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Study · Randomized controlled trial · n = 48 · 1998

3 results

Gonadotrophin-releasing hormone agonist dose-dependency of pituitary desensitization during controlled ovarian hyperstimulation in IVF.

Janssens RM, Vermeiden JP, Lambalk CB, Schats R, Schoemaker J

Human reproduction (Oxford, England)1 Sept 1998Cited by 11 (Europe PMC)

PMID9806254 (opens in a new tab)DOI10.1093/humrep/13.9.2386 (opens in a new tab)PepBankPUB-09806254
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In IVF patients randomized to daily triptorelin at 5, 15, 50 or 100 microg, no spontaneous LH surges were detected in any dose group.

    In plain wordsIn IVF patients, no spontaneous LH surges were detected at any of four daily triptorelin doses.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Direction not reportedSpontaneous LH surges
    Study

    n = 48

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5, 15, 50 or 100 microg daily · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Spontaneous LH surges were not detected in any of the groups
    2 context sentences
    Summary · context
    A total of 48 IVF patients were divided into four groups of 12 patients.
    Summary · context
    Each group received a different dose of triptorelin acetate, namely 5, 15, 50 or 100 microg s.c. daily.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In IVF patients, pituitary LH response to GnRH appeared dependent on triptorelin dose.

    In plain wordsIn IVF patients, the LH response to GnRH appeared to differ between triptorelin doses.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Direction not reportedPituitary LH response AUC
    Study

    n = 48

    Comparator
    Other triptorelin doses
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5, 15, 50 or 100 microg daily · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    The pituitary LH response to the GnRH test at time of HCG, expressed as area under the curve (AUC), appeared to be dose-dependent.
    5 context sentences
    Summary · context
    A 500 microg GnRH test was performed 90 min before the HCG injection in order to measure the degree of pituitary desensitization.
    Summary · context
    Therefore, a double-blind, prospective and randomized titration study was performed.
    Summary · context
    A total of 48 IVF patients were divided into four groups of 12 patients.
    Summary · context
    Each group received a different dose of triptorelin acetate, namely 5, 15, 50 or 100 microg s.c. daily.
    Summary · context
    Standard ovarian stimulation was carried out using urinary follicle stimulating hormone (FSH) preparations.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In IVF patients receiving triptorelin 5 microg daily, three had ovulated by ovum retrieval.

    In plain wordsIn IVF patients receiving triptorelin 5 microg daily, three had ovulated by egg collection.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Direction not reportedOvulation before ovum retrieval
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5 microg daily · subcutaneousAs given in this study (human).

    Measurements

    Patients who ovulated
    3 patients
    5 microg group, at ovum retrieval

    Source sentences

    Summary
    Spontaneous LH surges were not detected in any of the groups, although three patients in the 5 microg group had ovulated at the time of ovum retrieval.
    4 context sentences
    Summary · context
    Therefore, a double-blind, prospective and randomized titration study was performed.
    Summary · context
    A total of 48 IVF patients were divided into four groups of 12 patients.
    Summary · context
    Each group received a different dose of triptorelin acetate, namely 5, 15, 50 or 100 microg s.c. daily.
    Summary · context
    Standard ovarian stimulation was carried out using urinary follicle stimulating hormone (FSH) preparations.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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