In children with Prader-Willi syndrome, the GH response to hexarelin was significantly lower than that in obese children.
In plain wordsIn children with Prader-Willi syndrome, hexarelin gave a lower growth hormone rise than in obese children.
- Peptide
- Hexarelin
- Outcome
- DecreaseGH response to hexarelin, Prader-Willi syndrome versus obese children
- Study
n = 17
- Comparator
- Obese children
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 2 micrograms/Kg · intravenousAs given in this study (human).
Measurements
- Peak GH
- 7.5 micrograms/l
- hexarelin, PWS
Source sentences
In the PWS children the GH response to Hex (peak = 7.5 +/- 1.6 micrograms/l; AUC = 309 +/- 53) was similar to that observed after GHRH and significantly lower than that observed in the obese children (p < 0.05).
2 context sentences(design, population, supporting numbers)
Seven patients (4 boys and 3 girls, age 2.4-14.2 yr) with PWS, 10 prepubertal obese children (7 boys and 3 girls, age 7.5-12.0 yr), and 24 prepubertal short normal children (11 boys and 13 girls, age 5.9-13 yr) with body weight within +/- 10% of their ideal weight were studied.
All subjects were tested on two occasions with GHRH 1-29 at the dose of 1 microgram/Kg i.v., and with Hex at the dose of 2 micrograms/Kg i.v.