In conscious male rats, the GH response (peak and AUC) to the second hexarelin bolus was significantly lower than to the first.
In plain wordsIn rats, the growth hormone response to a second hexarelin dose two hours later was smaller than to the first dose.
- Peptide
- Hexarelin
- Outcome
- DecreaseGH peak and AUC, second versus first hexarelin injection
- Study
ratn: not reported in source
Conscious male Sprague-Dawley rats- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 25 micrograms/kg · intravenous · three boluses at 2 h intervalsAs given in this study (rat).
Measurements
- Peak GH, first injection
- 301 ng/ml
- 25 micrograms/kg i.v.
- Peak GH, second injection
- 149 ng/ml
- 25 micrograms/kg i.v.
- GH AUC, first injection
- 5585 ng/ml per 30 min
- 25 micrograms/kg i.v.
- GH AUC, second injection
- 3056 ng/ml per 30 min
- 25 micrograms/kg i.v.
Source sentences
For both the peak and AUC results there was a significant (P < 0.05) difference in the GH response noted between the first (peak 301 +/- 37 ng/ml; AUC 5585 +/- 700 ng/ml per 30 min) and second (peak 149 +/- 47 ng/ml; AUC 3056 +/- 908 ng/ml per 30 min) injections of hexarelin, but not between the fir…
2 context sentences(design, population, supporting numbers)
On the day of experimentation, these animals received three 25 micrograms/kg i.v. boluses of hexarelin at 2 h intervals with blood sampling at 5, 10, 15, 30, 60, 90 and 120 min after each dose.
In the current study, we investigated the effects of hexarelin administered as repeated doses at 2 h intervals or as a continuous 6, 30 or 174 h infusion to conscious male rats.