome
IncreasePRL secretion after hexarelin
Study
n = 5
Comparator
Galanin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 micrograms/kg · intravenousAs given in this study (human).
Measurements
PRL response
507.9 micrograms*min/L
hexarelin
PRL response
743 micrograms*min/L
galanin
Source sentences
Summary
PRL secretion was increased to the same extent by HEX and GAL (507.9 +/- 81.1 and 743.0 +/- 164.7 micrograms*min/L) which showed no interaction (603.5 +/- 75.7 micrograms*min/L).
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
Report a problemFND-0985468303
03HumanNon-randomized trialEfficacy outcome
In normal young volunteers, hexarelin increased ACTH secretion, whereas galanin alone had no effect.
In plain wordsIn healthy young adults, hexarelin raised ACTH, but galanin alone did not.
Peptide
Hexarelin
Outcome
IncreaseACTH secretion after hexarelin
Study
n = 5
Comparator
Galanin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 micrograms/kg · intravenousAs given in this study (human).
Measurements
ACTH response
924.5 pg*min/ml
hexarelin
ACTH response
759.5 pg*min/ml
galanin alone
Source sentences
Summary
HEX elicited an increase in both ACTH and F secretion (924.5 +/- 169.7 pg*min/ml and 6131.3 +/- 616.6 micrograms*min/L) while GAL had no effect when given alone (759.5 +/- 185.5 pg*min/ml and 5350.3 +/- 755.6 micrograms*min/L) and did not modify the effect of HEX (891.3 +/- 159.2 pg*min/ml and 5877.…
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
Report a problemFND-0985468305
04HumanNon-randomized trialEfficacy outcome
In normal young volunteers, hexarelin increased cortisol secretion, whereas galanin alone had no effect.
In plain wordsIn healthy young adults, hexarelin raised cortisol, but galanin alone did not.
Peptide
Hexarelin
Outcome
IncreaseCortisol secretion after hexarelin
Study
n = 5
Comparator
Galanin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2.0 micrograms/kg · intravenousAs given in this study (human).
Measurements
Cortisol response
6131.3 micrograms*min/L
hexarelin
Cortisol response
5350.3 micrograms*min/L
galanin alone
Source sentences
Summary
HEX elicited an increase in both ACTH and F secretion (924.5 +/- 169.7 pg*min/ml and 6131.3 +/- 616.6 micrograms*min/L) while GAL had no effect when given alone (759.5 +/- 185.5 pg*min/ml and 5350.3 +/- 755.6 micrograms*min/L) and did not modify the effect of HEX (891.3 +/- 159.2 pg*min/ml and 5877.…
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
Report a problemFND-0985468306

Studies that did not test the peptide alone8

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

05HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, cyproheptadine blunted the GH response to hexarelin, but the difference was not significant.
In plain wordsIn healthy young adults, cyproheptadine given first lowered the growth hormone rise caused by hexarelin, but not significantly.
Peptide
Hexarelin
Outcome
No significant changeGH response to hexarelin after cyproheptadine
Study
n = 7
Comparator
Hexarelin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH response
1636.4 micrograms*min/L
hexarelin alone
GH response
1164.8 micrograms*min/L
cyproheptadine plus hexarelin
Source sentences
Summary
In group B, the GH response to HEX (1636.4 +/- 267.5 micrograms*min/L) was blunted by CYPRO (1164.8 +/- 212.3 micrograms*min/L) but this difference did not attained statistical significance.
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468309
06HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, cyproheptadine did not modify the prolactin response to hexarelin.
In plain wordsIn healthy young adults, cyproheptadine given first did not change the prolactin rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changePRL response to hexarelin after cyproheptadine
Study
n = 7
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Measurements
PRL response
599.5 micrograms*min/L
hexarelin alone
PRL response
638.9 micrograms*min/L
cyproheptadine plus hexarelin
Source sentences
Summary
On the other hand, CYPRO did not modify the HEX-induced PRL (599.5 +/- 129.2 vs 638.9 +/- 131.9 micrograms*min/L), ACTH (1282.8 +/- 222.0 vs 1330.2 +/- 347.0 pg*min/ml) and F response (4738.3 +/- 355.3 vs 4580.9 +/- 857.3 micrograms*min/L).
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468310
07HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, cyproheptadine did not modify the ACTH response to hexarelin.
In plain wordsIn healthy young adults, cyproheptadine given first did not change the ACTH rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changeACTH response to hexarelin after cyproheptadine
Study
n = 7
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Measurements
ACTH response
1282.8 pg*min/ml
hexarelin alone
ACTH response
1330.2 pg*min/ml
cyproheptadine plus hexarelin
Source sentences
Summary
On the other hand, CYPRO did not modify the HEX-induced PRL (599.5 +/- 129.2 vs 638.9 +/- 131.9 micrograms*min/L), ACTH (1282.8 +/- 222.0 vs 1330.2 +/- 347.0 pg*min/ml) and F response (4738.3 +/- 355.3 vs 4580.9 +/- 857.3 micrograms*min/L).
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468311
08HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, cyproheptadine did not modify the cortisol response to hexarelin.
In plain wordsIn healthy young adults, cyproheptadine given first did not change the cortisol rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changeCortisol response to hexarelin after cyproheptadine
Study
n = 7
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Measurements
Cortisol response
4738.3 micrograms*min/L
hexarelin alone
Cortisol response
4580.9 micrograms*min/L
cyproheptadine plus hexarelin
Source sentences
Summary
On the other hand, CYPRO did not modify the HEX-induced PRL (599.5 +/- 129.2 vs 638.9 +/- 131.9 micrograms*min/L), ACTH (1282.8 +/- 222.0 vs 1330.2 +/- 347.0 pg*min/ml) and F response (4738.3 +/- 355.3 vs 4580.9 +/- 857.3 micrograms*min/L).
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468312
09HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, galanin co-administration did not modify the GH response to hexarelin.
In plain wordsIn healthy young adults, adding galanin did not change the growth hormone rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changeGH response to hexarelin with galanin co-administration
Study
n = 5
Comparator
Hexarelin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH response
1021.8 micrograms*min/L
hexarelin plus galanin
Source sentences
Summary
In group A, the GH response to HEX (1204.2 +/- 312.9 micrograms*min/L) was higher (p < 0.05) than that to GAL alone (305.6 +/- 35.5 micrograms*min/L) and was not modified by GAL co-administration (1021.8 +/- 249.9 micrograms*min/L).
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468302
10HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, hexarelin and galanin showed no interaction on prolactin secretion.
In plain wordsIn healthy young adults, giving galanin with hexarelin did not change the prolactin response.
Peptide
Hexarelin
Outcome
No significant changePRL response to hexarelin with galanin co-administration
Study
n = 5
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Measurements
PRL response
603.5 micrograms*min/L
hexarelin plus galanin
Source sentences
Summary
PRL secretion was increased to the same extent by HEX and GAL (507.9 +/- 81.1 and 743.0 +/- 164.7 micrograms*min/L) which showed no interaction (603.5 +/- 75.7 micrograms*min/L).
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468304
11HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, galanin did not modify the ACTH response to hexarelin.
In plain wordsIn healthy young adults, adding galanin did not change the ACTH rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changeACTH response to hexarelin with galanin co-administration
Study
n = 5
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Measurements
ACTH response
891.3 pg*min/ml
hexarelin plus galanin
Source sentences
Summary
HEX elicited an increase in both ACTH and F secretion (924.5 +/- 169.7 pg*min/ml and 6131.3 +/- 616.6 micrograms*min/L) while GAL had no effect when given alone (759.5 +/- 185.5 pg*min/ml and 5350.3 +/- 755.6 micrograms*min/L) and did not modify the effect of HEX (891.3 +/- 159.2 pg*min/ml and 5877.…
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468307
12HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal young volunteers, galanin did not modify the cortisol response to hexarelin.
In plain wordsIn healthy young adults, adding galanin did not change the cortisol rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changeCortisol response to hexarelin with galanin co-administration
Study
n = 5
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Measurements
Cortisol response
5877.8 micrograms*min/L
hexarelin plus galanin
Source sentences
Summary
HEX elicited an increase in both ACTH and F secretion (924.5 +/- 169.7 pg*min/ml and 6131.3 +/- 616.6 micrograms*min/L) while GAL had no effect when given alone (759.5 +/- 185.5 pg*min/ml and 5350.3 +/- 755.6 micrograms*min/L) and did not modify the effect of HEX (891.3 +/- 159.2 pg*min/ml and 5877.…
1 context sentence(design, population, supporting numbers)
Summary · context
in 12 normal young volunteers (24-30 yr) the following tests were performed: group A (N = 5), HEX (2.0 micrograms/kg i.v. at 0 min), GAL (15.0 micrograms/kg i.v. from 0 to 60 min) and HEX + GAL; group B (N = 7)
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0985468308

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Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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