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Study · Non-randomized trial · n = 14 · 1998

4 results

Central precocious puberty: a single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment.

Salerno M, Di Maio S, Gasparini N, Mariano A, Macchia V, Tenore A

Hormone research1 Jan 1998Cited by 15 (Europe PMC)

PMID9838241 (opens in a new tab)DOI10.1159/000023275 (opens in a new tab)PepBankPUB-09838241
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In girls with untreated central precocious puberty, triptorelin produced a higher LH peak than the conventional GnRH test.

    In plain wordsIn girls with untreated precocious puberty, triptorelin produced a higher LH peak than the conventional GnRH test.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseLH peak after first injection
    Study

    n = 14

    Comparator
    Conventional GnRH stimulation test
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    LH peak
    70.3 IU/l
    12 h after triptorelin
    LH peak
    31.4 IU/l
    conventional GnRH test

    Source sentences

    Summary
    serum peak values of LH (70.3 +/- 58.5 IU/l), FSH (44.2 +/- 21.7 IU/l) and E2 (489.7 +/- 263.9 pmol/l) were significantly greater than those obtained with the conventional GnRH test (LH 31.4 +/- 21.7, p = 0.002; FSH 19.8 +/- 10.
    2 context sentences
    Summary · context
    The response to the first therapeutic injection of the GnRHa triptorelin was studied in 14 newly diagnosed untreated females with CPP.
    Summary · context
    The results were compared with the response that the same patients had to the conventional GnRH stimulation test performed at the time of diagnosis.
  2. 02HumanNon-randomized trialActivity measurement

    In girls with untreated central precocious puberty, triptorelin produced a higher FSH peak than the conventional GnRH test.

    In plain wordsIn girls with untreated precocious puberty, triptorelin produced a higher FSH peak than the conventional GnRH test.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseFSH peak after first injection
    Study

    n = 14

    Comparator
    Conventional GnRH stimulation test
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    FSH peak
    44.2 IU/l
    12 h after triptorelin
    FSH peak
    19.8 IU/l
    conventional GnRH test

    Source sentences

    Summary
    serum peak values of LH (70.3 +/- 58.5 IU/l), FSH (44.2 +/- 21.7 IU/l) and E2 (489.7 +/- 263.9 pmol/l) were significantly greater than those obtained with the conventional GnRH test (LH 31.4 +/- 21.7, p = 0.002; FSH 19.8 +/- 10.
    3 context sentences
    Summary · context
    7, p = 0.001; E2 83.3 +/- 25, p < 0.001).
    Summary · context
    The response to the first therapeutic injection of the GnRHa triptorelin was studied in 14 newly diagnosed untreated females with CPP.
    Summary · context
    The results were compared with the response that the same patients had to the conventional GnRH stimulation test performed at the time of diagnosis.
  3. 03HumanNon-randomized trialActivity measurement

    In girls with untreated central precocious puberty, triptorelin produced a higher E2 peak than the conventional GnRH test.

    In plain wordsIn girls with untreated precocious puberty, triptorelin produced a higher estradiol peak than the conventional GnRH test.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseE2 peak after first injection
    Study

    n = 14

    Comparator
    Conventional GnRH stimulation test
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    E2 peak
    489.7 pmol/l
    12 h after triptorelin
    E2 peak
    83.3 pmol/l
    conventional GnRH test

    Source sentences

    Summary
    serum peak values of LH (70.3 +/- 58.5 IU/l), FSH (44.2 +/- 21.7 IU/l) and E2 (489.7 +/- 263.9 pmol/l) were significantly greater than those obtained with the conventional GnRH test (LH 31.4 +/- 21.7, p = 0.002; FSH 19.8 +/- 10.
    Summary
    7, p = 0.001; E2 83.3 +/- 25, p < 0.001).
    2 context sentences
    Summary · context
    The response to the first therapeutic injection of the GnRHa triptorelin was studied in 14 newly diagnosed untreated females with CPP.
    Summary · context
    The results were compared with the response that the same patients had to the conventional GnRH stimulation test performed at the time of diagnosis.
  4. 04HumanNon-randomized trialActivity measurement

    In triptorelin-treated girls with pubertal progression, E2 response after the therapeutic injection exceeded the response to the conventional GnRH test.

    In plain wordsIn treated girls with progressing puberty, estradiol response after triptorelin exceeded the response to the conventional GnRH test.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseE2 response with pubertal progression
    Study

    n = 7

    Comparator
    Conventional GnRH stimulation test
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intramuscularAs given in this study (human).

    Measurements

    E2 response
    136.3 pmol/l
    after triptorelin
    E2 response
    73 pmol/l
    after GnRH test

    Source sentences

    Summary
    In 7 girls with evidence of pubertal progression, the E2 response following the GnRHa injection (136.3 +/- 44.4 pmol/l) was significantly higher with respect to the response after the GnRH stimulation test (73.0 +/- 0.0; p < 0.02) indicating an inadequate suppression of the pituitary-gonadal axis.
    2 context sentences
    Summary · context
    Thereafter 22 girls who were already being treated with triptorelin for CPP were evaluated to see whether a single blood sample drawn 12 h after the therapeutic home injection of GnRHa could be informative in assessing adequate suppression of the pituitary-gonadal axis.
    Summary · context
    This response was also compared to the conventional GnRH stimulation test performed 2 days before the therapeutic triptorelin injection.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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