Treatment with a gonadotrophin releasing hormone agonist before hysterectomy for leiomyomas: results of a multicentre, randomised controlled trial.

Vercellini P, Crosignani PG, Mangioni C, Imparato E, Ferrari A, De Giorgi O

British journal of obstetrics and gynaecology1 Nov 1998Cited by 28 (Europe PMC)

PMID9853762DOI10.1111/j.1471-0528.1998.tb09967.xPepBankPUB-09853762

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women with fibroids, vaginal hysterectomy indication was more frequent after triptorelin than with immediate surgery.
In plain wordsIn women with fibroids, vaginal surgery was suitable more often after triptorelin than with immediate surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseVaginal hysterectomy indication
Study
n = 123
Comparator
Immediate surgery
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Measurements
Vaginal procedure indication
53%
triptorelin 32/60
Between-group difference
37%
triptorelin versus immediate surgery
Between-group difference 95% CI
26 to 51%
triptorelin versus immediate surgery
Odds ratio
6.06 ratio
triptorelin versus immediate surgery
Odds ratio 95% CI
2.6 to 14.1 ratio
triptorelin versus immediate surgery
Source sentences
Summary
Thus the overall rate of indication for a vaginal procedure in the pre-operative medical treatment arm was 32/60 cases (53%), with a between-group difference of 37% (95% CI, 26% to 51%; chi2(1) = 19.18, P < 0.0001; OR 6.06; 95% CI, 2.60 to 14.10).
4 context sentences(design, population, supporting numbers)
Summary · context
After randomisation, four women withdrew from the study, leaving 60 women in the triptorelin arm and 63 in the immediate surgery arm.
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Report a problemFND-0985376202
02HumanRandomized controlled trialEfficacy outcome
In women with fibroids, preoperative haemoglobin was higher after triptorelin than with immediate surgery.
In plain wordsIn women with fibroids, haemoglobin before surgery was higher after triptorelin than with immediate surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePreoperative haemoglobin
Study
n = 123
Comparator
Immediate surgery
Outcome group
Blood counts and hematopoiesis · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Source sentences
Summary
Pre- and post-operative serum haemoglobin and haematocrit levels were significantly higher in the GnRH agonist than in the immediate surgery arm.
3 context sentences(design, population, supporting numbers)
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Report a problemFND-0985376203
03HumanRandomized controlled trialEfficacy outcome
In women with fibroids, postoperative haemoglobin was higher after triptorelin than with immediate surgery.
In plain wordsIn women with fibroids, haemoglobin after surgery was higher after triptorelin than with immediate surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePostoperative haemoglobin
Study
n = 123
Comparator
Immediate surgery
Outcome group
Blood counts and hematopoiesis · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Source sentences
Summary
Pre- and post-operative serum haemoglobin and haematocrit levels were significantly higher in the GnRH agonist than in the immediate surgery arm.
3 context sentences(design, population, supporting numbers)
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Report a problemFND-0985376204
04HumanRandomized controlled trialEfficacy outcome
In women with fibroids, preoperative haematocrit was higher after triptorelin than with immediate surgery.
In plain wordsIn women with fibroids, haematocrit before surgery was higher after triptorelin than with immediate surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePreoperative haematocrit
Study
n = 123
Comparator
Immediate surgery
Outcome group
Blood counts and hematopoiesis · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Source sentences
Summary
Pre- and post-operative serum haemoglobin and haematocrit levels were significantly higher in the GnRH agonist than in the immediate surgery arm.
3 context sentences(design, population, supporting numbers)
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Report a problemFND-0985376205
05HumanRandomized controlled trialEfficacy outcome
In women with fibroids, postoperative haematocrit was higher after triptorelin than with immediate surgery.
In plain wordsIn women with fibroids, haematocrit after surgery was higher after triptorelin than with immediate surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePostoperative haematocrit
Study
n = 123
Comparator
Immediate surgery
Outcome group
Blood counts and hematopoiesis · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Source sentences
Summary
Pre- and post-operative serum haemoglobin and haematocrit levels were significantly higher in the GnRH agonist than in the immediate surgery arm.
3 context sentences(design, population, supporting numbers)
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Report a problemFND-0985376206
06HumanRandomized controlled trialEfficacy outcome
In women with fibroids, other intraoperative and postoperative variables showed no appreciable difference between triptorelin and immediate surgery.
In plain wordsIn women with fibroids, other surgical outcomes showed no appreciable difference between triptorelin and immediate surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOther intraoperative and postoperative variables
Study
n = 123
Comparator
Immediate surgery
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Source sentences
Summary
No appreciable difference was observed between the groups in the other intra- and post-operative variables, including patients' satisfaction.
4 context sentences(design, population, supporting numbers)
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Summary · context
four women withdrew from the study, leaving 60 women in the triptorelin arm and 63 in the immediate surgery arm
Report a problemFND-0985376207
07HumanRandomized controlled trialEfficacy outcome
In women with fibroids, satisfaction showed no appreciable difference between triptorelin and immediate surgery.
In plain wordsIn women with fibroids, satisfaction showed no appreciable difference between triptorelin and immediate surgery.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePatient satisfaction
Study
n = 123
Comparator
Immediate surgery
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Source sentences
Summary
No appreciable difference was observed between the groups in the other intra- and post-operative variables, including patients' satisfaction.
4 context sentences(design, population, supporting numbers)
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Summary · context
four women withdrew from the study, leaving 60 women in the triptorelin arm and 63 in the immediate surgery arm
Report a problemFND-0985376208
08HumanRandomized controlled trialEfficacy outcome
In women with fibroids, abdominal hysterectomy was no longer indicated in 25/53 after triptorelin as vaginal surgery appeared appropriate.
In plain wordsIn women with fibroids, triptorelin changed the proposed operation from abdominal to vaginal surgery in some patients.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseChange in abdominal hysterectomy indication
Study
n = 53
Comparator
Baseline assessment
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
Dose not stated · 12 weeksAs given in this study (human).
Measurements
Change to vaginal procedure indication
47%
25/53 women after treatment
Source sentences
Summary
Clinical assessment after the 12-week GnRH agonist course showed that abdominal hysterectomy was no longer indicated in 25/53 women (47%) as a vaginal procedure appeared appropriate.
3 context sentences(design, population, supporting numbers)
Summary · context
A multicentre, prospective, randomised, controlled study.
Summary · context
One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.
Summary · context
Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.
Report a problemFND-0985376201

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.